A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer

Takagi, Satoshi; Oyama, Takuto; Jimi, Shiro; Saparov, Arman; Ohjimi, Hiroyuki

doi:10.3390/healthcare8040513

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A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer

by

Satoshi Takagi

^1,*

,

Takuto Oyama

¹,

Shiro Jimi

²,

Arman Saparov

³

and

Hiroyuki Ohjimi

¹

Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan

²

Central Lab for Pathology and Morphology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan

³

Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan

^*

Author to whom correspondence should be addressed.

Healthcare 2020, 8(4), 513; https://doi.org/10.3390/healthcare8040513

Submission received: 16 October 2020 / Revised: 15 November 2020 / Accepted: 23 November 2020 / Published: 25 November 2020

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Abstract

Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for initiating wound healing. The case presented is of a patient with a lower leg ulcer that had responded poorly to NPWT alone for three weeks. Consequently, the patient was put on a combination therapy of NPWT and micrografting. After injection of a dermal tissue micrografts suspension into the entire wound bed, NPWT was performed successively for two weeks, resulting in fresh granulation tissue formation. Thereafter, the autologous skin graft was taken well. This case study indicates that for a chronic/refractory ulcer patient with poor NPWT outcome, combination therapy using micrografting treatment and NPWT could rapidly initiate and enhance granulation tissue formation, creating a favorable bedding for subsequent skin grafting.

Keywords: regenerative medicine; chronic wounds; micrografts

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MDPI and ACS Style

Takagi, S.; Oyama, T.; Jimi, S.; Saparov, A.; Ohjimi, H. A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer. Healthcare 2020, 8, 513. https://doi.org/10.3390/healthcare8040513

AMA Style

Takagi S, Oyama T, Jimi S, Saparov A, Ohjimi H. A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer. Healthcare. 2020; 8(4):513. https://doi.org/10.3390/healthcare8040513

Chicago/Turabian Style

Takagi, Satoshi, Takuto Oyama, Shiro Jimi, Arman Saparov, and Hiroyuki Ohjimi. 2020. "A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer" Healthcare 8, no. 4: 513. https://doi.org/10.3390/healthcare8040513

APA Style

Takagi, S., Oyama, T., Jimi, S., Saparov, A., & Ohjimi, H. (2020). A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer. Healthcare, 8(4), 513. https://doi.org/10.3390/healthcare8040513

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer

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