Next Article in Journal
Smart Polymers in Micro and Nano Sensory Devices
Next Article in Special Issue
Advances and Perspectives in Chemical Imaging in Cellular Environments Using Electrochemical Methods
Previous Article in Journal
Synthesis, Curing Behavior and Swell Tests of pH-Responsive Coatings from Acryl-Terminated Oligo(β-Amino Esters)
Previous Article in Special Issue
Raman and Surface-Enhanced Raman Scattering for Biofilm Characterization
Article Menu

Export Article

Open AccessFeature PaperReview
Chemosensors 2018, 6(1), 11;

Spectroscopic Chemical Sensing and Imaging: From Plants to Animals and Humans

Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Department of Chemistry, Duke University, Durham, NC 27708, USA
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 16 February 2018 / Accepted: 20 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Advances in Chemical Imaging and its Applications)
Full-Text   |   PDF [2632 KB, uploaded 26 February 2018]   |  


Chemical sensing and imaging technologies are of great importance in medical diagnostics and environmental sensing due to their ability to detect and localize chemical targets and provide valuable information in real-time. Biophotonic techniques are the most promising for in vivo applications due to their minimal invasivity. Our laboratory has introduced various biophotonics-based technologies for chemical sensing and imaging for biochemical sensing, medical diagnostics, and fundamental research. Over the years, we have developed a wide variety of fluorescence and surface-enhanced Raman scattering (SERS)-based technologies for the detection of biomarkers for cancer and other diseases. This paper provides an overview of the research on chemical and biological sensors developed in our laboratory, highlighting our work on in vivo imaging and sensing, including minimally invasive detection of endogenous fluorophores associated with malignant tissue, SERS-tag localization of cancer cells and tissues, and SERS-based detection of nucleic acid biotargets and its feasibility for in vivo applications. This manuscript also presents new development on the use of Raman imaging of SERS-labeled nanoprobes incubated in leaves for use in biofuel research, laying the foundation for studies on functional imaging of nucleic acid biomarkers in plants. View Full-Text
Keywords: sensor; imaging; fluorescence; Raman; surface-enhanced Raman scattering (SERS); plasmonics; nanotechnology sensor; imaging; fluorescence; Raman; surface-enhanced Raman scattering (SERS); plasmonics; nanotechnology

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Strobbia, P.; Odion, R.A.; Vo-Dinh, T. Spectroscopic Chemical Sensing and Imaging: From Plants to Animals and Humans. Chemosensors 2018, 6, 11.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Chemosensors EISSN 2227-9040 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top