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Article

Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children

1
Third Pediatric Discipline, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
2
Third Pediatric Department, Clinical Emergency Hospital for Children, 2-4, Câmpeni Street, 400217 Cluj-Napoca, Romania
3
Evangelisches Amalie Sieveking Krankenhaus, 22359 Hamburg, Germany
4
Nursing Discipline, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Children 2026, 13(4), 521; https://doi.org/10.3390/children13040521
Submission received: 28 February 2026 / Revised: 28 March 2026 / Accepted: 6 April 2026 / Published: 9 April 2026

Abstract

Irritable bowel syndrome (IBS) and mental health disorders represent common and significant health concerns in pediatric populations. Objectives: This study aimed to evaluate psychological and social risk factors associated with IBS in children and to identify correlations with their gastrointestinal symptoms. Materials and Methods: Children aged 4 to 18 years diagnosed with IBS according to Rome IV criteria were eligible for inclusion. Both patients and parents completed a comprehensive questionnaire detailing gastrointestinal symptom characteristics. Additionally, all children underwent psychological assessment. Results: The study included 24 children with IBS, with a mean age of 12.7 ± 3.4 years. Anxiety was present in 54.2% of cases, and depression in 12.5%. Comparing children with IBS and anxiety to those without these, no statistically significant differences emerged regarding the duration and frequency of abdominal pain; however, abdominal pain intensity was significantly higher in children without anxiety (p = 0.04). The duration of IBS symptoms did not significantly differ in children with or without anxiety (p = 0.21). Impaired emotional self-regulation was identified in 54.2% of participants, and 41.6% exhibited vegetative symptoms in response to stress. Furthermore, 70.8% of parents and/or children reported experiencing a negative family event. Conclusions: The findings suggest that psychological characteristics and adverse family events are important risk factors associated with pediatric IBS. These factors should be systematically considered as integral components of clinical assessment and management.

1. Introduction

Irritable bowel syndrome (IBS) is an abdominal pain-related disorder of the gut–brain interaction [1]. The worldwide pooled prevalence in children is 8.8% [2]. IBS is poorly understood, and many factors are under investigation as possible causes, including genetic, infectious, psychological, antibiotic exposure, dysbiosis, allergies, visceral hypersensitivity, and motility disorders [3]. Due to the lack of a definitive etiology or pathophysiology, treatment options are symptom-focused and address certain risk factors. This uncertainty poses challenges for both families and clinicians, often leading parents and patients to question the diagnosis and seek alternative solutions, some of which are supported by limited evidence [4]. Given this complex landscape, it is important to consider associated psychological factors when managing pediatric IBS.
Mental health concerns are prevalent in children, as globally, 10% to 20% of children and adolescents are affected by mental health conditions [5]. The COVID-19 pandemic has both highlighted and worsened this issue [6]. The incidence of anxiety and depression is higher in children with chronic and life-limiting conditions [7]. These psychological disorders are frequently associated with functional gastrointestinal disorders, manifested by abdominal pain in children [8,9,10,11]. Anxiety disorders and IBS share common genetic pathways [12], such as impairment of the hypothalamic–pituitary–adrenal axis [13], serotonin (5-hydroxytryptamine-5-HT) level and signalling abnormalities [14], altered pain perception [15], and structural and functional changes in the brain [16]. It is not known whether psychological traits precede gastrointestinal symptoms or result from chronic, bothersome digestive complaints [17]. Both psychological and gastrointestinal symptoms can significantly impact quality of life, school adaptation, and relationships with family and peers [18]. Anxiety and depression are the most studied psychological risk factors linked to IBS in children [9]. However, other psychological traits or negative events during childhood might also interact with symptoms of IBS or their severity [19]. The study found that childhood emotional abuse and neglect were particularly significant psychological risk factors. Female sex, childhood emotional trauma, and negative events during adulthood were all independently associated with higher IBS prevalence [19]. As research highlights these associations, examining psychological risk factors in pediatric IBS warrants a focused study.
Beyond anxiety and depression, examining broader psychological personal resources is essential when addressing mental health in children with IBS. Factors such as resilience, coping strategies [20], emotional regulation [21], self-efficacy [22], and social support [23,24] may significantly influence how children perceive and manage gastrointestinal symptoms, potentially buffering stress and reducing symptom severity or frequency.
For example, children with stronger adaptive coping skills and higher resilience may better manage stressors that could otherwise worsen IBS symptoms [20,25]. Effective emotional regulation and supportive social environments can also reduce the negative effects of psychological distress on gut functioning [26,27,28,29]. Including psychological personal resources alongside risk factors gives a more complete understanding of the biopsychosocial mechanisms underlying IBS in children [30,31,32]. Reflecting this clinical complexity, the recent ESPGHAN/NASPGHAN guideline for treating IBS in children underscores the role of lifestyle changes, hypnotherapy, and cognitive behavioural therapy—interventions that target psychological aspects—in symptom management [3], further reinforcing the importance of psychological support as an integral part of care. Hypnotherapy has the strongest evidence [33,34,35] and is strongly recommended by the guideline [3]. Percutaneous Electrical Nerve Field Stimulation [36,37], amitriptyline [38,39] or cyproheptadine [40] may be suggested [3]. However, there is still a need for data to support therapeutic options in children with IBS and pediatric abdominal pain disorders in general [41].
The study aimed to assess the frequency of psychological risk factors among children with IBS and to examine how these factors relate to gastrointestinal symptoms. Additionally, possible risk factors such as family history of IBS or psychiatric disorders, low birth weight, and family events were evaluated.

