Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators During Childhood or Adolescence †
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Patients Included and Demographics
3.2. Surgical Parameters and Outcomes
3.3. Complications
3.4. PROMs
4. Discussion
Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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N Patients (%) | N LPs (%) | Median (Q1–Q3) Age at Surgery (years) | Median (Q1–Q3) Preoperative LLD (cm) | Median (Q1–Q3) HI (days/cm) | Median (Q1–Q3) TTT (days) | Median (Q1–Q3) Postoperative LLD (cm) | % LPs with One or More Complications | % LPs with One or More Complications (HI > 45 Included) | |
---|---|---|---|---|---|---|---|---|---|
Congenital causes | 41 (82%) | 59 (84%) | 14.8 | 7.0 | 50 | 248 | 1.0 | 42% | 68% |
(11.7–16.0) | (5.0–9.0) | (40–59) | (214–300) | (0.0–2.5) | |||||
Idiopathic | 8 (16%) | 9 (13%) | 15.2 | 4.0 | 62 | 302 | 0.0 | 22% | 100% |
(13.5–16.2) | (4.0–7.0) | (52–67) | (232–318) | (0.0–1.3) | |||||
Proximal hypoplasia CFD | 12 (24%) 11 | 19 (27%) 18 | 15.1 (10.3–15.4) | 7.5 (6.0–9.0) | 51 (42–78) | 223 (209–251) | 1.5 (0.0–3.0) | 44% | 50% |
DDH | 1 | 1 | 11.7 (-) | 9.0 (-) | 63 (-) | 316 (-) | 1.5 (-) | 0% | 100% |
Distal hypoplasia Fibular hemimelia | 17 (34%) 9 | 26 (37%) 18 | 13.4 (8.6–15.9) | 8.0 (6.0–11.0) | 46 (39–54) | 274 (217–283) | 1.5 (1.0–2.0) | 56% | 78% |
Tibial hemimelia | 5 | 5 | 14.8 (14.5–15.9) | 6.0 (5.5–6.0) | 39 (37–45) | 271 (224–278) | 0.0 (0.0–1.0) | 60% | 60% |
CPMBT | 3 | 3 | 15.0 (13.7–15.1) | 4.5 (4.0–5.0) | 42 (36–43) | 211 (182–239) | 0.0 (0.0–0.0) | 0% | 0% |
Skeletal dysplasias | 4 (8%) | 5 (7%) | 16.0 (14.0–16.1) | 5.0 (4.5–9.0) | 47 (37–55) | 256 (192–279) | 1.8 (0.5–3.8) | 40% | 80% |
Ollier’s disease | 1 | 2 | |||||||
CPT without NF1 | 1 | 1 | |||||||
CPT in NF1 | 1 | 1 | |||||||
MHE | 1 | 1 | |||||||
Acquired causes | 9 (18%) | 11 (16%) | 15.6 | 6.0 | 56 | 245 | 0.0 | 27% | 64% |
(14.8–16.4) | (5.0–9.0) | (44–64) | (194–299) | (0.0–0.0) | |||||
Infections | 3 (6%) | 4 (6%) | 14.8 (13.4–15.7) | 9.5 (6.5–10.0) | 67 (50–77) | 376 (270–453) | 1.8 (0.0–3.0) | 25% | 75% |
Trauma | 6 (12%) | 7 (10%) | 16.0 | 5.2 | 52 | 225 | 0.0 | 29% | 57% |
(14.8–16.4) | (5.0–6.0) | (30–60) | (186–265) | (0.0–0.0) | |||||
TOTAL | 50 (100%) | 70 (100%) | 14.9 (12.0–16.0) | 6.3 (5.0–9.0) | 51 (40–60) | 247 (211–299) | 0.4 (0.0–2.0) | 40% | 67% |
Grade According to Lascombes’ Classification | Type of Complication | N |
---|---|---|
Grade I | Superficial infection requiring antibiotics | 14 |
Superficial thrombophlebitis | 1 | |
Temporary nerve palsy | 1 | |
Grade IIa | Early union of regenerate | 1 |
Revision of EF under GA | 1 | |
Grade IIb | - | 0 |
Grade IIIa | HI > 45 days/cm | 38 |
Joint stiffness | 9 | |
Fracture after EF removal | 1 | |
Non-union | 1 | |
Residual angular deformity requiring osteotomy | 2 | |
Grade IIIb | Lengthening procedure interrupted and EF removed | 2 |
Grade IVa | - | 0 |
Grade IVb | - | 0 |
TOTAL | 71 |
PF | RP | BP | GH | VT | SF | RE | MH | PCS | MCS | |
---|---|---|---|---|---|---|---|---|---|---|
