Impact of Alzheimer’s Dementia on Caregivers and Quality Improvement through Art and Music Therapy
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Caregiver Burden
3.2. Music, a Form of Therapy
3.3. Art Therapy
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Walker, M.D.; Salek, S.S.; Bayer, A.J. A Review of Quality of Life in Alzheimer’s Disease. Pharmacol. Econ. 1998, 14, 499–530. [Google Scholar] [CrossRef]
- McKhann, G.M.; Knopman, D.S.; Chertkow, H.; Hyman, B.T.; Jack, C.R., Jr.; Kawas, C.H.; Klunk, W.E.; Koroshetz, W.J.; Manly, J.J.; Mayeux, R.; et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute onAging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011, 7, 263–269. [Google Scholar] [CrossRef][Green Version]
- Gale, S.A.; Acar, D.; Daffner, K.R. Dementia. Am. J. Med. 2018, 131, 1161–1169. [Google Scholar] [CrossRef]
- Michel, J.P.; Zekry, D.; Mulligan, R.; Giacobini, E.; Gold, G. Economic considerations of Alzheimer’s disease and related disorders. Aging 2001, 13, 255–260. [Google Scholar] [CrossRef]
- Barbe, C.; Jolly, D.; Morrone, I.; Wolak-Thierry, A.; Dramé, M.; Novella, J.; Mahmoudi, R. Factors associated with quality of life in patients with Alzheimer’s disease. BMC Geriatr. 2018, 18, 159. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Neugroschl, J.; Wang, S. Alzheimer’s Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity. Mt. Sinai J. Med. 2011, 78, 596–612. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Terry, R.; Davies, P. Dementia of the Alzheimer Type. Annu. Rev. Neurosci. 1980, 3, 77–95. [Google Scholar] [CrossRef] [PubMed]
- Aschbacher, K.; von Känel, R.; Dimsdale, J.E.; Patterson, T.L.; Mills, P.J.; Mausbach, B.T.; Allison, M.A.; Ancoli-Israel, S.; Grant, I. Dementia Severity of the Care Receiver Predicts Procoagulant Response in Alzheimer Caregivers. Am. J. Geriatr. Psychiatry 2006, 14, 694–703. [Google Scholar] [CrossRef]
- Husebo, B.S.; Achterberg, W.; Flo, E. Identifying and Managing Pain in People with Alzheimer’s Disease and Other Types of Dementia: A Systematic Review. CNS Drugs 2016, 30, 481–497. [Google Scholar] [CrossRef][Green Version]
- Post, M.W. Definitions of Quality of Life: What Has Happened and How to Move On. Top. Spinal Cord Inj. Rehabil. 2014, 20, 167–180. [Google Scholar] [CrossRef]
- Olazarán, J.; Reisberg, B.; Clare, L.; Cruz, I.; Peña-Casanova, J.; del Ser, T.; Woods, B.; Beck, C.; Auer, S.; Lai, C.; et al. Nonpharmacological Therapies in Alzheimer’s Disease: A Systematic Review of Efficacy. Dement Geriatr. Cogn. Disord. 2010, 30, 161–178. [Google Scholar] [CrossRef] [PubMed]
- Lee, C.Y.; Cheng, S.J.; Lin, H.O.; Liao, Y.L.; Chen, P.H. Quality of Life in Patients with Dementia with Lewy Bodies. Behav. Neurol. 2018, 2018, 8320901. [Google Scholar] [CrossRef] [PubMed]
- Ferrari, R. Writing narrative style litearture reviews. Med. Writ. 2015, 24, 230–235. [Google Scholar] [CrossRef]
- Iavarone, A.; Ziello, A.R.; Pastore, F.; Fasanaro, A.M.; Poderico, C. Caregiver burden and coping strategies in caregivers of patients with Alzheimer’s disease. Neuropsychiatr. Dis. Treat. 2014, 10, 1407–1413. [Google Scholar] [PubMed][Green Version]
- Chiao, C.Y.; Wu, H.S.; Hsiao, C.Y. Caregiver burden for informal caregivers of patients with dementia: A systematic review. Int. Nurs. Rev. 2015, 62, 340–350. [Google Scholar] [CrossRef] [PubMed]
