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Open AccessArticle

Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines

1
Departamento de Química Analítica y Alimentaria, Universidade de Vigo, Circunvalación ao Campus Universitario, 36310 Vigo, Pontevedra, Spain
2
Centro Regional de Estudios en Alimentos Saludables, Av. Universidad 330, Curauma-Placilla, Valparaíso 2373223, Chile
3
Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Av. Brasil 2085, Valparaíso 2362803, Chile
4
International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
5
Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña 1093, Valparaíso 2360102, Chile
*
Author to whom correspondence should be addressed.
Processes 2020, 8(6), 715; https://doi.org/10.3390/pr8060715
Received: 23 May 2020 / Revised: 15 June 2020 / Accepted: 16 June 2020 / Published: 20 June 2020
(This article belongs to the Special Issue Sustainable Food Processing Processes)
Globe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells. View Full-Text
Keywords: artichoke discards; polyphenols; antioxidant activity; inulin; Caco-2; MCF-7 artichoke discards; polyphenols; antioxidant activity; inulin; Caco-2; MCF-7
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Noriega-Rodríguez, D.; Soto-Maldonado, C.; Torres-Alarcón, C.; Pastrana-Castro, L.; Weinstein-Oppenheimer, C.; Zúñiga-Hansen, M.E. Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines. Processes 2020, 8, 715.

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