Mean | 82 | 86 | 77 | 69 | 61 | 78 | 65 | 63 | 52 | 44 |
Median | 90 | 100 | 80 | 70 | 60 | 75 | 67 | 65 | 54 | 43 |
Range | 5–100 | 0–100 | 35–100 | 25–95 | 30–100 | 25–100 | 0–100 | 16–96 | 29–61 | 24–58 |
PF | RP | BP | GH | VT | SF | RE | MH | PCS | MCS | |
---|---|---|---|---|---|---|---|---|---|---|
Lengthening cycles | 0.14 | −0.07 | 0.04 | −0.07 | 0.09 | 0.01 | −0.04 | −0.10 | 0.06 | −0.09 |
Age at first surgery | −0.05 | −0.09 | 0.06 | −0.12 | 0.05 | −0.10 | −0.10 | −0.10 | −0.03 | −0.06 |
Age at questionnaire | −0.21 | −0.07 | −0.11 | −0.37 * | −0.29 | −0.17 | −0.14 | −0.15 | −0.21 | −0.18 |
Preoperative LLD | −0.14 | −0.09 | −0.31 * | −0.26 | −0.04 | −0.16 | −0.10 | −0.06 | −0.33 * | −0.09 |
Total lengthening | 0.15 | −0.07 | 0.05 | −0.08 | 0.09 | 0.01 | −0.04 | −0.10 | 0.01 | −0.09 |
Complications | 0.05 | −0.15 | 0.08 | −0.05 | −0.01 | 0.13 | −0.06 | −0.25 | 0.08 | −0.19 |
Minor complications | 0.02 | −0.01 | 0.14 | −0.05 | −0.04 | 0.05 | 0.04 | −0.15 | 0.08 | −0.09 |
Major complications | −0.04 | −0.25 | −0.04 | −0.10 | 0.05 | 0.06 | −0.14 | −0.27 | −0.03 | −0.22 |
Total treatment time | −0.08 | −0.21 | −0.23 | −0.23 | −0.01 | −0.18 | −0.28 | −0.19 | −0.14 | −0.27 |
Healing index | −0.22 | −0.13 | −0.25 | −0.17 | −0.12 | −0.21 | −0.27 | −0.18 | −0.23 | −0.27 |
Residual LLD | −0.31 * | −0.20 | −0.28 | −0.28 | −0.15 | −0.23 | −0.20 | −0.17 | −0.34 * | −0.19 |
Follow-up | 0.01 | 0.02 | 0.02 | 0.08 | −0.05 | 0.02 | 0.02 | 0.01 | 0.07 | −0.01 |
Pain | Sleep | Social | PF | Hygiene | Leisure | Work | Future | Emotions | Cosmetic | |
---|---|---|---|---|---|---|---|---|---|---|
Mean | 84 | 73 | 81 | 87 | 96 | 70 | 89 | 73 | 61 | 54 |
Median | 87 | 75 | 88 | 95 | 100 | 75 | 100 | 75 | 60 | 50 |
Range | 46–100 | 13–100 | 25–100 | 8–100 | 25–100 | 0–100 | 13–100 | 25–100 | 15–100 | 10–100 |
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Depaoli, A.; Magnani, M.; Casamenti, A.; Ramella, M.; Menozzi, G.C.; Gallone, G.; Viotto, M.; Rocca, G.; Trisolino, G. Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators During Childhood or Adolescence. Children 2024, 11, 1322. https://doi.org/10.3390/children11111322
Depaoli A, Magnani M, Casamenti A, Ramella M, Menozzi GC, Gallone G, Viotto M, Rocca G, Trisolino G. Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators During Childhood or Adolescence. Children. 2024; 11(11):1322. https://doi.org/10.3390/children11111322
Chicago/Turabian StyleDepaoli, Alessandro, Marina Magnani, Agnese Casamenti, Marco Ramella, Grazia Chiara Menozzi, Giovanni Gallone, Marianna Viotto, Gino Rocca, and Giovanni Trisolino. 2024. "Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators During Childhood or Adolescence" Children 11, no. 11: 1322. https://doi.org/10.3390/children11111322
APA StyleDepaoli, A., Magnani, M., Casamenti, A., Ramella, M., Menozzi, G. C., Gallone, G., Viotto, M., Rocca, G., & Trisolino, G. (2024). Evaluation of Physical and Mental Health in Adults Who Underwent Limb-Lengthening Procedures with Circular External Fixators During Childhood or Adolescence. Children, 11(11), 1322. https://doi.org/10.3390/children11111322