- Cohen-Mansfield, J.; Werner, P. Typology of disruptive vocalizations in older persons suffering from dementia. Int. J. Geriatr. Psychiatry 1997, 12, 1079–1091. [Google Scholar] [CrossRef]
- Cooke, M.L.; Moyle, W.; Shum, D.H.; Harrison, S.D.; Murfield, J.E. A randomized controlled trial exploring the effect of music on agitated behaviours and anxiety in older people with dementia. Aging Ment. Health 2010, 14, 905–916. [Google Scholar] [CrossRef] [PubMed]
- Brotons, M.; Koger, S.M. The Impact of Music Therapy on Language Functioning in Dementia. J. Music 2000, 37, 183–195. [Google Scholar]
- Li, M.; Lyu, J.-H.; Zhang, Y.; Gao, M.-L.; Li, W.-J.; Ma, X. The clinical efficacy of reminiscence therapy in patients with mild-to-moderate Alzheimer disease. Medicine 2017, 96, e9381. [Google Scholar] [CrossRef]
- Fitzsimmons, S.; Buettner, L.L. Therapeutic recreation interventions for need-driven dementia-compromised. Am. J. Alzheimer’s Dis. Other Dement. 2002, 17, 367–381. [Google Scholar] [CrossRef]
- Remington, R. Calming Music and Hand Massage With Agitated Elderly. Nurs. Res. 2002, 51, 317–323. [Google Scholar] [CrossRef] [PubMed]
- Van de Winckel, A.; Feys, H.; De Weerdt, W.; Dom, R. Cognitive and behavioural effects of music-based exercises in patients with dementia. Clin. Rehabil. 2004, 18, 253–260. [Google Scholar] [CrossRef] [PubMed]
- Sung, H.-c.; Chang, S.-m.; Lee, W.-l.; Lee, M.-s. The effects of group music with movement intervention on agitated behaviours of institutionalized elders with dementia in Taiwan. Complement. Ther. Med 2006, 14, 113–119. [Google Scholar] [CrossRef]
- Schreiner, A.S.; Yamamoto, E.; Shiotani, H. Positive affect among nursing home residents with Alzheimer’s dementia: The effect of recreational activity. Aging Ment Health. 2005, 9, 129–134. [Google Scholar] [CrossRef] [PubMed]
- Svansdottir, H.B.; Snaedal, J. Music therapy in moderate and severe dementia of Alzheimer’s type: A case–control study. Int. Psychogeriatr. 2006, 18, 613–621. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Barca, M.L.; Eldholm, R.S.; Persson, K.; Bjørkløf, G.H.; Borza, T.; Telenius, E.; Knapskog, A.B.; Brækhus, A.; Saltvedt, I.; Selbæk, G.; et al. Cortisol levels among older people with and without depression and dementia. Int. Psychogeriatr. 2018, 31, 597–601. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Ouanes, S.; Popp, J. High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature. Front. Aging Neurosci. 2019, 11, 43. [Google Scholar] [CrossRef]
- Byers, A.; Yaffe, K. Depression and risk of developing dementia. Nat. Rev. Neurol. 2011, 7, 323–331. [Google Scholar] [CrossRef][Green Version]
- Holland, J.M.; Schatzberg, A.F.; O’Hara, R.; Marquette, R.M.; Gallagher-Thompson, D. Pretreatment cortisol levels predict posttreatment outcomes among older adults with depression in cognitive behavioral therapy. Psychiatry Res. 2013, 210, 444–450. [Google Scholar] [CrossRef][Green Version]
- Chu, H.; Yang, C.Y.; Lin, Y.; Ou, K.L.; Lee, T.Y.; O’Brien, A.P.; Chou, K.R. The Impact of Group Music Therapy on Depression and Cognition in Elderly Persons With Dementia. Biol. Res. Nurs. 2014, 16, 209–217. [Google Scholar] [CrossRef]
