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Volume 11
Issue 8
10.3390/children11080928
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Article

Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience

by
Marius-Cosmin Colceriu
1,2,*,†,
Paul Luchian Aldea
3,†,
Bogdan Bulată
4,
Dan Delean
4,
Alexandra Sevastre-Berghian
1,
Simona Clichici
1,
Andreea-Liana Boț (Răchişan)
2,4,‡ and
Teodora Mocan
1,5,‡
1
Discipline of Physiology, Department of Functional Biosciences, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
2
Second Pediatric Discipline, Department of Mother and Child, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania
3
Discipline of Public Health and Management, Department of Community Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
4
Pediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania
5
Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology, 400158 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors contributed equally to this work.
Children 2024, 11(8), 928; https://doi.org/10.3390/children11080928
Submission received: 1 July 2024 / Revised: 28 July 2024 / Accepted: 30 July 2024 / Published: 31 July 2024
(This article belongs to the Special Issue Kidney Disease in Children: From Bedside to Bench and Back)
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Abstract

Background/Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are the main cause of chronic kidney disease (CKD) requiring renal replacement therapy (RRT) in children, being the leading cause (50–70%) of end-stage renal disease (ESRD) in children and young adults. Our study aimed to assess the natural evolution of various antenatally diagnosed renal malformations and to identify potential prognostic factors to guide the therapeutic management of patients with CAKUT. Methods: We conducted a retrospective study on 205 children with CAKUT. For each patient, analyzing their medical records, we established the nadir value of serum creatinine, defined as the lowest creatinine level during the first year of life. We assessed the value of nadir creatinine as a prognostic marker in patients with CAKUT, and using an ROC curve, we also determined a threshold value of nadir creatinine that predicted progression to ESRD. Results: The male-to-female ratio was 2.8 to 1. The mean gestational age at detection was 29.85 weeks (±6.71). A total of 36 patients (17.6%) had impaired renal function, of which 8 (3.9% of the total) progressed to ESRD. The mean nadir creatinine in patients with ESRD was 1.39 mg/dL. A nadir creatinine cut-off of 0.98 mg/dL had high sensitivity and specificity in identifying patients with progression to ESRD, with an AUC of 0.95 and a 95% confidence interval between 0.86 and 1.05 mg/dL. Conclusions: Our results support the value of nadir creatinine in predicting progression to ESRD, consistent with previously published data.
Keywords: CAKUT; nadir creatinine; children; ESRD CAKUT; nadir creatinine; children; ESRD

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MDPI and ACS Style

Colceriu, M.-C.; Aldea, P.L.; Bulată, B.; Delean, D.; Sevastre-Berghian, A.; Clichici, S.; Boț, A.-L.; Mocan, T. Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience. Children 2024, 11, 928. https://doi.org/10.3390/children11080928

AMA Style

Colceriu M-C, Aldea PL, Bulată B, Delean D, Sevastre-Berghian A, Clichici S, Boț A-L, Mocan T. Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience. Children. 2024; 11(8):928. https://doi.org/10.3390/children11080928

Chicago/Turabian Style

Colceriu, Marius-Cosmin, Paul Luchian Aldea, Bogdan Bulată, Dan Delean, Alexandra Sevastre-Berghian, Simona Clichici, Andreea-Liana Boț (Răchişan), and Teodora Mocan. 2024. "Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience" Children 11, no. 8: 928. https://doi.org/10.3390/children11080928

APA Style

Colceriu, M.-C., Aldea, P. L., Bulată, B., Delean, D., Sevastre-Berghian, A., Clichici, S., Boț, A.-L., & Mocan, T. (2024). Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience. Children, 11(8), 928. https://doi.org/10.3390/children11080928

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