2. Materials and Methods

The study included children aged 4 to 18 years old diagnosed with IBS according to Rome IV criteria. They were recruited between August 2024 and December 2025. The study was prospective, cross-sectional, and observational. Patients and their parents completed a questionnaire. This questionnaire detailed the characteristics of abdominal pain, such as localisation, intensity on a scale from 0 to 10 (numeric rating scale, from “no pain” to “the worst imaginable pain”), duration, and frequency. It also covered occurrences during the day or night, their relation to food, defecation, or stressful events. Additional information included stool pattern and other symptoms: vomiting, dysphagia, nausea, belching, early satiety, bloating, decreased appetite, sensation of incomplete defecation, urgency, involuntary stool loss, and rectal bleeding.
After appropriate medical evaluation and tailored investigations, the diagnosis of IBS was established. Diagnosis of IBS was based on the Rome IV criteria [1]. Patients with previously diagnosed neurological or psychiatric disorders were excluded from the study.
All children underwent psychological evaluation, and a report was prepared by a single psychologist, blinded to the IBS diagnosis. The psychological consultation included a clinical interview and the following assessments: cognitive tests (Raven [42] and Wechsler Intelligence Scale for Children (WISC) [43], Stanford–Binet Intelligence Scale [43]), developmental scales (Denver Developmental Screening Test [44] and Portage Assessment Scale [45]), emotional and personality tests (Achenbach System of Empirically Based Assessment (ASEBA) [46], Child Depression Inventory (CDI) [47], State-Trait Anxiety Inventory for Children (STAIC) [48]), and projective tests (House–Tree–Person, Family Drawing, Kinetic Family Drawing, Draw a Person Test).
Raven’s Coloured Progressive Matrices was used in children up to 6 years of age, and Raven’s Standard Progressive Matrices was used for ages 6 to 18 years as a nonverbal test to assess abstract reasoning and fluid intelligence through pattern completion tasks. WISC was used for children aged 6 to 16 years to evaluate verbal comprehension, working memory, processing speed, and perceptual reasoning. The Stanford–Binet Intelligence Scale was used to evaluate verbal, abstract, and quantitative reasoning, as well as short-term memory, in children under 6 years of age.
Denver and Portage developmental scales were used in children up to 6 years of age. The Denver Developmental Scale was used to assess language, fine motor, gross motor, and personal–social skills. Portage assessment scale was used to assess motor, socialization, language, self-help, and cognitive skills. Children with developmental delays were excluded from the study.
ASEBA evaluates emotional, social, behavioural, and thought problems. The ASEBA CBCL was completed by parents and administered to children aged 6–18 years. ASEBA YSR (self-report) was used in children aged 11–18 years. CDI, a self-report questionnaire, was used for children and adolescents aged 7 to 17 years to measure affective, cognitive, and behavioural signs of depression, like negative self-esteem, ineffectiveness, interpersonal problems, and negative mood. STAIC was used in children aged 8 to 14 years to assess state anxiety (situational anxiety, transient) and trait anxiety (stable anxiety tendencies).
House–Tree–Person, Family Drawing, Kinetic Family Drawing, and Draw a Person Test were used to evaluate anxiety, fear, emotional disturbance, mental disorders, family relationships, family functioning, and attachment representations in children aged 5 to 12 years. Projective techniques were used as qualitative tools within the clinical psychological evaluation. These were not quantitatively scored. Instead, findings were integrated with the clinical interview and behavioural observation.
The child’s emotional self-regulation was assessed during the clinical interview. Emotional regulation difficulties involve challenges in awareness of emotions, impulse control, and acceptance of emotions. In our reports, diagnosis relied on clinical observation and parental reports, especially when children showed intense emotional reactions during the assessment—such as tantrums or crying—that were disproportionate to the situation and difficult to calm, even with adult support. Increased impulsivity was observed: the child acted without thinking, hit, screamed, left abruptly, and struggled to wait or tolerate frustration. Emotional difficulties (e.g., anxiety, emotional dysregulation) were coded dichotomously (present/absent) based on convergence between projective indicators, clinical observation, and parental reports.
Due to the wide age range of participants (4–18 years) and the developmental variability within the sample, psychological assessment was tailored individually using age-appropriate, validated instruments. Consequently, not all participants completed the same tests, and the resulting variables are not directly comparable across the entire cohort. Instrument selection was tailored for each child or adolescent, aligning with age, developmental stage, and clinical traits. This method eliminated redundancies and delivered the most precise and relevant profile for each case. Perinatal risk factors (low birth weight, parents with IBS or mental illness) and family events (conflicts in the family, parents working abroad, moving, illness or death of a family member, etc.) were also included in the analysis.
Before participation, parents signed a consent form, and children provided assent. The study protocol received approval from the Ethics committee of the “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca (AVIZ 139/19 July 2024).
Statistical analysis. Continuous variables were summarized as mean ± standard deviation (SD) when normally distributed and as median [interquartile range (IQR)] when not normally distributed. Categorical variables were expressed as percentages. The Mann–Whitney U test was used for comparisons between groups when data were non-normally distributed or sample sizes were small. Welch’s t-test was applied for normally distributed continuous variables with unequal variances after outlier assessment. Fisher’s exact test was used to compare categorical variables between groups. Effect sizes were calculated using Cohen’s d. A p-value < 0.05 was considered statistically significant. MedCalc version 22.023 was used for the statistical analysis.

