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Open AccessArticle

Generic Model Control Applied to E. coli BL21(DE3) Fed-Batch Cultures

1
CNRS, CentraleSupélec, Laboratoire des Signaux et Systèmes, Université Paris-Saclay, 3 Rue Joliot-Curie, 91192 Gif sur Yvette, France
2
Systems, Estimation, Control and Optimization (SECO), University of Mons, 31, Boulevard Dolez, 7000 Mons, Belgium
*
Authors to whom correspondence should be addressed.
Processes 2020, 8(7), 772; https://doi.org/10.3390/pr8070772 (registering DOI)
Received: 13 May 2020 / Revised: 23 June 2020 / Accepted: 28 June 2020 / Published: 1 July 2020
(This article belongs to the Special Issue Redesign Processes in the Age of the Fourth Industrial Revolution)
This work proposes a Generic Model Control (GMC) strategy to regulate biomass growth in fed-batch cultures of Escherichia coli BL21(DE3). The control law is established using a previously validated mechanistic model based on the overflow metabolism paradigm. A model reduction is carried out to prevent the controller from relying on kinetics, which may be uncertain. In order to limit the controller to the use of a single measurement, i.e., biomass concentration which is readily available, a Kalman filter is designed to reconstruct the nonmeasurable information from the outlet gas and the remaining stoichiometry. Several numerical simulations are presented to assess the controller robustness with respect to model uncertainty. Experimental validation of the proposed GMC strategy is achieved with a lab-scale bioreactor. View Full-Text
Keywords: bioprocess control; generic model control; linearizing control; biotechnology bioprocess control; generic model control; linearizing control; biotechnology
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Abadli, M.; Dewasme, L.; Tebbani, S.; Dumur, D.; Vande Wouwer, A. Generic Model Control Applied to E. coli BL21(DE3) Fed-Batch Cultures. Processes 2020, 8, 772.

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