SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses
Abstract
:1. Introduction
2. Materials and Methods
2.1. Evolutionary Analysis
2.2. Key Sites Analysis
2.3. Mouse Derived Peptide Analysis
2.4. Allergenicity Assessment and Infection Population Estimating
2.5. Meteorological Parameters Analysis
3. Results
3.1. Phylogenetic Analysis of SARS-CoV-2
3.2. Intermediate Host Analysis
3.3. Analysis of Virus-HLA Binding Affinity for Allergenicity Assessment
3.4. Analysis of Meteorological Factors
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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HLA Class. | Alleles | No. of High Affinity Peptides | % of High Affinity Peptides | No. of Ultrahigh Affinity Peptides | % of Individuals That Have the Specific HLA Allele in the Population of | |
---|---|---|---|---|---|---|
Chinese | American | |||||
I | B*15:03 | 97 | 7.67 | 1 | 0.18 | 2.69 |
I | A*02:03 | 52 | 4.11 | 1 | 8.12 | 1.07 |
I | B*15:17 | 51 | 4.03 | 3 | 0.81 | 0.90 |
I | A*24:03 | 35 | 2.77 | 2 | 0.43 | 0.57 |
I | A*30:01 | 26 | 2.06 | 1 | 14.27 | / |
II | DRB3*03:01 | 998 | 79.59 | 64 | / | 12.72 |
II | DRB1*10:01 | 805 | 64.19 | 30 | 2.75 | 3.41 |
II | DRB1*09:01 | 555 | 44.26 | 9 | 24.28 | 4.94 |
II | DRB1*16:02 | 528 | 42.11 | 14 | 5.15 | 1.96 |
II | DRB1*13:02 | 481 | 38.36 | 38 | 7.58 | 9.56 |
II | DRB1*01:01 | 375 | 29.90 | 8 | 4.14 | 10.75 |
II | DRB1*11:01 | 175 | 13.96 | 2 | 8.49 | / |
ACE2 Comparison | Max Score | Query Coverage | E Value | % of Identities |
---|---|---|---|---|
ACE2-Hs1 vs. ACE2-Hs2 | 1673 | 99% | 0 | 99.01 |
ACE2-Hs1 vs. ACE2-mouse | 1361 | 98% | 0 | 81.05 |
ACE2-Hs1 vs. ACE2-rat | 1353 | 96% | 0 | 82.49 |
ACE2-Hs2 vs. ACE2-mouse | 1369 | 98% | 0 | 81.86 |
ACE2-Hs2 vs. ACE2-rat | 1360 | 98% | 0 | 82.37 |
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Huang, Y.; Xie, J.; Guo, Y.; Sun, W.; He, Y.; Liu, K.; Yan, J.; Tao, A.; Zhong, N. SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses. Healthcare 2021, 9, 1132. https://doi.org/10.3390/healthcare9091132
Huang Y, Xie J, Guo Y, Sun W, He Y, Liu K, Yan J, Tao A, Zhong N. SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses. Healthcare. 2021; 9(9):1132. https://doi.org/10.3390/healthcare9091132
Chicago/Turabian StyleHuang, Yuyi, Junmou Xie, Yuhe Guo, Weimin Sun, Ying He, Kequn Liu, Jie Yan, Ailin Tao, and Nanshan Zhong. 2021. "SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses" Healthcare 9, no. 9: 1132. https://doi.org/10.3390/healthcare9091132