3. Results

Twenty-four children diagnosed with IBS were included in the study. Demographic data and family medical history of the patients are summarized in Table 1.
Data regarding symptoms and signs of children with IBS are detailed in Table 2.
At least one adverse family event was reported by 17/24 (70.8%) patients and parents. The patients’ psychological traits and types of family events found in our study are summarized in Table 3.
Children with IBS and anxiety were compared with those without anxiety. The results of this comparison are summarized in Table 4.
The duration of IBS symptoms did not significantly differ between children with anxiety (median = 6 months, IQR = 3–12) and those without anxiety (median = 3.5 months, IQR = 3–8) (Mann–Whitney U = 41, p = 0.24). After removal of extreme outliers, the mean duration was 8.7 ± 6.3 months in the anxiety group and 5.9 ± 3.6 months in the non-anxiety group. The difference was not statistically significant (Welch’s t = 1.30, p = 0.21), although a moderate effect size was observed (Cohen’s d = 0.56).
Abdominal pain intensity was significantly higher in the group without anxiety. Abdominal pain intensity did not differ significantly in those with good emotional self-regulation (median 6 months, IQR 6–8) as opposed to those with impaired emotional self-regulation (median 7 months, IQR = 6–8) (p = 0.63). There was no statistically significant difference in the intensity of abdominal pain in those with conflicts in the family or those without (p = 0.32).
Abdominal pain was present both during the day and night in 11/24 (45.8%) patients, while 13/24 (54.2%) reported abdominal pain only during the day. Patients who had anxiety were 2.26 times (relative risk) more likely to have abdominal pain during the night compared to those without anxiety, and the odds ratio was 4.3, but the results did not reach statistical significance.
Anxiety was associated in 7/9 (77.8%) patients with IBS predominantly manifested with constipation, 5/11 (45.5%) children with IBS predominantly manifested with diarrhea, and 1/4 (25%) patients with a mixed form of IBS. The association of anxiety was strongest with the form of IBS manifested predominantly with constipation, but without statistical significance (p = 0.12).
There was no statistically significant difference between the children with impaired emotional self-regulation and those without this psychological trait regarding the age, duration, or frequency of the abdominal pain (p > 0.05).

4. Discussion

This study assessed psychological characteristics and family adverse events in children with IBS. Most of the patients were girls (70.8%). IBS predominantly manifested with diarrhea was the most frequent subtype, closely followed by the constipation predominant subtype. There were no patients with an unclassified subtype.
Over 70% of patients and/or their parents reported at least one adverse family event during psychological consultations, with some noting multiple events. Almost half of the children in our study came from families with conflicting events, and almost one-third had a family member who died or was ill. Patterns revealed significant family disruptions in recent decades, including parental migration, which sometimes left children behind or led them to move. Around 16% of the children with IBS had at least one parent working abroad. This study strengthens the idea that family stress and instability are highly prevalent in pediatric IBS, even if causality remains debated.
The relation between adverse childhood events like abuse, neglect, or other potentially traumatic events has been reported by several studies, but conclusions are inconsistent, and results are biassed by the quality of the studies or design [49]. Both adverse childhood events and adverse adulthood experiences are associated with a higher risk of IBS in adults [32]. The long-term impact of these events in childhood is supported by studies in adult patients with IBS, which are correlated with a higher risk, particularly in women, and describe a distinct phenotype of IBS [50,51,52].
Fu et al. found anxiety in 21% of the children with IBS, and depression in 14% of them [53]. More than half of the children diagnosed with IBS in our study exhibited anxiety, and 12.5% depression. The most frequent form of anxiety was performance anxiety. When the intensity of abdominal pain (measured on a numerical scale from 0 to 10) was compared in children with and without anxiety, there was a statistically significant difference, with a more intense abdominal pain reported in the group of children without anxiety. This contradicts previous findings in which the severity of abdominal pain in children was correlated with anxiety [25,54,55]. Only Hollier et al. published results in children with IBS; the rest of the studies included other gut–brain interaction disorders as well [25]. However, Hollier et al. use a different numerical scale to evaluate pain intensity, not a numerical 0-to-10 rating scale. Anxiety and depression can alter signalling between the central nervous system and the enteric nervous system. This can lead to increased visceral sensitivity (heightened perception of gut pain) and altered gut motility (constipation or diarrhea patterns). The study found higher abdominal pain intensity in children without anxiety. It might be explained by the fact that children with anxiety may have chronic hypervigilance, leading to earlier reporting of symptoms, adaptation, or altered perception over time. The limited sample size may have influenced our results.
Higher scores for anxiety and depression were correlated with the duration of symptoms in previous studies [56]. We did not find statistically significant differences between children with IBS with or without anxiety regarding the duration of their symptoms. Non-anxious children might report pain only when it becomes more severe. Chronic stress activates the hypothalamic–pituitary–adrenal axis. This leads to elevated cortisol levels, alters gut permeability and inflammation, and affects motility and microbiota composition. This could contribute to a longer symptom duration and persistent IBS symptoms in anxious or depressed children. Somatisation and pain catastrophising mediate the relationship between IBS symptoms and anxiety, and they should be treatment targets [25]. Vegetative manifestations (autonomic symptoms) such as palpitations, dizziness, sweating, or flushing were reported by nearly 42% of our patients in relation to stressful events. Ruška et al. found symptomatic autonomic dysfunction in 61.5% of the children with IBS [57]. Health-related quality of life could be improved by treating somatisation and functional disability in children with IBS [58]. These are important treatment targets in cognitive behavioural therapy and stress regulation.
Emotional instability and less involvement in social activities were correlated with IBS in children [59]. Emotional instability modulates the perception of visceral stimuli, correlating with lower pain thresholds and higher pain scores [59]. Impaired emotional self-regulation was diagnosed in more than half of the children with IBS in this study. Difficulty connecting emotionally with others was found in almost 38% of the patients with IBS. Pandemic-related social disruption has been recognized as a factor with a negative impact on children with gastrointestinal disorders, including IBS [24].
High rates of school absenteeism have been found in children with IBS, both in primary care settings and in hospitalized children with IBS [60]. Anxiety, gastrointestinal symptoms, and somatisation have a negative impact on school performance [59,61,62]. Almost 38% of our patients admitted to having difficulties in adapting to school or kindergarten. Robbertz et al. recently showed a positive correlation between gastrointestinal symptoms and anxiety during the COVID-19 pandemic, with online schooling being associated with worsening of the symptoms [63].
A recent review identified low birth weight and parental IBS or mental illness as risk factors for IBS in children [31]; however, our group did not include children with birth weight under 2500 g, and few reported parental IBS or mental illness.
The study is a prospective one, with data on gastrointestinal symptom characteristics collected uniformly using a questionnaire based on Rome IV criteria. The analysis included only patients diagnosed with IBS and excluded individuals with other gut–brain interaction disorders. Patient selection was based on the specific diagnosis of IBS to enhance the specificity of the findings in this group compared with most previous studies.
The psychological assessment did not rely solely on standardized quantitative methods. Our integrative framework combined quantitative tests and qualitative approaches—clinical observation, projective techniques, and contextual analysis—to produce a comprehensive, nuanced understanding of participants’ psychological functioning. The study has some limitations that must be acknowledged. Patients were recruited from only one centre. The study group was small, and a control group was not included in the analysis. It is a cross-sectional study. Children had a wide age range, and during psychological consultation, different scales were used for cognitive, developmental, personality, and emotional assessment. This heterogeneity limits direct comparability across the full cohort. Further studies on our patients aim to use the same scales to evaluate psychological factors, suitable for different age groups, with a uniform evaluation of specific variables, and to include more patients over a period of 5 to 10 years to ensure statistical significance of the results.
In considering psychosocial factors, a high proportion of participants reported adverse family experiences, including conflict, illness, death, and parental migration. This supports existing but inconsistent evidence linking early life stressors to IBS risk, notably described in adult populations. Rates of anxiety were notably higher than previously reported, while depression prevalence was comparable. However, in contrast to most prior studies, greater abdominal pain intensity was observed in children without anxiety, and no association was found between psychological symptoms and illness duration. A substantial proportion of patients exhibited somatisation, autonomic symptoms, impaired emotional regulation, and social difficulties, which aligns with literature highlighting that psychosocial factors modulate symptom perception and functional impairment, including school difficulties. While established risk factors such as low birth weight and parental IBS were not identified, possibly due to sample limitations, these findings reinforce the biopsychosocial model of pediatric IBS and contribute new insights into the role of family disruption and emotional functioning.

