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The Role of Wnt and R-spondin in the Stomach During Health and Disease

Department of Hepatology and Gastroenterology, Charité University Medicine, 10117 Berlin, Germany
Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Berlin Institute of Health, 10117 Berlin, Germany
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(2), 44;
Received: 3 May 2019 / Revised: 7 June 2019 / Accepted: 10 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Gastric Cancer Research: From Basic Science to the Clinic)
PDF [1021 KB, uploaded 19 June 2019]


The Wnt signaling pathway is one of the most prominent developmental signals. In addition to its functions in development, there is emerging evidence that it is also crucial for various organ functions in adult organisms, where Wnt signaling controls tissue stem cell behavior, proliferation and differentiation. Deregulation of Wnt signaling is involved in various pathological conditions and has been linked to malignant tissue transformation in different organ systems. The study of the Wnt signaling pathway has revealed a complex regulatory network that tightly balances the quality and strength of Wnt signaling in tissues. In this context, R-spondins are secreted proteins that stabilize Wnt receptors and enhance Wnt signaling. In this review we focus on new insights into the regulatory function of Wnt and R-spondin signaling in the stomach. In addition to its function in the healthy state, we highlight the connection between Wnt signaling and infection with Helicobacter pylori (H. pylori), a pathogen that colonizes the stomach and is the main risk factor for gastric cancer. In addition to experimental data that link Wnt signaling to carcinogenesis, we discuss that Wnt signaling is affected in a substantial proportion of patients with gastric cancer, and provide examples for potential clinical implications for altered Wnt signaling in gastric cancer. View Full-Text
Keywords: Wnt signaling; gastric cancer; R-spondin; Helicobacter pylori; stem cells; Lgr5+ stem cells; Axin2 Wnt signaling; gastric cancer; R-spondin; Helicobacter pylori; stem cells; Lgr5+ stem cells; Axin2

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fischer, A.-S.; Sigal, M. The Role of Wnt and R-spondin in the Stomach During Health and Disease. Biomedicines 2019, 7, 44.

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