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Review

Current Insights into Atopic March

1
Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan
2
Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan
3
Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Helen Fisher
Children 2021, 8(11), 1067; https://doi.org/10.3390/children8111067
Received: 31 October 2021 / Revised: 10 November 2021 / Accepted: 16 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Current Research on Pediatric Allergy and Immunodeficiency)
The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as “atopic march”. Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset. View Full-Text
Keywords: atopic march; atopic dermatitis; food allergy; allergic asthma; allergic rhinitis; skin barrier dysfunction; alarmin; group 2 innate lymphoid cells; type 2 inflammation; oxidative stress; specific biomarker; epidemiology; phenotype; early intervention; emollient atopic march; atopic dermatitis; food allergy; allergic asthma; allergic rhinitis; skin barrier dysfunction; alarmin; group 2 innate lymphoid cells; type 2 inflammation; oxidative stress; specific biomarker; epidemiology; phenotype; early intervention; emollient
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MDPI and ACS Style

Tsuge, M.; Ikeda, M.; Matsumoto, N.; Yorifuji, T.; Tsukahara, H. Current Insights into Atopic March. Children 2021, 8, 1067. https://doi.org/10.3390/children8111067

AMA Style

Tsuge M, Ikeda M, Matsumoto N, Yorifuji T, Tsukahara H. Current Insights into Atopic March. Children. 2021; 8(11):1067. https://doi.org/10.3390/children8111067

Chicago/Turabian Style

Tsuge, Mitsuru, Masanori Ikeda, Naomi Matsumoto, Takashi Yorifuji, and Hirokazu Tsukahara. 2021. "Current Insights into Atopic March" Children 8, no. 11: 1067. https://doi.org/10.3390/children8111067

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