Sex and Gender Differences in Iron Chelation

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is a comprehensive and thorough review on aspects of sex and gender differences in the context of iron chelation.  This reviewer has minor suggestions only:

- whereas there is no obvious misinformation detectable to this reviewer, the review is somewhat hard to read.  Structuring overlong sections in smaller portions would be helpful for the reader.

- along with this: a Figure with aspects of iron metabolism and eventual aspects of where sex/gender are known, would be to be considered.

Author Response

This is a comprehensive and thorough review on aspects of sex and gender differences in the context of iron chelation.  This reviewer has minor suggestions only:

Dear Reviewer, thank you very much for the thorough review. We agree to all specific comments addressed and have revised our paper in light of the useful suggestions. Answers to the specific comments/suggestions/queries are as follows.

- whereas there is no obvious misinformation detectable to this reviewer, the review is somewhat hard to read.  Structuring overlong sections in smaller portions would be helpful for the reader.

Thank you for your professional revision. As you suggested, the structure of the manuscript has been revised.

- along with this: a Figure with aspects of iron metabolism and eventual aspects of where sex/gender are known, would be to be considered.

Thank you for your suggestion, we added two figures.

Reviewer 2 Report

Comments and Suggestions for Authors

The manuscript submitted by Allegra et al to Biomedicines focuses the overview on the differences in iron chelation regarding to sex and gender. The text of the manuscript is written well. However, the manuscript has several flaws which should be revised before the acceptance for publication.   

1.  In introduction, the other similar reviews should also be cited.

2. The manuscript has no illustration at all. It should be provided with several representative figures to make it more attractive for the readers.

 

3. The authors should revise the conclusions to answer the key question on the difference on iron chelation in the connection with sex and gender.

Author Response

The manuscript submitted by Allegra et al to Biomedicines focuses the overview on the differences in iron chelation regarding to sex and gender. The text of the manuscript is written well. However, the manuscript has several flaws which should be revised before the acceptance for publication.  

Dear Reviewer, thank you very much for the thorough review. We agree to all specific comments addressed and have revised our paper in light of the useful suggestions. Answers to the specific comments/suggestions/queries are as follows.

1. In introduction, the other similar reviews should also be cited.

Thank you for your expert opinion. The suggested references have been added in the introduction section.

2. The manuscript has no illustration at all. It should be provided with several representative figures to make it more attractive for the readers.

Thank you for your suggestion, we added two figures.

3. The authors should revise the conclusions to answer the key question on the difference on iron chelation in the connection with sex and gender.

Thank you for your revisions. The discussed point has been clarified in the discussion.