- Lyu, J.; Zhang, J.; Mu, H.; Li, W.; Champ, M.; Xiong, Q.; Gao, T.; Xie, L.; Jin, W.; Yang, W.; et al. The Effects of Music Therapy on Cognition, Psychiatric Symptoms, and Activities of Daily Living in Patients with Alzheimer’s Disease. J. Alzheimer’s Dis. 2018, 64, 1347–1358. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Ridder, H.M.; Stige, B.; Qvale, L.; Gold, C. Individual music therapy for agitation in dementia: An exploratory randomized controlled trial. Aging Ment. Health 2013, 17, 667–678. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Vink, A.C.; Zuidersma, M.; Boersma, F.; de Jonge, P.; Zuidema, S.U.; Slaets, J.P. The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia: A randomised controlled trial. Int. J. Geriatr. Psychiatry 2012, 28, 1031–1038. [Google Scholar] [CrossRef] [PubMed]
- Demarin, V.; Bedeković, M.R.; Puretić, M.B.; Pašić, M.B. Arts, Brain and Cognition. Psychiatr. Danub. 2016, 28, 343–348. [Google Scholar] [PubMed]
- Deshmukh, S.; Holmes, J.; Cardno, A. Art therapy for people with dementia. Cochrane Database Syst. Rev. 2018, 9, CD011073. [Google Scholar] [CrossRef][Green Version]
- Bolwerk, A.; Mack-Andrick, J.; Lang, F.R.; Dörfler, A.; Maihöfner, C. How Art Changes Your Brain: Differential Effects of Visual Art Production and Cognitive Art Evaluation on Functional Brain Connectivity. PLoS ONE 2014, 9, e101035. [Google Scholar] [CrossRef] [PubMed]
- Mather, K.A.; Jorm, A.F.; Parslow, R.A.; Christensen, H. Is Telomere Length a Biomarker of Aging? A Review. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66A, 202–213. [Google Scholar] [CrossRef] [PubMed]
- Grodstein, F.; van Oijen, M.; Irizarry, M.C.; Rosas, H.D.; Hyman, B.T.; Growdon, J.H.; De Vivo, I. Shorter telomeres may mark early risk of dementia: Preliminary analysis of 62 participants from the Nurses’ Health Study. PLoS ONE 2008, 3, e1590. [Google Scholar] [CrossRef][Green Version]
- Wikgren, M.; Karlsson, T.; Lind, J.; Nilbrink, T.; Hultdin, J.; Sleegers, K.; van Broeckhoven, C.; Roos, G.; Nilsson, L.G.; Nyberg, L.; et al. Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. PLoS ONE 2012, 7, e34292. [Google Scholar] [CrossRef]
- Innes, K.E.; Selfe, T.K.; Brundage, K.; Montgomery, C.; Wen, S.; Kandati, S.; Bowles, H.; Khalsa, D.S.; Huysmans, Z. Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer’s Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial. J. Alzheimer’s Dis. 2018, 66, 947–970. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Van der Steen, J.T.; van Soest-Poortvliet, M.C.; van der Wouden, J.C.; Bruinsma, M.S.; Scholten, R.J.P.M.; Vink, A.C. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst. Rev. 2017, 5, CD003477. [Google Scholar] [CrossRef] [PubMed]
- Rentz, D.M.; Locascio, J.J.; Becker, J.A.; Moran, E.K.; Eng, E.; Buckner, R.L.; Sperling, R.A.; Johnson, K.A. Cognition, reserve, and amyloid deposition in normal aging. Ann. Neurol. 2010, 67, 353–364. [Google Scholar] [CrossRef] [PubMed]
- Hattori, H.; Hattori, C.; Hokao, C.; Mizushima, K.; Mase, T. Controlled study on the cognitive and psychological effect of coloring and drawing in mild Alzheimer’s disease patients. Geriatr. Gerontol. Int. 2011, 11, 431–437. [Google Scholar] [CrossRef]
- Johnson, K.G.; D’Souza, A.A.; Wiseheart, M. Art Training in Dementia: A Randomized Controlled Trial. Front. Psychol. 2020, 11, 585508. [Google Scholar] [CrossRef]
