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Review

The Relationship between COVID-19 and Innate Immunity in Children: A Review

by 1,2,3, 1 and 2,3,4,*,†
1
Istituto di Pediatria, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
2
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
3
Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
4
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
Current address: Danilo Buonsenso, Largo A. Gemelli 8, 00168 Rome, Italy.
Academic Editor: Anna Nilsson
Children 2021, 8(4), 266; https://doi.org/10.3390/children8040266
Received: 21 February 2021 / Revised: 25 March 2021 / Accepted: 26 March 2021 / Published: 30 March 2021
(This article belongs to the Special Issue Childhood Innate Immunity and Infectious Diseases)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the pandemic viral pneumonia that was first identified in Wuhan, China, in December 2019, and has since rapidly spread around the world. The number of COVID-19 cases recorded in pediatric age is around 1% of the total. The immunological mechanisms that lead to a lower susceptibility or severity of pediatric patients are not entirely clear. At the same time, the immune dysregulation found in those children who developed the multisystem inflammatory syndrome (MIC-S) is not yet fully understood. The aim of this review is to analyze the possible influence of children’s innate immune systems, considering the risk of contracting the virus, spreading it, and developing symptomatic disease or complications related to infection. View Full-Text
Keywords: COVID-19; children; coronavirus; innate immunity; SARS-CoV-2; pandemic; MIC-S COVID-19; children; coronavirus; innate immunity; SARS-CoV-2; pandemic; MIC-S
MDPI and ACS Style

Valentini, P.; Sodero, G.; Buonsenso, D. The Relationship between COVID-19 and Innate Immunity in Children: A Review. Children 2021, 8, 266. https://doi.org/10.3390/children8040266

AMA Style

Valentini P, Sodero G, Buonsenso D. The Relationship between COVID-19 and Innate Immunity in Children: A Review. Children. 2021; 8(4):266. https://doi.org/10.3390/children8040266

Chicago/Turabian Style

Valentini, Piero, Giorgio Sodero, and Danilo Buonsenso. 2021. "The Relationship between COVID-19 and Innate Immunity in Children: A Review" Children 8, no. 4: 266. https://doi.org/10.3390/children8040266

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