5. Conclusions

Psychological traits and family events are important risk factors for IBS in children and should not be overlooked in clinical management. Specifically, data suggest that adverse experiences—such as the illness or death of a family member and intrafamilial conflicts—are associated with a significant proportion of pediatric IBS cases. These factors can elevate stress levels, negatively influence emotional regulation, and thereby favour the expression of psychological distress through somatic symptoms.
In this regard, family relationships and contextual factors must be integrated into both assessment and therapeutic intervention. An exclusively somatic approach is insufficient; a biopsychosocial perspective is necessary to optimize clinical outcomes and the well-being of children with IBS.

Author Contributions

Conceptualization, D.P., I.M.L.A. and D.F.; methodology, D.P., R.S.P., V.B. and D.F.; validation, D.P., R.S.P., V.B. and D.F.; writing—original draft preparation, D.P. and I.M.L.A.; writing—review and editing, D.F.; supervision, D.F. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, AVIZ 139/19 July 2024.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
IBSirritable bowel syndrome
IQRinterquartile range
SDstandard deviation

References

  1. Hyams, J.S.; Di Lorenzo, C.; Saps, M.; Shulman, R.J.; Staiano, A.; van Tilburg, M. Functional Disorders: Children and Adolescents. Gastroenterology 2016, 150, 1456–1468.e2. [Google Scholar] [CrossRef] [PubMed]
  2. Korterink, J.J.; Diederen, K.; Benninga, M.A.; Tabbers, M.M. Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis. PLoS ONE 2015, 10, e0126982. [Google Scholar] [CrossRef] [PubMed]
  3. Groen, J.; Gordon, M.; Chogle, A.; Benninga, M.; Borlack, R.; Borrelli, O.; Darbari, A.; Dolinsek, J.; Khlevner, J.; Di Lorenzo, C.; et al. ESPGHAN/NASPGHAN Guidelines for Treatment of Irritable Bowel Syndrome and Functional Abdominal Pain-Not Otherwise Specified in Children Aged 4–18 Years. J. Pediatr. Gastroenterol. Nutr. 2025, 81, 442–471. [Google Scholar] [CrossRef]
  4. Pop, D.; Pop, R.S.; Farcău, D. The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review. Nutrients 2023, 15, 4351. [Google Scholar] [CrossRef] [PubMed]
  5. Whiteford, H.A.; Degenhardt, L.; Rehm, J.; Baxter, A.J.; Ferrari, A.J.; Erskine, H.E.; Charlson, F.J.; Norman, R.E.; Flaxman, A.D.; Johns, N.; et al. Global Burden of Disease Attributable to Mental and Substance Use Disorders: Findings from the Global Burden of Disease Study 2010. Lancet 2013, 382, 1575–1586. [Google Scholar] [CrossRef]
  6. GBD 2021 Diseases and Injuries Collaborators. Global Incidence, Prevalence, Years Lived with Disability (YLDs), Disability-Adjusted Life-Years (DALYs), and Healthy Life Expectancy (HALE) for 371 Diseases and Injuries in 204 Countries and Territories and 811 Subnational Locations, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021. Lancet 2024, 403, 2133–2161. [Google Scholar] [CrossRef]
  7. Barker, M.M.; Beresford, B.; Fraser, L.K. Incidence of Anxiety and Depression in Children and Young People with Life-Limiting Conditions. Pediatr. Res. 2023, 93, 2081–2090. [Google Scholar] [CrossRef]
  8. Zia, J.K.; Lenhart, A.; Yang, P.-L.; Heitkemper, M.M.; Baker, J.; Keefer, L.; Saps, M.; Cuff, C.; Hungria, G.; Videlock, E.J.; et al. Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review. Gastroenterology 2022, 163, 995–1023.e3. [Google Scholar] [CrossRef]
  9. Pop, D.; Man, S.C.; Farcău, D. Anxiety and Depression in Children with Irritable Bowel Syndrome-A Narrative Review. Diagnostics 2025, 15, 433. [Google Scholar] [CrossRef]
  10. Chen, Z.; Chen, Q.; Zhou, L. Anxiety and Depression in Pediatric Patients with Disorder of Brain-Gut Interaction: The Role of Diarrhea and Abdominal Pain as Key Determinants. Front. Pediatr. 2025, 13, 1628222. [Google Scholar] [CrossRef]
  11. Milea, A.C.M.; Casano, C.J.; Sánchez, M.R.; Garcia, J.L. Anxiety, Depressive Symptomatology, and Perfectionism Traits and Their Relationship with Disorders of Gut-Brain Interaction in Children. Pediatr. Gastroenterol. Hepatol. Nutr. 2025, 28, 185–198. [Google Scholar] [CrossRef]
  12. Eijsbouts, C.; Zheng, T.; Kennedy, N.A.; Bonfiglio, F.; Anderson, C.A.; Moutsianas, L.; Holliday, J.; Shi, J.; Shringarpure, S.; 23andMe Research Team; et al. Genome-Wide Analysis of 53,400 People with Irritable Bowel Syndrome Highlights Shared Genetic Pathways with Mood and Anxiety Disorders. Nat. Genet. 2021, 53, 1543–1552. [Google Scholar] [CrossRef] [PubMed]