- Flatt, J.D.; Liptak, A.; Oakley, M.A.; Gogan, J.; Varner, T.; Lingler, J.H. Subjective Experiences of an Art Museum Engagement Activity for Persons with Early-Stage Alzheimer’s Disease and Their Family Caregivers. Am. J. Alzheimers Dis. Other Demen. 2015, 30, 380–389. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Eekelaar, C.; Camic, P.M.; Springham, N. Art galleries, episodic memory and verbal fluency in dementia: An exploratory study. Psychol. Aesthet. Creat. Arts 2012, 6, 262–272. [Google Scholar] [CrossRef][Green Version]
- Savazzi, F.; Isernia, S.; Farina, E.; Fioravanti, R.; D’Amico, A.; Saibene, F.L.; Rabuffetti, M.; Gilli, G.; Alberoni, M.; Nemni, R.; et al. “Art, Colors, and Emotions” Treatment (ACE-t): A Pilot Study on the Efficacy of an Art-Based Intervention for People with Alzheimer’s Disease. Front. Psychol. 2020, 11, 1467. [Google Scholar] [CrossRef]
- Chancellor, B.; Duncan, A.; Chatterjee, A. Art therapy for Alzheimer’s disease and other dementias. J. Alzheimer’s Dis. 2014, 39, 1–11. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Soufineyestani, M.; Khan, A.; Sufineyestani, M. Impacts of music intervention on dementia: A review using meta-narrative method and agenda for future research. Neurol. Int. 2021, 13, 1–17. [Google Scholar] [CrossRef]
- Gómez-Romero, M.; Jiménez-Palomares, M.; Rodríguez-Mansilla, J.; Flores-Nieto, A.; Garrido-Ardila, E.M.; González López-Arza, M.V. Beneficios de la musicoterapia en las alteraciones conductuales de la demencia. Revisión sistemática. Neurologia 2017, 32, 253–263. [Google Scholar] [CrossRef]
Alternative Therapy | Diseases or Neurological Disorder | Effects on Patients | Effects on Caregivers | Reference |
---|---|---|---|---|
Group music program | Mild-moderate dementia | Increased verbalization behavior No significant effect on agitation and anxiety | N/A | Cooke M.L., 2010 [17] |
Music or conversation interventions | Dementia | Improvement in speech content and fluency after music sessions | N/A | Brotons M, 2000 [18] |
Reminiscence therapy (including music) | Dementia Alzheimer’s disease | Evaluation of ADAS-Cog, CSDD, NPI, Barthel Index | N/A | Li, M., 2017 [19] |
Home therapeutic recreation intervention | Dementia Agitation Passive behavior | Reduced disturbing behaviors | Respite period communication, emotional support | Fitzsimmons, S.; Buettner, L.L., 2002 [20] |
Calming music, hand massage | Dementia | Reduced agitation | N/A | Remington, R., 2002 [21] |
Music-based exercises | Moderate or severe dementia | Improvement in cognition | N/A | Van de Winckel A., 2004 [22] |
Group music with movement intervention | Dementia | Decreased in agitated behaviours | N/A | Sung, H., 2006 [23] |
Recreational activities (including musical therapy) | Dementia | Icreased mood and level of consciousness | N/A | Schreiner, A.S., 2005 [24] |
Musical therapy | Moderate or severe Alzheimer’s disease | Reduced agitation and anxiety | N/A | Svansdottir HB, Snaedal J., 2006 [25] |
Music therapy | Dementia Depression Cortisol Levels | Reduced depression Improved shot-term recall function | N/A | Chu H., 2014 [30] |
Musical therapy | Dementia | Cognition, psychiatric symptoms, Daily activities | N/A | Lyu J., 2018 [31] |
Music therapy | Dementia | Decreased agitation disruptiveness and psychotopic medication | N/A | Ridder H.M., 2013 [32] |
Music therapy Recreational activities | Dementia | Short-term decrease in agitation | N/A | Vink A.C., 2012 [33] |
