Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas
Abstract
:1. Introduction
2. Experimental Section
2.1. Case Selection
2.2. Immunohistochemistry and Analysis
2.3. Immunofluorescence
2.4. Statistical Analysis
3. Results
3.1. CYP11B1 Expression in ACC Is Low
3.2. CYP11B2 and CYP11B1 Dual Negativity Is Highly Suggestive of Malignant Adrenocortical Tumors
3.3. CYP17A1 Expression in ACC Is Low
3.4. StAR Expression Is Decreased in ACC and ACAn
3.5. ACCs Present Cells That Express Both CYP11B1 and CYP11B2
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Adrenocortical Tumors | Steroidogenic Proteins | Negative | Positive |
---|---|---|---|
ACC (n = 14) | CYP11B1 | 5 (35.7%) | 9 (64.3%) |
CYP11B2 | 11 (78.6%) | 3 (21.4%) | |
CYP17A1 | 0 (0.00%) | 14 (100.0%) | |
StAR | 0 (0.00%) | 14 (100.0%) | |
ACAc (n = 11) | CYP11B1 | 0 (0.00%) | 11 (100.0%) |
CYP11B2 | 5 (45.5%) | 6 (54.5%) | |
CYP17A1 | 0 (0.00%) | 11 (100.0%) | |
StAR | 0 (0.00%) | 11 (100.0%) | |
ACAn (n = 15) | CYP11B1 | 2 (13.3%) | 13 (86.7%) |
CYP11B2 | 7 (46.7%) | 8 (53.3%) | |
CYP17A1 | 1 (6.7%) | 14 (93.3%) | |
StAR | 0 (0.00%) | 15 (100.0%) |
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Pereira, S.S.; Costa, M.M.; Gomez-Sanchez, C.E.; Monteiro, M.P.; Pignatelli, D. Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas. Biomedicines 2020, 8, 256. https://doi.org/10.3390/biomedicines8080256
Pereira SS, Costa MM, Gomez-Sanchez CE, Monteiro MP, Pignatelli D. Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas. Biomedicines. 2020; 8(8):256. https://doi.org/10.3390/biomedicines8080256
Chicago/Turabian StylePereira, Sofia S., Madalena M. Costa, Celso E. Gomez-Sanchez, Mariana P. Monteiro, and Duarte Pignatelli. 2020. "Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas" Biomedicines 8, no. 8: 256. https://doi.org/10.3390/biomedicines8080256