Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn
Abstract
:1. Introduction
2. Defining Donor Sex Exposure
3. Evidence in the Preterm Newborn for Donor Sex Effects on Transfusion Recipient Outcomes
4. How Might Donor Sex Influence Outcome?
4.1. Inherent Differences in RBCs from Male and Female Donors
4.2. Transfusion Related Immunomodulation and the Influence of Donor Sex
4.3. Transfusion Related Endothelial Activation and the Influence of Donor Sex
5. Design Considerations for Future Clinical Studies in the Preterm Newborn
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Crawford, T.M.; Andersen, C.C.; Stark, M.J. Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn. Children 2022, 9, 1980. https://doi.org/10.3390/children9121980
Crawford TM, Andersen CC, Stark MJ. Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn. Children. 2022; 9(12):1980. https://doi.org/10.3390/children9121980
Chicago/Turabian StyleCrawford, Tara M., Chad C. Andersen, and Michael J. Stark. 2022. "Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn" Children 9, no. 12: 1980. https://doi.org/10.3390/children9121980