Music therapy (ML) Kirtan Kriya meditation (KK) | Dementia Cognitive decline Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels | KK group increases Aβ40, improvement in cognitive and psychosocial status, improvements in stress, mood, QOL | N/A | Innes K.E., 2018 [40] |
Music-based therapeutic interventions | Dementia | Low improvement in depressive symptoms, QOL No improvement in agitation or behavioral disorder | N/A | van der Steen J.T., 2017 [41] |
Study First Author, Year | Design | Study Focus | Intervention Type | Duration | Outcomes Measures |
---|---|---|---|---|---|
Cooke M.L., 2010 [17] | Randomized cross-over controlled study | Dementia | Experimental group: music therapy interventions (listening) | 40 min, three mornings a week for eight weeks | CMAI-SF, RAID |
Brotons M, 2000 [18] | Randomized controlled trial | Alzheimer’s and related disorders | Music therapy vs. conversation sessions | Twice per week for 20–30 min for a total of 8 sessions | MMSE, WAB, AQ |
Li, M., 2017 [19] | Randomized controlled trial | Dementia, Alzheimer’s disease | Reminiscence therapy (including musical therapy) | 35 to 45 min, 2 times/week for 12 consecutive weeks | ADAS-Cog, CSDD, NPI, Barthel Index |
Fitzsimmons, S., Buettner, L.L., 2002 [20] | Quasi-experimental study | Dementia and disturbing behaviors | Individualized recreational therapy interventions | Two weeks of daily, individualized recreational therapy interventions (TRIs) | MMSE, CMAI, Passivity in Dementia Scale |
Remington, R., 2002 [21] | Randomized cross-over controlled study | Dementia, Agitated behavior | Experimental | 10 min exposure to either calming music, hand massage, or calming music and hand massage simultaneously | CMAI, Ward Behavior Inventory, Confusion Inventory |
Van de Winckel A., 2004 [22] | Randomized controlled trial | Dementia | Experimental | 3 months of daily physical exercises supported by music for 30 min/session | MMSE, ADS 6, BOP Scale |
Sung, H., 2006 [23] | Randomized controlled trial | Dementia | Experimental group receiving group music with movement intervention | 30 min, twice a week for 4 weeks | Modified CMAI, Likert Scale |
Schreiner, A.S., 2005 [24] | Randomized control trial | Dementia Alzheimer’s | Structured observation | Structured recreation activities (including musical therapy) | Philadelphia Geriatric Centre Affect Rating Scale, MMSE |
Svansdottir H.B., Snaedal J., 2006 [25] | Case-control study | Moderate or severe Alzheimer’s disease | Experimental group: music therapy interventions | 18 sessions of music therapy, each lasting 30 min, three times a week for 6 weeks | BEHAVE-AD |
Chu H., 2014 [30] | Randomized controlled trial | Dementia, Depression | Experimental group: music therapy interventions (listening, singing, playing instruments) | 30 min sessions/twice a week, 6 weeks | CSDD |
Lyu J, 2018 [31] | Randomized controlled trial | Dementia | Experimental group: music therapy interventions (listening, reading, singing) | 30–40 min, twice a day for three months | MMSE, WHO-UCLA AVLT verbal fluency test, NPI, and Barthel Index |
Ridder H.M., 2013 [32] | Randomized control study | Dementia, Agitation | Experimental group: music therapy interventions (listening, singing, dancing) | On average, 12 sessions of 33.8 min | CMAI, ADRQL, MMSE |