  13. Gulewitsch, M.D.; Weimer, K.; Enck, P.; Schwille-Kiuntke, J.; Hautzinger, M.; Schlarb, A.A. Stress Reactivity in Childhood Functional Abdominal Pain or Irritable Bowel Syndrome. Eur. J. Pain. 2017, 21, 166–177. [Google Scholar] [CrossRef] [PubMed]
  14. Crowell, M.D. Role of Serotonin in the Pathophysiology of the Irritable Bowel Syndrome. Br. J. Pharmacol. 2004, 141, 1285–1293. [Google Scholar] [CrossRef] [PubMed]
  15. Dorn, S.D.; Palsson, O.S.; Thiwan, S.I.M.; Kanazawa, M.; Clark, W.C.; van Tilburg, M.A.L.; Drossman, D.A.; Scarlett, Y.; Levy, R.L.; Ringel, Y.; et al. Increased Colonic Pain Sensitivity in Irritable Bowel Syndrome Is the Result of an Increased Tendency to Report Pain Rather than Increased Neurosensory Sensitivity. Gut 2007, 56, 1202–1209. [Google Scholar] [CrossRef]
  16. Fadgyas-Stanculete, M.; Buga, A.-M.; Popa-Wagner, A.; Dumitrascu, D.L. The Relationship between Irritable Bowel Syndrome and Psychiatric Disorders: From Molecular Changes to Clinical Manifestations. J. Mol. Psychiatry 2014, 2, 4. [Google Scholar] [CrossRef]
  17. Kumar, A.; Vallabhaneni, P. Anxiety Disorders Presenting as Gastrointestinal Symptoms in Children—A Scoping Review. Clin. Exp. Pediatr. 2025, 68, 344–351. [Google Scholar] [CrossRef]
  18. Sjölund, J.; Kull, I.; Bergström, A.; Ljótsson, B.; Törnblom, H.; Olén, O.; Simrén, M. Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome From Adolescence to Adulthood. Clin. Gastroenterol. Hepatol. 2024, 22, 858–866.e6. [Google Scholar] [CrossRef]
  19. Dong, Z.; Wang, X.; Xuan, L.; Wang, J.; Zhan, T.; Chen, Y.; Xu, S.; Ji, D. The Interaction Effect between Childhood Trauma and Negative Events during Adulthood on Development and Severity of Irritable Bowel Syndrome. BMC Gastroenterol. 2025, 25, 321. [Google Scholar] [CrossRef]
  20. Gamwell, K.L.; Peugh, J.L.; Santucci, N.; Graham, K.; Hommel, K.A. Self-Management and Treatment Adherence in Pediatric Irritable Bowel Syndrome (IBS): A Longitudinal Study. J. Psychosom. Res. 2025, 198, 112396. [Google Scholar] [CrossRef]
  21. Sibelli, A.; Chalder, T.; Everitt, H.; Chilcot, J.; Moss-Morris, R. Positive and Negative Affect Mediate the Bidirectional Relationship between Emotional Processing and Symptom Severity and Impact in Irritable Bowel Syndrome. J. Psychosom. Res. 2018, 105, 1–13. [Google Scholar] [CrossRef] [PubMed]
  22. Lackner, J.M.; Jaccard, J. Specific and Common Mediators of Gastrointestinal Symptom Improvement in Patients Undergoing Education/Support vs. Cognitive Behavioral Therapy for Irritable Bowel Syndrome. J. Consult. Clin. Psychol. 2021, 89, 435–453. [Google Scholar] [CrossRef] [PubMed]
  23. Donovan, E.; Martin, S.R.; Lung, K.; Evans, S.; Seidman, L.C.; Cousineau, T.M.; Cook, E.; Zeltzer, L.K. Pediatric Irritable Bowel Syndrome: Perspectives on Pain and Adolescent Social Functioning. Pain. Med. 2019, 20, 213–222. [Google Scholar] [CrossRef] [PubMed]
  24. Robbertz, A.S.; Cohen, L.L.; Armistead, L.P.; Reed, B. Pandemic-Related Social Disruption and Well-Being in Pediatric Gastrointestinal Diseases. J. Pediatr. Psychol. 2022, 47, 981–990. [Google Scholar] [CrossRef]
  25. Hollier, J.M.; van Tilburg, M.A.L.; Liu, Y.; Czyzewski, D.I.; Self, M.M.; Weidler, E.M.; Heitkemper, M.; Shulman, R.J. Multiple Psychological Factors Predict Abdominal Pain Severity in Children with Irritable Bowel Syndrome. Neurogastroenterol. Motil. 2019, 31, e13509. [Google Scholar] [CrossRef]
  26. Schaper, S.J.; Stengel, A. Emotional Stress Responsivity of Patients with IBS—A Systematic Review. J. Psychosom. Res. 2022, 153, 110694. [Google Scholar] [CrossRef]
  27. Ford, A.C.; Sperber, A.D.; Corsetti, M.; Camilleri, M. Irritable Bowel Syndrome. Lancet 2020, 396, 1675–1688. [Google Scholar] [CrossRef]
  28. Zhang, H.; Wang, Z.; Wang, G.; Song, X.; Qian, Y.; Liao, Z.; Sui, L.; Ai, L.; Xia, Y. Understanding the Connection between Gut Homeostasis and Psychological Stress. J. Nutr. 2023, 153, 924–939. [Google Scholar] [CrossRef]
  29. Diao, Z.; Xu, W.; Guo, D.; Zhang, J.; Zhang, R.; Liu, F.; Hu, Y.; Ma, Y. Causal Association between Psycho-Psychological Factors, Such as Stress, Anxiety, Depression, and Irritable Bowel Syndrome: Mendelian Randomization. Medicine 2023, 102, e34802. [Google Scholar] [CrossRef]
  30. Xing, Z.; Hou, X.; Zhou, K.; Qin, D.; Pan, W. Impact of Parental-Rearing Styles on Irritable Bowel Syndrome in Adolescents: A School-Based Study. J. Gastroenterol. Hepatol. 2014, 29, 463–468. [Google Scholar] [CrossRef]
  31. Low, E.X.S.; Mandhari, M.N.K.A.; Herndon, C.C.; Loo, E.X.L.; Tham, E.H.; Siah, K.T.H. Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review. J. Neurogastroenterol. Motil. 2020, 26, 437–446. [Google Scholar] [CrossRef]
