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Open AccessFeature PaperReview

Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

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Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA
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Composite and Nanocomposite Advanced Manufacturing Centre–Biomaterials, Rapid City, SD 57701, USA
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BuG ReMeDEE Consortium, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA
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Faculty of Science, Universiti Teknologi Malaysia, Johor 81310, Malaysia
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Author to whom correspondence should be addressed.
Processes 2020, 8(7), 747; https://doi.org/10.3390/pr8070747
Received: 27 May 2020 / Revised: 20 June 2020 / Accepted: 20 June 2020 / Published: 27 June 2020
(This article belongs to the Special Issue Study of Biodegradation and Bioremediation)
The global burden of cancer is on the rise, and as a result, the number of therapeutics administered for chemotherapy is increasing. The occupational exposure, recalcitrant nature and ecotoxicological toxicity of these therapeutics, referred to as antineoplastic (ANP) drugs, have raised concerns about their safe remediation. This review provides an overview of the environmental source of ANPs agents, with emphasis on the currently used remediation approaches. Outpatient excreta, hospital effluents, and waste from pharmaceutical industries are the primary source of ANP waste. The current review describes various biotic and abiotic methods used in the remediation of ANP drugs in the environment. Abiotic methods often generate transformation products (TPs) of unknown toxicity. In this light, obtaining data on the environmental toxicity of ANPs and its TPs is crucial to determine their toxic effect on the ecosystem. We also discuss the biodegradation of ANP drugs using monoculture of fungal and bacterial species, and microbial consortia in sewage treatment plants. The current review effort further explores a safe and sustainable approach for ANP waste treatment to replace existing chemical and oxidation intensive treatment approaches. To conclude, we assess the possibility of integrating biotic and abiotic methods of ANP drug degradation. View Full-Text
Keywords: antineoplastic drug; environment; toxicity; remediation; biodegradation antineoplastic drug; environment; toxicity; remediation; biodegradation
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MDPI and ACS Style

Tripathi, A.K.; David, A.; Govil, T.; Rauniyar, S.; Rathinam, N.K.; Goh, K.M.; Sani, R.K. Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions. Processes 2020, 8, 747.

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