Vink A.C., 2012 [33] | Randomized controlled trial | Dementia | Experimental group: music therapy interventions (listening, singing, dancing, playing an instrument) | 34 sessions, 40 min on average for 4 months | CMAI, GDS |
Innes K.E., 2018 [40] | Randomized controlled trial | Dementia | Kirtan Kriya meditation vs. music listening program | 12-week, 12 min/day | Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels, QOL |
van der Steen J.T., 2017 [41] | Randomized controlled trial | Dementia | Music-based therapeutic interventions | N/A | Emotional well-being and quality of life |
Alternative Therapy | Diseases or Neurological Disorder | Effects on Patients | Effects on Caregivers | Reference |
---|---|---|---|---|
Art therapy vs. calculus | Mild Alzheimer’s disease | Improved QOL and vitality | N/A | Hattori H., 2011 [43] |
Visual art training | Dementia | No quantitative benefits on overall cognition, working memory, or delayed recall | N/A | Johnson K.G., 2020 [44] |
Art activity | Early-stage Alzheimer’s disease or related cognitive disorders (ADRD) | Cognitive stimulation, social connections, improved self-esteem | Social and cultural experience | Flatt, J.D., 2015 [45] |
Art therapy | Dementia | Improvement in episodic memory and fluency, improved mood, confidence, and reduced isolation | Shared experience, support | Eekelaar, C., 2012 [46] |
Art-based interventions | Dementia | Improvement in general cognition and functioning | Mutual support network, active involvement in group activity | Savazzi F., 2020 [47] |
Study First Author, Year | Design | Study Focus | Intervention Type | Duration | Outcomes Measures |
---|---|---|---|---|---|
Hattori H., 2011 [43] | Randomized controlled trial | Dementia, Alzheimer’s disease | Art therapy and control (learning therapy using calculation) groups | Once weekly for 12 weeks | MMSE, QOL, Apathy Scale |
Johnson K.G., 2020 [44] | Randomized controlled trial | Dementia | Visual art training | 1 h/day, 2 days/week, 8 weeks, 16 sessions | MoCA, Backward digit span task |
Flatt, J.D., 2015 [45] | Randomized controlled trial | Early-stage Alzheimer’s disease or related cognitive disorders | Experimental group: art museum engagement activity | Four art engagement activity sessions | Satisfaction survey |
Eekelaar, C., 2012 [46] | Exploratory study | Dementia | Art therapy | Viewing of paintings in a public art gallery, followed by an art-making visual response | MMSE, Semi-structured Interview |
Savazzi F., 2020 [47] | Quasi-experimental design study | Dementia, Alzheimer’s disease | Art-based intervention | 14 sessions | ADAS-Cog, QOL, NPI |
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Popa, L.-C.; Manea, M.C.; Velcea, D.; Șalapa, I.; Manea, M.; Ciobanu, A.M. Impact of Alzheimer’s Dementia on Caregivers and Quality Improvement through Art and Music Therapy. Healthcare 2021, 9, 698. https://doi.org/10.3390/healthcare9060698
Popa L-C, Manea MC, Velcea D, Șalapa I, Manea M, Ciobanu AM. Impact of Alzheimer’s Dementia on Caregivers and Quality Improvement through Art and Music Therapy. Healthcare. 2021; 9(6):698. https://doi.org/10.3390/healthcare9060698
Chicago/Turabian StylePopa, Laura-Cristina, Mihnea Costin Manea, Diana Velcea, Ion Șalapa, Mirela Manea, and Adela Magdalena Ciobanu. 2021. "Impact of Alzheimer’s Dementia on Caregivers and Quality Improvement through Art and Music Therapy" Healthcare 9, no. 6: 698. https://doi.org/10.3390/healthcare9060698