  32. Zhou, Y.; Liu, S.; Xie, S.; Zhang, Q.; Zhang, S.; Zhu, S.; Wu, S. Long-Term Risk of Irritable Bowel Syndrome Associated with Adverse Childhood and Adulthood Experiences: A Large-Scale Prospective Cohort Study. Transl. Psychiatry 2026, 16, 70. [Google Scholar] [CrossRef] [PubMed]
  33. Rutten, J.M.T.M.; Vlieger, A.M.; Frankenhuis, C.; George, E.K.; Groeneweg, M.; Norbruis, O.F.; Tjon A Ten, W.; van Wering, H.M.; Dijkgraaf, M.G.W.; Merkus, M.P.; et al. Home-Based Hypnotherapy Self-Exercises vs Individual Hypnotherapy With a Therapist for Treatment of Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, or Functional Abdominal Pain Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2017, 171, 470–477. [Google Scholar] [CrossRef] [PubMed]
  34. Gulewitsch, M.D.; Schlarb, A.A. Comparison of Gut-Directed Hypnotherapy and Unspecific Hypnotherapy as Self-Help Format in Children and Adolescents with Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Pilot Study. Eur. J. Gastroenterol. Hepatol. 2017, 29, 1351–1360. [Google Scholar] [CrossRef] [PubMed]
  35. Vlieger, A.M.; Menko-Frankenhuis, C.; Wolfkamp, S.C.S.; Tromp, E.; Benninga, M.A. Hypnotherapy for Children with Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Controlled Trial. Gastroenterology 2007, 133, 1430–1436. [Google Scholar] [CrossRef]
  36. Kovacic, K.; Hainsworth, K.; Sood, M.; Chelimsky, G.; Unteutsch, R.; Nugent, M.; Simpson, P.; Miranda, A. Neurostimulation for Abdominal Pain-Related Functional Gastrointestinal Disorders in Adolescents: A Randomised, Double-Blind, Sham-Controlled Trial. Lancet Gastroenterol. Hepatol. 2017, 2, 727–737. [Google Scholar] [CrossRef]
  37. Krasaelap, A.; Sood, M.R.; Li, B.U.K.; Unteutsch, R.; Yan, K.; Nugent, M.; Simpson, P.; Kovacic, K. Efficacy of Auricular Neurostimulation in Adolescents With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial. Clin. Gastroenterol. Hepatol. 2020, 18, 1987–1994.e2. [Google Scholar] [CrossRef]
  38. Bahar, R.J.; Collins, B.S.; Steinmetz, B.; Ament, M.E. Double-Blind Placebo-Controlled Trial of Amitriptyline for the Treatment of Irritable Bowel Syndrome in Adolescents. J. Pediatr. 2008, 152, 685–689. [Google Scholar] [CrossRef]
  39. Saps, M.; Youssef, N.; Miranda, A.; Nurko, S.; Hyman, P.; Cocjin, J.; Di Lorenzo, C. Multicenter, Randomized, Placebo-Controlled Trial of Amitriptyline in Children with Functional Gastrointestinal Disorders. Gastroenterology 2009, 137, 1261–1269. [Google Scholar] [CrossRef]
  40. Sadeghian, M.; Farahmand, F.; Fallahi, G.H.; Abbasi, A. Cyproheptadine for the Treatment of Functional Abdominal Pain in Childhood: A Double-Blinded Randomized Placebo-Controlled Trial. Minerva Pediatr. 2008, 60, 1367–1374. [Google Scholar]
  41. Chakraborty, P.S.; Daniel, R.; Navarro, F.A. Non-Pharmacologic Approaches to Treatment of Pediatric Functional Abdominal Pain Disorders. Front. Pediatr. 2023, 11, 1118874. [Google Scholar] [CrossRef] [PubMed]
  42. Matzen, L.E.; Benz, Z.O.; Dixon, K.R.; Posey, J.; Kroger, J.K.; Speed, A.E. Recreating Raven’s: Software for Systematically Generating Large Numbers of Raven-like Matrix Problems with Normed Properties. Behav. Res. Methods 2010, 42, 525–541. [Google Scholar] [CrossRef] [PubMed]
  43. Siegel, M.; McGuire, K.; Veenstra-VanderWeele, J.; Stratigos, K.; King, B.; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI); Bellonci, C.; Hayek, M.; Keable, H.; Rockhill, C.; et al. Practice Parameter for the Assessment and Treatment of Psychiatric Disorders in Children and Adolescents With Intellectual Disability (Intellectual Developmental Disorder). J. Am. Acad. Child. Adolesc. Psychiatry 2020, 59, 468–496. [Google Scholar] [CrossRef] [PubMed]
  44. Frankenburg, W.K.; Dodds, J.; Archer, P.; Shapiro, H.; Bresnick, B. The Denver II: A Major Revision and Restandardization of the Denver Developmental Screening Test. Pediatrics 1992, 89, 91–97. [Google Scholar] [CrossRef]
  45. Cameron, R.J. Early Intervention for Young Children with Developmental Delay: The Portage Approach. Child. Care Health Dev. 1997, 23, 11–27. [Google Scholar] [CrossRef]
  46. Achenbach, T.M.; Ivanova, M.Y.; Rescorla, L.A. Empirically Based Assessment and Taxonomy of Psychopathology for Ages 1½-90+ Years: Developmental, Multi-Informant, and Multicultural Findings. Compr. Psychiatry 2017, 79, 4–18. [Google Scholar] [CrossRef]
  47. Thapar, A.; Eyre, O.; Patel, V.; Brent, D. Depression in Young People. Lancet 2022, 400, 617–631. [Google Scholar] [CrossRef]
