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Review

Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

1
Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, 18014 Granada, Spain
2
Biosanitary Institute of Granada (ibs.GRANADA), 18014 Granada, Spain
3
Andalusian Network of Design and Translation of Advanced Therapies, 41092 Sevilla, Spain
4
Dermatology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain
5
Dermatology Department, School of Medicine, Granada University, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(11), 464; https://doi.org/10.3390/biomedicines8110464
Received: 9 October 2020 / Revised: 28 October 2020 / Accepted: 29 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Soft and Hard Tissue Regeneration)
This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed. View Full-Text
Keywords: animal experimentation; atopic dermatitis; bioengineered artificial skin substitutes; fibroblasts; product testing; psoriasis; regenerative medicine; tissue engineering; keratinocytes; transepidermal water loss animal experimentation; atopic dermatitis; bioengineered artificial skin substitutes; fibroblasts; product testing; psoriasis; regenerative medicine; tissue engineering; keratinocytes; transepidermal water loss
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MDPI and ACS Style

Sanabria-de la Torre, R.; Fernández-González, A.; Quiñones-Vico, M.I.; Montero-Vilchez, T.; Arias-Santiago, S. Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis. Biomedicines 2020, 8, 464. https://doi.org/10.3390/biomedicines8110464

AMA Style

Sanabria-de la Torre R, Fernández-González A, Quiñones-Vico MI, Montero-Vilchez T, Arias-Santiago S. Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis. Biomedicines. 2020; 8(11):464. https://doi.org/10.3390/biomedicines8110464

Chicago/Turabian Style

Sanabria-de la Torre, Raquel, Ana Fernández-González, María I. Quiñones-Vico, Trinidad Montero-Vilchez, and Salvador Arias-Santiago. 2020. "Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis" Biomedicines 8, no. 11: 464. https://doi.org/10.3390/biomedicines8110464

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