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Volume 10
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10.3390/biomedicines10010075
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Article

Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU

by
Alice Nicoleta Drăgoescu
1,
Vlad Pădureanu
2,*,
Andreea Doriana Stănculescu
1,*,
Luminița Cristina Chiuțu
1,
Paul Tomescu
3,
Cristiana Geormăneanu
4,
Rodica Pădureanu
5,
Vlad Florin Iovănescu
6,
Bogdan Silviu Ungureanu
6,
Andrei Pănuș
3 and
Octavian Petru Drăgoescu
3
1
Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Urology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Department of Internal Medicine, Emergency Clinical County Hospital of Craiova, 200642 Craiova, Romania
6
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
Biomedicines 2022, 10(1), 75; https://doi.org/10.3390/biomedicines10010075
Submission received: 18 July 2021 / Revised: 22 December 2021 / Accepted: 29 December 2021 / Published: 30 December 2021
(This article belongs to the Special Issue Mechanism and Modulation in Sepsis)
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Abstract

Sepsis is a life-threatening medical emergency induced by the body′s extreme response to an infection. Despite well-defined and constantly updated criteria for diagnosing sepsis, it is still underdiagnosed worldwide. Among various markers studied over time, the neutrophil to lymphocyte ratio (NLR) recently emerged as a good marker to predict sepsis severity. Our study was a single-center prospective observational study performed in our ICU and included 114 patients admitted for sepsis or septic shock. Neutrophil to lymphocyte ratio (NLR) is easy to perform, CBC being one of the standard blood tests routinely performed upon admission for all ICU patients. We found that NLR was increased in all patients with sepsis and significantly raised in those with septic shock. NLR correlates significantly with sepsis severity evaluated by the SOFA score (R = 0.65) and also with extensively studied sepsis prognosis marker presepsin (R = 0.56). Additionally, NLR showed good sensitivity (47%) and specificity (78%) with AUC = 0.631 (p < 0.05). NLR is less expensive and easier to perform compared with other specific markers and may potentially become a good alternate option for evaluation of sepsis severity. Larger studies are needed in the future to demonstrate the prognosis value of NLR.
Keywords: neutrophil to lymphocyte ratio (NLR); sepsis; septic shock; presepsin neutrophil to lymphocyte ratio (NLR); sepsis; septic shock; presepsin

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MDPI and ACS Style

Drăgoescu, A.N.; Pădureanu, V.; Stănculescu, A.D.; Chiuțu, L.C.; Tomescu, P.; Geormăneanu, C.; Pădureanu, R.; Iovănescu, V.F.; Ungureanu, B.S.; Pănuș, A.; et al. Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU. Biomedicines 2022, 10, 75. https://doi.org/10.3390/biomedicines10010075

AMA Style

Drăgoescu AN, Pădureanu V, Stănculescu AD, Chiuțu LC, Tomescu P, Geormăneanu C, Pădureanu R, Iovănescu VF, Ungureanu BS, Pănuș A, et al. Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU. Biomedicines. 2022; 10(1):75. https://doi.org/10.3390/biomedicines10010075

Chicago/Turabian Style

Drăgoescu, Alice Nicoleta, Vlad Pădureanu, Andreea Doriana Stănculescu, Luminița Cristina Chiuțu, Paul Tomescu, Cristiana Geormăneanu, Rodica Pădureanu, Vlad Florin Iovănescu, Bogdan Silviu Ungureanu, Andrei Pănuș, and et al. 2022. "Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU" Biomedicines 10, no. 1: 75. https://doi.org/10.3390/biomedicines10010075

APA Style

Drăgoescu, A. N., Pădureanu, V., Stănculescu, A. D., Chiuțu, L. C., Tomescu, P., Geormăneanu, C., Pădureanu, R., Iovănescu, V. F., Ungureanu, B. S., Pănuș, A., & Drăgoescu, O. P. (2022). Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU. Biomedicines, 10(1), 75. https://doi.org/10.3390/biomedicines10010075

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