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Volume 9
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10.3390/healthcare9010078
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Case Report

May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia

by
Javier Molina-Cerrillo
1,2,3,*,†,
Juan Marquet-Palomanes
2,4,†,
Teresa Alonso-Gordoa
1,2,3,*,
Javier López-Jiménez
2,3,4 and
Enrique Grande
5
1
Medical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain
2
The Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, 28034 Madrid, Spain
3
Medical School, Alcalá University, 28805 Madrid, Spain
4
Hematology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain
5
MD Anderson Cancer Center, 28033 Madrid, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Healthcare 2021, 9(1), 78; https://doi.org/10.3390/healthcare9010078
Submission received: 8 December 2020 / Revised: 13 January 2021 / Accepted: 14 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Novel Coronavirus (SARS-CoV-2) Outbreak: Epidemiology, Research and Implications for Public Health)
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Abstract

COVID-19 is affecting many countries all around the world. Unfortunately, no treatment has already been approved for the management of patients infected by SARS-CoV-2. It seems that SARS-CoV-2 can induce the activation of an exaggerated immune response against itself according to different mechanisms that are not really well known. Inflammatory interleukins, such as IL-6 among others, play a central role in this uncontrolled immune response. There is a strong rational under ibrutinib use in in the treatment of immune-based diseases, such a as GVHD or RA. Ibrutinib achieves a reduction in the production of TNFα, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. We present our clinical experience about ibrutinib use in ARDS secondary to SARS-CoV-2 in a patient with chronic lymphocytic leukemia (CLL).
Keywords: SARS-CoV-2; COVID19; ibrutinib; BTK SARS-CoV-2; COVID19; ibrutinib; BTK

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MDPI and ACS Style

Molina-Cerrillo, J.; Marquet-Palomanes, J.; Alonso-Gordoa, T.; López-Jiménez, J.; Grande, E. May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia. Healthcare 2021, 9, 78. https://doi.org/10.3390/healthcare9010078

AMA Style

Molina-Cerrillo J, Marquet-Palomanes J, Alonso-Gordoa T, López-Jiménez J, Grande E. May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia. Healthcare. 2021; 9(1):78. https://doi.org/10.3390/healthcare9010078

Chicago/Turabian Style

Molina-Cerrillo, Javier, Juan Marquet-Palomanes, Teresa Alonso-Gordoa, Javier López-Jiménez, and Enrique Grande. 2021. "May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia" Healthcare 9, no. 1: 78. https://doi.org/10.3390/healthcare9010078

APA Style

Molina-Cerrillo, J., Marquet-Palomanes, J., Alonso-Gordoa, T., López-Jiménez, J., & Grande, E. (2021). May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia. Healthcare, 9(1), 78. https://doi.org/10.3390/healthcare9010078

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