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Open AccessArticle

Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects

1
Laboratório de Farmacologia da Dor e da Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
2
Departamento de Química, Universidade Federal de Sergipe, Sergipe 49100-000, Brazil
3
Instituto de Ciências Exatas, Faculdade de Química, Universidade Federal do Sul e Sudeste do Pará, Marabá 68507-590, Brazil
4
Laboratório de Superfície de Fungos, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(5), 111; https://doi.org/10.3390/biomedicines8050111
Received: 30 March 2020 / Revised: 20 April 2020 / Accepted: 21 April 2020 / Published: 6 May 2020
(This article belongs to the Special Issue Natural Medicine in Therapy)
Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects. View Full-Text
Keywords: Aristolochia trilobata; sulcatyl acetate; antinociceptive effect; anti-inflammatory activity Aristolochia trilobata; sulcatyl acetate; antinociceptive effect; anti-inflammatory activity
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MDPI and ACS Style

Salomé, D.C.; Cordeiro, N.M.; Valério, T.S.; Santos, D.A.; Alves, P.B.; Alviano, C.S.; Moreno, D.S.A.; Fernandes, P.D. Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects. Biomedicines 2020, 8, 111.

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