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GERMS
Volume 11
Issue 2
10.18683/germs.2021.1263
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Review

Periodontal Disease in Seropositive Rheumatoid Arthritis: Scoping Review of the Epidemiological Evidence

by
Nik-Madihah Nik-Azis
1,
Nurulhuda Mohd
1,*,
Badiah Baharin
1,
Mohd Shahrir Mohamed Said
2,
Fazalina Mohd Fadzilah
3 and
Nor Hazla Mohamed Haflah
4
1
Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
2
Rheumatology Unit, Medical Department, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia
3
Radiology Department, Sunway Medical Centre, Bandar Sunway, Petaling Jaya 47500, Selangor, Malaysia
4
Orthopaedic Department, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia
*
Author to whom correspondence should be addressed.
GERMS 2021, 11(2), 266-286; https://doi.org/10.18683/germs.2021.1263
Submission received: 28 September 2020 / Revised: 13 April 2021 / Accepted: 25 April 2021 / Published: 2 June 2021
Versions Notes

Abstract

The link between periodontal disease (PD) and rheumatoid arthritis (RA) has been hypothesized to lie in the anti-cyclic citrullinated protein antibody (ACPA) molecules present in seropositive RA. This review aimed to discuss how RA and specifically ACPA-positive RA link to PD, and appraise the epidemiological evidence on the relationship between ACPA-positive RA and PD. Articles were searched following the PRISMA guideline across the MEDLINE, Web of Science, Scopus and Cochrane Library databases. A total of 21 articles met the inclusion criteria of reporting the epidemiological data on the different ACPA status of the subjects with RA and PD (or periodontitis) parameters. A discrepancy is noted in the epidemiological evidence on the difference in the prevalence and severity of PD between ACPA-positive and ACPA-negative RA patients. Although the link between RA and PD is mostly discussed in terms of ACPA, reports on the different manifestations of PD between the two RA subsets remains inconclusive.
Keywords: Anti-Citrullinated Protein Antibodies; Periodontal Disease; Periodontitis; Rheumatoid Arthritis; Rheumatoid Factor Anti-Citrullinated Protein Antibodies; Periodontal Disease; Periodontitis; Rheumatoid Arthritis; Rheumatoid Factor

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MDPI and ACS Style

Nik-Azis, N.-M.; Mohd, N.; Baharin, B.; Said, M.S.M.; Fadzilah, F.M.; Haflah, N.H.M. Periodontal Disease in Seropositive Rheumatoid Arthritis: Scoping Review of the Epidemiological Evidence. GERMS 2021, 11, 266-286. https://doi.org/10.18683/germs.2021.1263

AMA Style

Nik-Azis N-M, Mohd N, Baharin B, Said MSM, Fadzilah FM, Haflah NHM. Periodontal Disease in Seropositive Rheumatoid Arthritis: Scoping Review of the Epidemiological Evidence. GERMS. 2021; 11(2):266-286. https://doi.org/10.18683/germs.2021.1263

Chicago/Turabian Style

Nik-Azis, Nik-Madihah, Nurulhuda Mohd, Badiah Baharin, Mohd Shahrir Mohamed Said, Fazalina Mohd Fadzilah, and Nor Hazla Mohamed Haflah. 2021. "Periodontal Disease in Seropositive Rheumatoid Arthritis: Scoping Review of the Epidemiological Evidence" GERMS 11, no. 2: 266-286. https://doi.org/10.18683/germs.2021.1263

APA Style

Nik-Azis, N.-M., Mohd, N., Baharin, B., Said, M. S. M., Fadzilah, F. M., & Haflah, N. H. M. (2021). Periodontal Disease in Seropositive Rheumatoid Arthritis: Scoping Review of the Epidemiological Evidence. GERMS, 11(2), 266-286. https://doi.org/10.18683/germs.2021.1263

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