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Development, Optimization and Applications of Thin Film Solid Phase Microextraction (TF-SPME) Devices for Thermal Desorption: A Comprehensive Review

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Department of Chemistry and Biochemistry, College of Natural Sciences and Mathematics, The University of Toledo, Toledo, OH 43606, USA
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School of Green Chemistry and Engineering, The University of Toledo, Toledo, OH 43606, USA
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Dr. Nina McClelland Laboratories for Water Chemistry and Environmental Analysis, The University of Toledo, Toledo, OH 43606, USA
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Author to whom correspondence should be addressed.
Separations 2019, 6(3), 39; https://doi.org/10.3390/separations6030039
Received: 5 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 5 August 2019
(This article belongs to the Special Issue Development of Alternative Green Sample Preparation Techniques)
Through the development of solid phase microextraction (SPME) technologies, thin film solid phase microextraction (TF-SPME) has been repeatedly validated as a novel sampling device well suited for various applications. These applications, encompassing a wide range of sampling methods such as onsite, in vivo and routine analysis, benefit greatly from the convenience and sensitivity TF-SPME offers. TF-SPME, having both an increased extraction phase volume and surface area to volume ratio compared to conventional microextraction techniques, allows high extraction rates and enhanced capacity, making it a convenient and ideal sampling tool for ultra-trace level analysis. This review provides a comprehensive discussion on the development of TF-SPME and the applications it has provided thus far. Emphasis is given on its application to thermal desorption, with method development and optimization for this desorption method discussed in detail. Moreover, a detailed outlook on the current progress of TF-SPME development and its future is also discussed with emphasis on its applications to environmental, food and fragrance analysis. View Full-Text
Keywords: TF-SPME; microextraction; thermal desorption; environmental analysis; flavor and fragrance; onsite sampling; in vivo analysis; ultra-trace analysis TF-SPME; microextraction; thermal desorption; environmental analysis; flavor and fragrance; onsite sampling; in vivo analysis; ultra-trace analysis
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Emmons, R.V.; Tajali, R.; Gionfriddo, E. Development, Optimization and Applications of Thin Film Solid Phase Microextraction (TF-SPME) Devices for Thermal Desorption: A Comprehensive Review. Separations 2019, 6, 39.

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