Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride

Mechó-García, María; Blanco-Martínez, Iñaki; Fernandes, Paulo; Macedo-de-Araújo, Rute J.; Faria-Ribeiro, Miguel; González-Méijome, José Manuel

doi:10.3390/photonics10040381

Open AccessArticle

Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride

by

María Mechó-García

^1,2,*

,

Iñaki Blanco-Martínez

^1,2

,

Paulo Fernandes

^1,2

,

Rute J. Macedo-de-Araújo

^1,2

,

Miguel Faria-Ribeiro

^1,2

and

José Manuel González-Méijome

^1,2

¹

Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal

²

Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal

^*

Author to whom correspondence should be addressed.

Photonics 2023, 10(4), 381; https://doi.org/10.3390/photonics10040381

Submission received: 10 March 2023 / Revised: 24 March 2023 / Accepted: 28 March 2023 / Published: 30 March 2023

(This article belongs to the Special Issue Visual Optics)

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Abstract

Pharmacological dilation of the eye to have a larger pupil diameter may allow a better understanding of the wavefront error changes with accommodation. This work aimed to investigate whether dilation of the pupil with Phenylephrine Hydrochloride (PHCl) application changes the accommodative response and the Zernike coefficient magnitude with accommodative demand when computed to a common pupil size. Sixteen right eyes of healthy young subjects were measured with the commercial Hartmann–Shack aberrometer IRX3 (Imagine Eyes, Orsay, France) 30 min after two drops of 1.0% PHCl were applied. The eye wavefronts for accommodative demands from 0 to 5 D were measured in natural conditions and after pupil dilatation. Statistically significant differences between both conditions were found for the Zernike coefficients

C_{3}^{- 1}

,

C_{3}^{1},

C_{4}^{0}

and

C_{6}^{0}

. Without the effect of PHCl, higher values were found for all higher-order Zernike coefficients (HOA). With increased accommodative response, an increase of

C_{3}^{- 1}

and a decrease of

C_{3}^{1}

was observed and the

C_{4}^{0}

becomes more negative; the change from positive to negative is shown in the accommodative demand of 1.5 D. Conversely,

C_{6}^{0}

increases with increasing accommodative demand. To conclude, the results demonstrated that the mydriatic effect of PHCl causes changes in the magnitude of HOA when accommodation is stimulated. The trends observed in the different Zernike coefficients were the same reported in previous studies.

Keywords: accommodation; mydriatics; phenylephrine; wavefront aberrations; Zernike coefficients

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MDPI and ACS Style

Mechó-García, M.; Blanco-Martínez, I.; Fernandes, P.; Macedo-de-Araújo, R.J.; Faria-Ribeiro, M.; González-Méijome, J.M. Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride. Photonics 2023, 10, 381. https://doi.org/10.3390/photonics10040381

AMA Style

Mechó-García M, Blanco-Martínez I, Fernandes P, Macedo-de-Araújo RJ, Faria-Ribeiro M, González-Méijome JM. Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride. Photonics. 2023; 10(4):381. https://doi.org/10.3390/photonics10040381

Chicago/Turabian Style

Mechó-García, María, Iñaki Blanco-Martínez, Paulo Fernandes, Rute J. Macedo-de-Araújo, Miguel Faria-Ribeiro, and José Manuel González-Méijome. 2023. "Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride" Photonics 10, no. 4: 381. https://doi.org/10.3390/photonics10040381

APA Style

Mechó-García, M., Blanco-Martínez, I., Fernandes, P., Macedo-de-Araújo, R. J., Faria-Ribeiro, M., & González-Méijome, J. M. (2023). Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride. Photonics, 10(4), 381. https://doi.org/10.3390/photonics10040381

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Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride

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