Next Article in Journal
Vitamin D Status in Children in Greece and Its Relationship with Sunscreen Application
Next Article in Special Issue
Association between CCC-2 and Structural Language, Pragmatics, Social Cognition, and Executive Functions in Children with Developmental Language Disorder
Previous Article in Journal
Hemolytic Uremic Syndrome Due to Methylmalonic Acidemia and Homocystinuria in an Infant: A Case Report and Literature Review
Previous Article in Special Issue
Consistency of a Nonword Repetition Task to Discriminate Children with and without Developmental Language Disorder in Catalan–Spanish and European Portuguese Speaking Children
Open AccessArticle

Gaze Following and Pupil Dilation as Early Diagnostic Markers of Autism in Toddlers

1
Department of Psychology, University of Oviedo, 33003 Oviedo, Spain
2
Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Complutense University of Madrid, 28223 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Eva Aguilar Mediavilla
Children 2021, 8(2), 113; https://doi.org/10.3390/children8020113
Received: 13 December 2020 / Revised: 29 January 2021 / Accepted: 1 February 2021 / Published: 5 February 2021
Background: Children with autism spectrum disorder (ASD) show certain characteristics in visual attention. These may generate differences with non-autistic children in the integration of relevant social information to set the basis of communication. Reliable and objective measurement of these characteristics in a language learning context could contribute to a more accurate early diagnosis of ASD. Gaze following and pupil dilation are being studied as possible reliable measures of visual attention for the early detection of ASD. The eye-tracking methodology allows objective measurement of these biomarkers. The aim of this study is to determine whether measurements of gaze following and pupillary dilation in a linguistic interaction task are potential objective biomarkers for the early diagnosis of ASD. Method: A group of 20 children between 17 and 24 months of age, made up of 10 neurotypical children (NT) and 10 children with an increased likelihood of developing ASD were paired together according to chronological age. A human face on a monitor pronounced pseudowords associated with pseudo-objects. Gaze following and pupil dilation were registered during the task These measurements were captured using eye-tracking methodology. Results: Significant statistical differences were found in the time of gaze fixation on the human face and on the object, as well as in the number of gazes. Children with an increased possibility of developing ASD showed a slightly higher pupil dilation than NT children. However, this difference was not statistically significant. Nevertheless, their pupil dilation was uniform throughout the different periods of the task while NT participants showed greater dilation on hearing the pseudoword. Conclusions: The fixing and the duration of gaze, objectively measured by a Tobii eye-tracking system, could be considered as potential biomarkers for early detection of ASD. Additionally, pupil dilation measurement could reflect differential activation patterns during word processing in possible ASD toddlers and NT toddlers. View Full-Text
Keywords: language acquisition; autism; eye-tracker; pseudowords; pupillometry; gaze fixation language acquisition; autism; eye-tracker; pseudowords; pupillometry; gaze fixation
Show Figures

Figure 1

MDPI and ACS Style

Camero, R.; Martínez, V.; Gallego, C. Gaze Following and Pupil Dilation as Early Diagnostic Markers of Autism in Toddlers. Children 2021, 8, 113. https://doi.org/10.3390/children8020113

AMA Style

Camero R, Martínez V, Gallego C. Gaze Following and Pupil Dilation as Early Diagnostic Markers of Autism in Toddlers. Children. 2021; 8(2):113. https://doi.org/10.3390/children8020113

Chicago/Turabian Style

Camero, Raquel; Martínez, Verónica; Gallego, Carlos. 2021. "Gaze Following and Pupil Dilation as Early Diagnostic Markers of Autism in Toddlers" Children 8, no. 2: 113. https://doi.org/10.3390/children8020113

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop