Next Article in Journal
A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses
Previous Article in Journal
Dysregulated Coagulation and Fibrinolysis Are Present in Patients Admitted to the Emergency Department with Acute Hypoxemic Respiratory Failure: A Prospective Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 5
10.3390/biomedicines12051082
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease

by
Tadeusz Dębniak
1,*,
Piotr Baszuk
1,
Ewa Duchnik
2,
Karolina Rowińska
1,
Emilia Rogoża-Janiszewska
1,
Magdalena Boer
2,
Magdalena Kiedrowicz
2,
Mariola Marchlewicz
2,
Daniel Watola
2,
Martyna Feherpataky
1,
Róża Derkacz
3,
Anna Dębniak
1,
Wojciech Marciniak
3,
Katarzyna Gołębiewska
1,
Jan Lubiński
1,
Rodney J. Scott
4 and
Jacek Gronwald
1
1
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 71-252 Szczecin, Poland
2
Department of Skin Diseases and Venerology, Pomeranian Medical University, 72-010 Police, Poland
3
Read-Gene, Grzepnica, 72-003 Dobra, Poland
4
Medical Genetics, School of Biomedical Sciences and Pharmacy, Callaghan, NSW 2308, Australia
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(5), 1082; https://doi.org/10.3390/biomedicines12051082
Submission received: 4 April 2024 / Revised: 6 May 2024 / Accepted: 8 May 2024 / Published: 13 May 2024
(This article belongs to the Section Molecular Genetics and Genetic Diseases)
Versions Notes

Abstract

Using an Inductively Coupled Plasma Mass Spectrometer we measured the concentration of selenium and arsenic in serum and blood samples from 336 unselected psoriatic patients and 336 matched healthy controls to evaluate any associations with the clinical course of the disease. We genotyped 336 patients and 903 matched controls to evaluate the prevalence of SOD2 (rs4880), CAT (rs1001179), GPX1 (rs1050450), and DMGDH (rs921943) polymorphisms using Taqman assays. The mean selenium (Se) level in serum was 74 µg/L in patients and 86 µg/L in controls (p < 0.001). The mean Se level in blood was 95 µg/L in patients and 111 µg/L in controls (p < 0.001). Psoriasis risk was greatest among participants with the lowest serum (<68.75 µg/L, OR: 8.30; p < 0.001) and lowest blood concentrations of Se (<88.04 µg/L, OR: 10.3; p < 0.001). Similar results were observed in subgroups of males and females. We found an inverse correlation of selenium levels with PASI, NAPSI, and BSA scores. There was no significant difference in the distribution of the CAT, GPX1, DMGDH, and SOD2 polymorphisms. Among carriers of rs4880, rs1001179, and rs921943 polymorphisms, blood selenium levels were significantly lower. The mean arsenic level in serum was 0.79 µg/L in patients and 0.7 µg/L in controls (p = 0.2). The mean concentration in blood was 1.1 µg/L in patients and 1.3 µg/L in controls (p < 0.001). In conclusion, we found that lower selenium levels, in blood and serum, are associated with psoriasis risk and its more severe course. Future prospective studies should focus on the optimalisation of the concentration of this trace element not only for prophylactic guidance but also to support the treatment of this disease.
Keywords: psoriasis; serum; selenium; arsenic psoriasis; serum; selenium; arsenic

Share and Cite

MDPI and ACS Style

Dębniak, T.; Baszuk, P.; Duchnik, E.; Rowińska, K.; Rogoża-Janiszewska, E.; Boer, M.; Kiedrowicz, M.; Marchlewicz, M.; Watola, D.; Feherpataky, M.; et al. Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease. Biomedicines 2024, 12, 1082. https://doi.org/10.3390/biomedicines12051082

AMA Style

Dębniak T, Baszuk P, Duchnik E, Rowińska K, Rogoża-Janiszewska E, Boer M, Kiedrowicz M, Marchlewicz M, Watola D, Feherpataky M, et al. Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease. Biomedicines. 2024; 12(5):1082. https://doi.org/10.3390/biomedicines12051082

Chicago/Turabian Style

Dębniak, Tadeusz, Piotr Baszuk, Ewa Duchnik, Karolina Rowińska, Emilia Rogoża-Janiszewska, Magdalena Boer, Magdalena Kiedrowicz, Mariola Marchlewicz, Daniel Watola, Martyna Feherpataky, and et al. 2024. "Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease" Biomedicines 12, no. 5: 1082. https://doi.org/10.3390/biomedicines12051082

APA Style

Dębniak, T., Baszuk, P., Duchnik, E., Rowińska, K., Rogoża-Janiszewska, E., Boer, M., Kiedrowicz, M., Marchlewicz, M., Watola, D., Feherpataky, M., Derkacz, R., Dębniak, A., Marciniak, W., Gołębiewska, K., Lubiński, J., Scott, R. J., & Gronwald, J. (2024). Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease. Biomedicines, 12(5), 1082. https://doi.org/10.3390/biomedicines12051082

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop