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Numerical Simulation of Fluid Dynamics in a Monolithic Column

Department of Mechanical Science and Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya-shi, Aichi 464-8603, Japan
Author to whom correspondence should be addressed.
Academic Editor: Zuzana Zajickova
Separations 2017, 4(1), 3;
Received: 19 October 2016 / Revised: 26 December 2016 / Accepted: 3 January 2017 / Published: 11 January 2017
(This article belongs to the Special Issue Monolithic Columns in Separation Sciences)
PDF [5323 KB, uploaded 11 January 2017]


As for the measurement of polycyclic aromatic hydrocarbons (PAHs), ultra-performance liquid chromatography (UPLC) is used for PAH identification and densitometry. However, when a solvent containing a substance to be identified passes through a column of UPLC, a dedicated high-pressure-proof device is required. Recently, a liquid chromatography instrument using a monolithic column technology has been proposed to reduce the pressure of UPLC. The present study tested five types of monolithic columns produced in experiments. To simulate the flow field, the lattice Boltzmann method (LBM) was used. The velocity profile was discussed to decrease the pressure drop in the ultra-performance liquid chromatography (UPLC) system. View Full-Text
Keywords: monolithic column; liquid chromatography; PAH; porous structure monolithic column; liquid chromatography; PAH; porous structure

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Yamamoto, K.; Tajima, Y. Numerical Simulation of Fluid Dynamics in a Monolithic Column. Separations 2017, 4, 3.

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