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Cell Factories for Industrial Production Processes: Current Issues and Emerging Solutions

Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 2800 Kgs. Lyngby, Denmark
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Processes 2020, 8(7), 768; https://doi.org/10.3390/pr8070768
Received: 30 March 2020 / Revised: 19 June 2020 / Accepted: 22 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Bioreactor System: Design, Modeling and Continuous Production Process)
Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively. View Full-Text
Keywords: cell factory; lignocellulosic biomass; biomass pretreatment; lignocellulosic inhibitors; Yarrowia lipolytica; Trichosporon oleaginosus; Ustilago cynodontis; Debaryomyces hansenii; bioreactor configuration cell factory; lignocellulosic biomass; biomass pretreatment; lignocellulosic inhibitors; Yarrowia lipolytica; Trichosporon oleaginosus; Ustilago cynodontis; Debaryomyces hansenii; bioreactor configuration
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Navarrete, C.; Jacobsen, I.H.; Martínez, J.L.; Procentese, A. Cell Factories for Industrial Production Processes: Current Issues and Emerging Solutions. Processes 2020, 8, 768.

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