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Article

The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level

by
Sadaf Jamal Gilani
1,
May Nasser Bin-Jumah
2,3,4,
Fahad A. Al-Abbasi
5,
Fatima M. Albohairy
6,
Muhammad Shahid Nadeem
5,
Mohammed Muqtader Ahmed
7,
Sami I. Alzarea
8 and
Imran Kazmi
5,*
1
Department of Basic Health Sciences, Preparatory Year, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2
Biology Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
3
Environment and Biomaterial Unit, Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
4
Saudi Society for Applied Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
5
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
6
Electron Microscope Research Unit, Health Sciences Research Center, Princes Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
7
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
8
Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia
*
Author to whom correspondence should be addressed.
Processes 2022, 10(7), 1396; https://doi.org/10.3390/pr10071396
Submission received: 7 June 2022 / Revised: 3 July 2022 / Accepted: 13 July 2022 / Published: 18 July 2022
(This article belongs to the Special Issue Natural Products for Drug Discovery and Development)
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Abstract

Hibiscetin, as one of the main bioactive constituents of Hibiscus sabdariffa, has many pharmacological activities, but its antihyperglycemic activity has not been fully interpreted yet. The current research was developed from this perspective. The study intended to appraise the antidiabetic capability of hibiscetin in a high-fat diet (HFD) and streptozotocin (STZ; 50 mg/kg, intraperitoneally)-induced diabetes in an experimental animal. The efficiency of hibiscetin at 10 mg/kg in an “HFD/STZ model” remedy in rats with experimentally caused diabetes was explored for 42 days. The efficacy of hibiscetin was observed on several diabetes parameters. The average body weight and an array of biochemical markers were determined, including blood glucose, insulin, total protein (TP), lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), IL-6, IL-1β, tumor necrosis factor-α (TNF-α), adiponectin, leptin, resistin, malondialdehyde (MDA), catalase (CAT), glutathione (GSH), and superoxide dismutase (SOD). The antidiabetic benefits of hibiscetin were proven by a substantial reduction in blood glucose, lipid profile (TC and TG), total protein, IL-6, IL-1β, MDA, TNF-α, leptin, adiponectin, ALT, and AST in the therapy group compared to the diabetic disease standard. Furthermore, hibiscetin therapy also reversed the lowered levels of insulin, resistin, GSH, SOD, and CAT in diabetic rats. It was determined that hibiscetin may be beneficial in terms of reducing diabetes problems due to its effects on both oxidative stress and inflammation and that more research for this design should be conducted.
Keywords: hibiscetin; antidiabetic activity; HFD/STZ model; tumor necrosis factor-α; malondialdehyde hibiscetin; antidiabetic activity; HFD/STZ model; tumor necrosis factor-α; malondialdehyde

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MDPI and ACS Style

Gilani, S.J.; Bin-Jumah, M.N.; Al-Abbasi, F.A.; Albohairy, F.M.; Nadeem, M.S.; Ahmed, M.M.; Alzarea, S.I.; Kazmi, I. The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level. Processes 2022, 10, 1396. https://doi.org/10.3390/pr10071396

AMA Style

Gilani SJ, Bin-Jumah MN, Al-Abbasi FA, Albohairy FM, Nadeem MS, Ahmed MM, Alzarea SI, Kazmi I. The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level. Processes. 2022; 10(7):1396. https://doi.org/10.3390/pr10071396

Chicago/Turabian Style

Gilani, Sadaf Jamal, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Fatima M. Albohairy, Muhammad Shahid Nadeem, Mohammed Muqtader Ahmed, Sami I. Alzarea, and Imran Kazmi. 2022. "The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level" Processes 10, no. 7: 1396. https://doi.org/10.3390/pr10071396

APA Style

Gilani, S. J., Bin-Jumah, M. N., Al-Abbasi, F. A., Albohairy, F. M., Nadeem, M. S., Ahmed, M. M., Alzarea, S. I., & Kazmi, I. (2022). The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level. Processes, 10(7), 1396. https://doi.org/10.3390/pr10071396

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