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Open AccessArticle

SOI-Nanowire Biosensor for the Detection of Glioma-Associated miRNAs in Plasma

1
Institute of Biomedical Chemistry, 119121 Moscow, Russia
2
Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia
3
JSC Novosibirsk Plant of Semiconductor Devices with OKB, 630082 Novosibirsk, Russia
4
Russian Union of Industrialists and Entrepreneurs, 109240 Moscow, Russia
5
Federal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian Federation, 125047 Moscow, Russia
*
Author to whom correspondence should be addressed.
Chemosensors 2020, 8(4), 95; https://doi.org/10.3390/chemosensors8040095
Received: 30 August 2020 / Revised: 23 September 2020 / Accepted: 29 September 2020 / Published: 2 October 2020
(This article belongs to the Section Materials for Chemical Sensing)
Herein, we report the development of a highly sensitive nanotechnology-based system—silicon-on-insulator nanowire biosensor for the revelation of microRNAs (miRNAs), associated with the development of glioma in the human. In this system, a sensor chip, bearing an array of silicon nanowire structures, is employed. The sensor chip is fabricated using a top-down technology. In our experiments reported herein, we demonstrated the detection of DNA oligonucleotide (oDNA), which represents a synthetic analogue of microRNA-363 associated with the development of glioma. To provide biospecific detection of the target oligonucleotides, the surface of the nanowire structures is modified with oligonucleotide probes; the latter are complementary to the target ones. The concentration limit of the target oligonucleotide detection, attained using our nanowire biosensor, is at the level of DL~10−17 M. The revelation of the elevated level of glioma-associated miRNA in plasma is also demonstrated. View Full-Text
Keywords: miRNA; silicon-on-insulator; nanowire biosensor; cancer; glioma; DNA oligonucleotide (oDNA); nanowire miRNA; silicon-on-insulator; nanowire biosensor; cancer; glioma; DNA oligonucleotide (oDNA); nanowire
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Malsagova, K.A.; Pleshakova, T.O.; Galiullin, R.A.; Kozlov, A.F.; Romanova, T.S.; Shumov, I.D.; Popov, V.P.; Tikhonenko, F.V.; Glukhov, A.V.; Smirnov, A.Y.; Gadzhieva, O.A.; Bashiryan, B.A.; Shimansky, V.N.; Archakov, A.I.; Ivanov, Y.D. SOI-Nanowire Biosensor for the Detection of Glioma-Associated miRNAs in Plasma. Chemosensors 2020, 8, 95.

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