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Viral-Mediated mRNA Degradation for Pathogenesis

MOE& MOH Key Laboratory of Medical Molecular Virology, School of Basic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China
Author to whom correspondence should be addressed.
Equally contributed to this work.
Biomedicines 2018, 6(4), 111;
Received: 1 November 2018 / Revised: 25 November 2018 / Accepted: 29 November 2018 / Published: 29 November 2018
(This article belongs to the Special Issue Viruses in Cancer and Therapy)
PDF [932 KB, uploaded 29 November 2018]


Cellular RNA decay machinery plays a vital role in regulating gene expression by altering the stability of mRNAs in response to external stresses, including viral infection. In the primary infection, viruses often conquer the host cell’s antiviral immune response by controlling the inherently cellular mRNA degradation machinery to facilitate viral gene expression and establish a successful infection. This review summarizes the current knowledge about the diverse strategies of viral-mediated regulatory RNA shutoff for pathogenesis, and particularly sheds a light on the mechanisms that viruses evolve to elude immune surveillance during infection. View Full-Text
Keywords: mRNA degradation; viral pathogenesis mRNA degradation; viral pathogenesis

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Du, S.; Liu, X.; Cai, Q. Viral-Mediated mRNA Degradation for Pathogenesis. Biomedicines 2018, 6, 111.

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