  48. Muris, P.; Merckelbach, H.; Ollendick, T.; King, N.; Bogie, N. Three Traditional and Three New Childhood Anxiety Questionnaires: Their Reliability and Validity in a Normal Adolescent Sample. Behav. Res. Ther. 2002, 40, 753–772. [Google Scholar] [CrossRef]
  49. Joshee, S.; Lim, L.; Wybrecht, A.; Berriesford, R.; Riddle, M. Meta-Analysis and Systematic Review of the Association between Adverse Childhood Events and Irritable Bowel Syndrome. J. Investig. Med. 2022, 70, 1342–1351. [Google Scholar] [CrossRef]
  50. Bureychak, T.; Sjödahl, J.; Barazanji, N.; Orell, G.; Book, O.; Simon, R.; Bednarska, O.; Icenhour, A.; Walter, S. Exploring Associations of Different Types of Childhood Trauma With Symptomatology in Irritable Bowel Syndrome. Neurogastroenterol. Motil. 2025, 37, e70148. [Google Scholar] [CrossRef]
  51. Bradford, K.; Shih, W.; Videlock, E.J.; Presson, A.P.; Naliboff, B.D.; Mayer, E.A.; Chang, L. Association between Early Adverse Life Events and Irritable Bowel Syndrome. Clin. Gastroenterol. Hepatol. 2012, 10, 385–390.e1–3. [Google Scholar] [CrossRef]
  52. Melchior, C.; Wilpart, K.; Midenfjord, I.; Trindade, I.A.; Törnblom, H.; Tack, J.F.; Simrén, M.; Van Oudenhove, L. Relationship Between Abuse History and Gastrointestinal and Extraintestinal Symptom Severity in Irritable Bowel Syndrome. Psychosom. Med. 2022, 84, 1021–1033. [Google Scholar] [CrossRef]
  53. Fu, Y.; Thomas, R.; Cares, K. Influence of Family History on Children with Irritable Bowel Syndrome. J. Pediatr. Gastroenterol. Nutr. 2021, 72, 866–869. [Google Scholar] [CrossRef] [PubMed]
  54. Singh, M.; Singh, V.; Schurman, J.V.; Colombo, J.M.; Friesen, C.A. The Relationship between Mucosal Inflammatory Cells, Specific Symptoms, and Psychological Functioning in Youth with Irritable Bowel Syndrome. Sci. Rep. 2020, 10, 11988. [Google Scholar] [CrossRef] [PubMed]
  55. Ayonrinde, O.T.; Ayonrinde, O.A.; Adams, L.A.; Sanfilippo, F.M.; O’ Sullivan, T.A.; Robinson, M.; Oddy, W.H.; Olynyk, J.K. The Relationship between Abdominal Pain and Emotional Wellbeing in Children and Adolescents in the Raine Study. Sci. Rep. 2020, 10, 1646. [Google Scholar] [CrossRef] [PubMed]
  56. Di Lorenzo, C.; Youssef, N.N.; Sigurdsson, L.; Scharff, L.; Griffiths, J.; Wald, A. Visceral Hyperalgesia in Children with Functional Abdominal Pain. J. Pediatr. 2001, 139, 838–843. [Google Scholar] [CrossRef]
  57. Ruška, P.; Jerković, A.; Sila, S.; Močić Pavić, A.; Krbot Skorić, M.; Habek, M.; Hojsak, I. Autonomic Nervous System Abnormalities in Children with Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Comparative Study. Clin. Auton. Res. 2025, 35, 591–600. [Google Scholar] [CrossRef]
  58. Hollier, J.M.; Czyzewski, D.I.; Self, M.M.; Liu, Y.; Weidler, E.M.; van Tilburg, M.A.L.; Varni, J.W.; Shulman, R.J. Associations of Abdominal Pain and Psychosocial Distress Measures With Health-Related Quality-of-Life in Pediatric Healthy Controls and Irritable Bowel Syndrome. J. Clin. Gastroenterol. 2021, 55, 422–428. [Google Scholar] [CrossRef]
  59. Iovino, P.; Tremolaterra, F.; Boccia, G.; Miele, E.; Ruju, F.M.; Staiano, A. Irritable Bowel Syndrome in Childhood: Visceral Hypersensitivity and Psychosocial Aspects. Neurogastroenterol. Motil. 2009, 21, 940-e74. [Google Scholar] [CrossRef]
  60. Ganzevoort, I.N.; Berger, M.Y.; Vlieger, A.M.; Benninga, M.A.; De Boer, M.R.; Holtman, G.A. Children with Disorders of Gut-Brain Interaction in Primary Care versus Hospital Care: A Comparison of Characteristics. J. Pediatr. Gastroenterol. Nutr. 2025, 81, 530–539. [Google Scholar] [CrossRef]
  61. Levy, R.L.; Whitehead, W.E.; Walker, L.S.; Von Korff, M.; Feld, A.D.; Garner, M.; Christie, D. Increased Somatic Complaints and Health-Care Utilization in Children: Effects of Parent IBS Status and Parent Response to Gastrointestinal Symptoms. Am. J. Gastroenterol. 2004, 99, 2442–2451. [Google Scholar] [CrossRef]
  62. Hogervorst, E.M.; Ganzevoort, I.N.; Berger, M.Y.; Holtman, G.A. Irritable Bowel Syndrome in Children with Chronic Gastrointestinal Symptoms in Primary Care. Fam. Pract. 2024, 41, 292–298. [Google Scholar] [CrossRef]
  63. Robbertz, A.S.; Nelson, C.I.; Peugh, J.; Hommel, K.; Armistead, L.P.; Cohen, L.L. The Relations Among GI Symptoms, Mental Health, and Online Schooling for Youth With GI Conditions During the COVID-19 Pandemic. J. Dev. Behav. Pediatr. 2026, 47, e54–e58. [Google Scholar] [CrossRef]
Table 1. Demographic data of the patients with IBS.
Table 1. Demographic data of the patients with IBS.
Number of patients24
Age (years)
     mean ± SD
     range

