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Processes 2018, 6(10), 177;

Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs

Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Schaper & Brümmer GmbH & Co. KG, 38259 Salzgitter, Germany
Julius-Kühn-Institut, Bundesforschungsinstitut für Kulturpflanzen, 14195 Berlin, Germany
Boehringer Ingelheim Pharma GmbH & Co. KG, 55216 Ingelheim am Rhein, Germany
Author to whom correspondence should be addressed.
Received: 24 August 2018 / Revised: 21 September 2018 / Accepted: 23 September 2018 / Published: 1 October 2018
(This article belongs to the Special Issue Process Design, Integration, and Intensification)
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The production of plant-based extracts is significantly influenced by traditional techniques and the natural variability of feedstock. For that reason, the discussion of innovative approaches to improve the manufacturing of established products and the development of new products within the regulatory framework is essential to adapt to shifting quality standards. This perspective of members of the DECHEMA/ProcessNet working group on plant-based extracts outlines extraction business models and the regulatory framework regarding the extraction of traditional herbal medicines as complex extracts. Consequently, modern approaches to innovative process design methods like QbD (Quality by Design) and quality control in the form of PAT (Process Analytical Technology) are necessary. Further, the benefit of standardized laboratory equipment combined with physico-chemical predictive process modelling and innovative modular, flexible batch or continuous manufacturing technologies which are fully automated by advanced process control methods are described. A significant reduction of the cost of goods, i.e., by a factor of 4–10, and decreased investments of about 1–5 mil. € show the potential for new products which are in line with market requirements. View Full-Text
Keywords: natural products; phytomedicines; extraction; manufacturing; regulatory natural products; phytomedicines; extraction; manufacturing; regulatory

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Uhlenbrock, L.; Sixt, M.; Tegtmeier, M.; Schulz, H.; Hagels, H.; Ditz, R.; Strube, J. Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs. Processes 2018, 6, 177.

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