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Volume 10
Issue 11
10.3390/biomedicines10112729
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Article

SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma

by
May Wathone Oo
1,
Hotaka Kawai
1,*,
Htoo Shwe Eain
1,2,
Yamin Soe
1,
Kiyofumi Takabatake
1,
Sho Sanou
1,3,
Qiusheng Shan
1,3,
Yasunori Inada
1,
Masae Fujii
1,
Yoko Fukuhara
4,
Ziyi Wang
5,
Shintaro Sukegawa
1,6,
Mitsuaki Ono
5,
Keisuke Nakano
1 and
Hitoshi Nagatsuka
1
1
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
2
Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
3
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
4
Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
5
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
6
Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-0065, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(11), 2729; https://doi.org/10.3390/biomedicines10112729
Submission received: 16 September 2022 / Revised: 26 October 2022 / Accepted: 26 October 2022 / Published: 28 October 2022
(This article belongs to the Special Issue Angiogenesis and Anti-angiogenesis in Health and Diseases)
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Abstract

Tumor angiogenesis is one of the hallmarks of solid tumor development. The progressive tumor cells produce the angiogenic factors and promote tumor angiogenesis. However, how the tumor stromal cells influence tumor vascularization is still unclear. In the present study, we evaluated the effects of oral squamous cell carcinoma (OSCC) stromal cells on tumor vascularization. The tumor stromal cells were isolated from two OSCC patients with different subtypes: low invasive verrucous squamous carcinoma (VSCC) and highly invasive squamous cell carcinoma (SCC) and co-xenografted with the human OSCC cell line (HSC-2) on nude mice. In comparison, the CD34+ vessels in HSC-2+VSCC were larger than in HSC-2+SCC. Interestingly, the vessels in the HSC-2+VSCC expressed vascular endothelial cadherin (VE-cadherin), indicating well-formed vascularization. Our microarray data revealed that the expression of extracellular superoxide dismutase, SOD3 mRNA is higher in VSCC stromal cells than in SCC stromal cells. Moreover, we observed that SOD3 colocalized with VE-cadherin on endothelial cells of low invasive stroma xenograft. These data suggested that SOD3 expression in stromal cells may potentially regulate tumor vascularization in OSCC. Thus, our study suggests the potential interest in SOD3-related vascular integrity for a better OSCC therapeutic strategy.
Keywords: oral squamous cell carcinoma; tumor microenvironment; tumor stroma; tumor vascularization; extracellular superoxide dismutase (SOD3); vascular endothelial cadherin (Ve-cadherin) oral squamous cell carcinoma; tumor microenvironment; tumor stroma; tumor vascularization; extracellular superoxide dismutase (SOD3); vascular endothelial cadherin (Ve-cadherin)

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MDPI and ACS Style

Oo, M.W.; Kawai, H.; Eain, H.S.; Soe, Y.; Takabatake, K.; Sanou, S.; Shan, Q.; Inada, Y.; Fujii, M.; Fukuhara, Y.; et al. SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma. Biomedicines 2022, 10, 2729. https://doi.org/10.3390/biomedicines10112729

AMA Style

Oo MW, Kawai H, Eain HS, Soe Y, Takabatake K, Sanou S, Shan Q, Inada Y, Fujii M, Fukuhara Y, et al. SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma. Biomedicines. 2022; 10(11):2729. https://doi.org/10.3390/biomedicines10112729

Chicago/Turabian Style

Oo, May Wathone, Hotaka Kawai, Htoo Shwe Eain, Yamin Soe, Kiyofumi Takabatake, Sho Sanou, Qiusheng Shan, Yasunori Inada, Masae Fujii, Yoko Fukuhara, and et al. 2022. "SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma" Biomedicines 10, no. 11: 2729. https://doi.org/10.3390/biomedicines10112729

APA Style

Oo, M. W., Kawai, H., Eain, H. S., Soe, Y., Takabatake, K., Sanou, S., Shan, Q., Inada, Y., Fujii, M., Fukuhara, Y., Wang, Z., Sukegawa, S., Ono, M., Nakano, K., & Nagatsuka, H. (2022). SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma. Biomedicines, 10(11), 2729. https://doi.org/10.3390/biomedicines10112729

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