12.7 ± 3.4
5–17 years 6 months
Gender
     Girls
     Boys

17/24 (70.8%)
7/24 (29.2%)
Rank of the child
     first
     second
     third
     eight

12/24 (50%)
10/24 (41.7%)
1/24 (4.2%)
1/24 (4.2%)
Low birth weight (under 2500 g)0/24 (0%)
Family history of IBS2/24 (8.3%)
Family history of psychiatric disorders1/24 (4.2%)
IBS—irritable bowel syndrome.
Table 2. Symptoms, signs, and IBS subtype.
Table 2. Symptoms, signs, and IBS subtype.
Duration of symptoms until evaluated by a pediatric gastroenterologist6 months (median)
Intensity of abdominal pain6.5 (median)
Frequency of abdominal pain
     daily
     once/week
     2 times/week
     3 times/week

17/24 (70.8%)
2/24 (8.3%)
2/24 (8.3%)
3/24 (12.5%)
Duration of abdominal pain
     less than 1 h
     1–2 h
     2–4 h
     continuous

13/24 (54.2%)
6/24 (25%)
2/24 (8.3%)
3/24 (12.5%)
Bloating 14/24 (58.3%)
IBS subtype
     diarrhea
     constipation
     mixed

11/24 (45.8%)
9/24 (37.5%)
4/24 (16.7%)
IBS—irritable bowel syndrome.
Table 3. Psychological and social factors associated with IBS in children.
Table 3. Psychological and social factors associated with IBS in children.
Anxiety
      Performance anxiety
      Social anxiety
      Generalized anxiety
13/24 (54.2%)
6/13
2/13
5/13
Depression3/24 (12.5%)
Panic attacks3/24 (12.5%)
Impaired emotional self-regulation13/24 (54.2%)
Difficulty concentrating5/24 (20.8%)
Difficulty connecting emotionally with others9/24 (37.5%)
Vegetative manifestations in stressful situations 10/24 (41.6%)
Distrust of one’s own strength6/24 (25%)
Body image dissatisfaction2/24 (8.3%)
Sibling rivalry5/24 (20.8%)
Difficulties in adapting to school/kindergarten9/24 (37.5%)
Sleep disturbances2/24 (8.3%)
Family events
     One or both parents working and living abroad
     Illness or death of a family member
     Moving
     Conflicts in the family
     Other potentially traumatizing family events

4/24 (16.6%)
7/24 (29.1%)
3/24 (12.5%)
11/24 (45.8%)
6/24 (25%)
Table 4. Comparison of IBS symptoms in children with and without anxiety.
Table 4. Comparison of IBS symptoms in children with and without anxiety.
With AnxietyWithout Anxietyp
Number of patients with irritable bowel syndromen = 13n = 11 
Intensity of pain
     mean ± SD
     median
     range
     IQR

6.23 ± 0.93
6
5–8
6–7

7.36 ± 2.29
8
3–10
5–9


0.04
Duration of abdominal pain
     less than 1 h
     more than 1 h

6/13 (46.2%)
7/13 (53.8%)

7/11 (63.3%)
4/11 (36.4%)

0.41
Frequency of pain
     daily
     once, twice, or three times/week

9/13 (69.2%)
4/13 (30.8%)

8/11 (72.2%)
3/11 (30.8%)

1
Pain during the day and night
Pain only during the day
8/13 (61.5%)
5/13 (38.5%)
3/11 (27.3%)
8/11 (72.7%)
0.11
IBS subtype
     Diarrhea
     Constipation
     Mixed

5/13 (38.5%)
7/13 (53.8%)
1/13 (7.7%)

6/11 (54.5%)
2/11 (18.2%)
3/11 (27.3%)


0.12
SD—standard deviation, IQR—interquartile range.
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Pop, D.; Aka, I.M.L.; Pop, R.S.; Bota, V.; Farcău, D. Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children. Children 2026, 13, 521. https://doi.org/10.3390/children13040521

AMA Style

Pop D, Aka IML, Pop RS, Bota V, Farcău D. Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children. Children. 2026; 13(4):521. https://doi.org/10.3390/children13040521

Chicago/Turabian Style

Pop, Daniela, Ida Maria Lisa Aka, Radu Samuel Pop, Valentina Bota, and Dorin Farcău. 2026. "Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children" Children 13, no. 4: 521. https://doi.org/10.3390/children13040521

APA Style

Pop, D., Aka, I. M. L., Pop, R. S., Bota, V., & Farcău, D. (2026). Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children. Children, 13(4), 521. https://doi.org/10.3390/children13040521

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