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Biomedicines
Volume 10
Issue 8
10.3390/biomedicines10081891
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Article

The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer

by
Agnė Bartnykaitė
1,*,
Aistė Savukaitytė
1,
Justina Bekampytė
1,
Rasa Ugenskienė
1,2,
Danguolė Laukaitienė
1,
Erika Korobeinikova
3,
Jurgita Gudaitienė
3 and
Elona Juozaitytė
3
1
Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
2
Department of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
3
Oncology Institute, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(8), 1891; https://doi.org/10.3390/biomedicines10081891
Submission received: 23 June 2022 / Revised: 20 July 2022 / Accepted: 2 August 2022 / Published: 4 August 2022
(This article belongs to the Special Issue Breast Cancer: Future Biomarkers and Personalizing Treatment Approaches)
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Abstract

(1) Background. Breast cancer is the leading cancer type among women. Despite convenient diagnostics at early stages, there is a need for continuous monitoring to predict more aggressive or recurring breast cancer forms. The evidence suggests that the detection of genetic biomarkers could help in improving disease management and reduce mortality. Matrix metalloproteinases (MMPs) are a large family of enzymes that perform physiologically relevant functions and have the potential properties to be biomarkers for cancer assessment. We aimed to evaluate the contribution and association of single-nucleotide polymorphisms (SNPs) in MMP genes (MMP1, MMP2, MMP3, MMP7, MMP8, MMP9) with clinicopathological breast-cancer features. (2) Methods. In this study, 100 breast cancer patients were genotyped by polymerase chain reaction–restriction fragment length polymorphism methodology (PCR–RFLP). (3) Results. The presence of the MMP7 rs11568818 A allele was associated with lower chances for poorly differentiated breast cancer. The lower possibility for HER2-positive breast cancer was associated with the presence of the MMP9 rs3918242 C allele. (4) Conclusions. These results indicate that MMP7 rs11568818 and MMP9 rs3918242 are potential biomarkers for the anticipation of breast cancer aggressiveness.
Keywords: breast cancer; SNP; MMP; association breast cancer; SNP; MMP; association

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MDPI and ACS Style

Bartnykaitė, A.; Savukaitytė, A.; Bekampytė, J.; Ugenskienė, R.; Laukaitienė, D.; Korobeinikova, E.; Gudaitienė, J.; Juozaitytė, E. The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer. Biomedicines 2022, 10, 1891. https://doi.org/10.3390/biomedicines10081891

AMA Style

Bartnykaitė A, Savukaitytė A, Bekampytė J, Ugenskienė R, Laukaitienė D, Korobeinikova E, Gudaitienė J, Juozaitytė E. The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer. Biomedicines. 2022; 10(8):1891. https://doi.org/10.3390/biomedicines10081891

Chicago/Turabian Style

Bartnykaitė, Agnė, Aistė Savukaitytė, Justina Bekampytė, Rasa Ugenskienė, Danguolė Laukaitienė, Erika Korobeinikova, Jurgita Gudaitienė, and Elona Juozaitytė. 2022. "The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer" Biomedicines 10, no. 8: 1891. https://doi.org/10.3390/biomedicines10081891

APA Style

Bartnykaitė, A., Savukaitytė, A., Bekampytė, J., Ugenskienė, R., Laukaitienė, D., Korobeinikova, E., Gudaitienė, J., & Juozaitytė, E. (2022). The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer. Biomedicines, 10(8), 1891. https://doi.org/10.3390/biomedicines10081891

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