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Review

Microvascular Tissue Engineering—A Review

1
Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
2
Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
3
IRNAS Ltd., Limbuška cesta 78b, 2000 Maribor, Slovenia
*
Authors to whom correspondence should be addressed.
Academic Editor: María García-Díaz
Biomedicines 2021, 9(6), 589; https://doi.org/10.3390/biomedicines9060589
Received: 16 April 2021 / Revised: 14 May 2021 / Accepted: 19 May 2021 / Published: 21 May 2021
(This article belongs to the Special Issue Bioengineered In Vitro Models for Biomedical Applications)
Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges. View Full-Text
Keywords: regenerative medicine; tissue engineering; vascularization; biomaterials; microvascularization; coculture; gradients regenerative medicine; tissue engineering; vascularization; biomaterials; microvascularization; coculture; gradients
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MDPI and ACS Style

Vajda, J.; Milojević, M.; Maver, U.; Vihar, B. Microvascular Tissue Engineering—A Review. Biomedicines 2021, 9, 589. https://doi.org/10.3390/biomedicines9060589

AMA Style

Vajda J, Milojević M, Maver U, Vihar B. Microvascular Tissue Engineering—A Review. Biomedicines. 2021; 9(6):589. https://doi.org/10.3390/biomedicines9060589

Chicago/Turabian Style

Vajda, Jernej, Marko Milojević, Uroš Maver, and Boštjan Vihar. 2021. "Microvascular Tissue Engineering—A Review" Biomedicines 9, no. 6: 589. https://doi.org/10.3390/biomedicines9060589

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