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Volume 11
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Article

Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus

by
Trine L. Toft-Bertelsen
1,†,
Søren Norge Andreassen
1,†,
Nina Rostgaard
2,
Markus Harboe Olsen
3,
Nicolas H. Norager
2,
Tenna Capion
2,
Marianne Juhler
2,4 and
Nanna MacAulay
1,*
1
Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark
2
Department of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, Denmark
3
Department of Neuroanaesthesiology, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, Denmark
4
Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomedicines 2023, 11(9), 2360; https://doi.org/10.3390/biomedicines11092360
Submission received: 9 August 2023 / Revised: 21 August 2023 / Accepted: 21 August 2023 / Published: 23 August 2023
(This article belongs to the Section Neurobiology and Clinical Neuroscience)
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Abstract

Patients with subarachnoid hemorrhage (SAH) may develop posthemorrhagic hydrocephalus (PHH), which is treated with surgical cerebrospinal fluid (CSF) diversion. This diversion is associated with risk of infection and shunt failure. Biomarkers for PHH etiology, CSF dynamics disturbances, and potentially subsequent shunt dependency are therefore in demand. With the recent demonstration of lipid-mediated CSF hypersecretion contributing to PHH, exploration of the CSF lipid signature in relation to brain pathology is of interest. Despite being a relatively new addition to the omic’s landscape, lipidomics are increasingly recognized as a tool for biomarker identification, as they provide a comprehensive overview of lipid profiles in biological systems. We here employ an untargeted mass spectroscopy-based platform and reveal the complete lipid profile of cisternal CSF from healthy control subjects and demonstrate its bimodal fluctuation with age. Various classes of lipids, in addition to select individual lipids, were elevated in the ventricular CSF obtained from patients with SAH during placement of an external ventricular drain. The lipidomic signature of the CSF in the patients with SAH suggests dysregulation of the lipids in the CSF in this patient group. Our data thereby reveal possible biomarkers present in a brain pathology with a hemorrhagic event, some of which could be potential future biomarkers for hypersecretion contributing to ventriculomegaly and thus pharmacological targets for pathologies involving disturbed CSF dynamics.
Keywords: cerebrospinal fluid; lipidomics; mass spectrometry; posthemorrhagic hydrocephalus; SAH cerebrospinal fluid; lipidomics; mass spectrometry; posthemorrhagic hydrocephalus; SAH

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MDPI and ACS Style

Toft-Bertelsen, T.L.; Andreassen, S.N.; Rostgaard, N.; Olsen, M.H.; Norager, N.H.; Capion, T.; Juhler, M.; MacAulay, N. Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus. Biomedicines 2023, 11, 2360. https://doi.org/10.3390/biomedicines11092360

AMA Style

Toft-Bertelsen TL, Andreassen SN, Rostgaard N, Olsen MH, Norager NH, Capion T, Juhler M, MacAulay N. Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus. Biomedicines. 2023; 11(9):2360. https://doi.org/10.3390/biomedicines11092360

Chicago/Turabian Style

Toft-Bertelsen, Trine L., Søren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Marianne Juhler, and Nanna MacAulay. 2023. "Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus" Biomedicines 11, no. 9: 2360. https://doi.org/10.3390/biomedicines11092360

APA Style

Toft-Bertelsen, T. L., Andreassen, S. N., Rostgaard, N., Olsen, M. H., Norager, N. H., Capion, T., Juhler, M., & MacAulay, N. (2023). Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus. Biomedicines, 11(9), 2360. https://doi.org/10.3390/biomedicines11092360

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