Medical Practitioners’ Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study
Abstract
1. Introduction
2. Factor Choice and Hypotheses
3. Survey Process
4. Empirical Findings
5. Qualitative Findings
6. Limitations
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Alowais, S.A.; Alghamdi, S.S.; Alsuhebany, N.; Alqahtani, T.; Alshaya, A.I.; Almohareb, S.N.; Aldairem, A.; Alrashed, M.; Bin Saleh, K.; Badreldin, H.A.; et al. Revolutionizing healthcare: The role of artificial intelligence in clinical practice. BMC Med. Educ. 2023, 23, 689. [Google Scholar] [CrossRef] [PubMed]
- Hamet, P.; Tremblay, J. Artificial intelligence in medicine. Metabolism 2017, 69, S36–S40. [Google Scholar] [CrossRef] [PubMed]
- Jiang, F.; Jiang, Y.; Zhi, H.; Dong, Y.; Li, H.; Ma, S.; Wang, Y.; Dong, Q.; Shen, H.; Wang, Y. Artificial intelligence in healthcare: Past, present and future. Stroke Vasc. Neurol. 2017, 2, e000101. [Google Scholar] [CrossRef]
- Miller, D.D.; Brown, E.W. Artificial intelligence in medical practice: The question to the answer? Am. J. Med. 2018, 131, 129–133. [Google Scholar] [CrossRef]
- Kong, M.; He, Q.; Li, L. Research on the development status and strategy of artificial intelligence assisted diagnosis and treatment. Strateg. Study Chin. Acad. Eng. 2018, 20, 86–91. [Google Scholar]
- Sallam, M.; Snygg, J.; Allam, D.; Kassem, R.; Damani, M. Artificial intelligence in clinical medicine: A SWOT analysis of AI progress in diagnostics, therapeutics, and safety. J. Innov. Med. Res. 2025, 4, 1–20. [Google Scholar] [CrossRef]
- Yang, M.; Long, D.; Chi, H.; Bai, Z.; Ji, Y. Research progress of artificial intelligence-based clinical decision support system in obstetrics. Clin. Med. Res. Pract. 2023, 8, 190–193. (In Chinese) [Google Scholar] [CrossRef]
- Government of China. Notice of the State Council on Printing and Distributing the Development Plan for the New Generation of Artificial Intelligence. 2017. Available online: https://www.gov.cn/zhengce/content/2017-07/20/content_5211996.htm (accessed on 7 May 2025). (In Chinese)
- Fan, W.; Liu, J.; Zhu, S.; Pardalos, P.M. Investigating the impacting factors for the healthcare professionals to adopt artificial intelligence-based medical diagnosis support system (AIMDSS). Ann. Oper. Res. 2020, 294, 567–592. [Google Scholar] [CrossRef]
- Prakash, A.V.; Das, S. Medical practitioner’s adoption of intelligent clinical diagnostic decision support systems: A mixed-methods study. Inf. Manag. 2021, 58, 103524. [Google Scholar] [CrossRef]
- Jin, C.; He, D. Application and challenges of artificial intelligence in the field of medical and health care. J. Health Econ. 2018, 11, 3–6. (In Chinese) [Google Scholar] [CrossRef]
- Tong, Y.; Tan, C.-H.; Sia, C.L.; Shi, Y.; Teo, H.-H. Rural-Urban Healthcare Access Inequality Challenge: Transformative Roles of Information Technology. MIS Q. 2022, 46, 1937–1985. [Google Scholar] [CrossRef]
- Li, D.; Chao, J.; Kong, J.; Cao, G.; Lv, M.; Zhang, M. The efficiency analysis and spatial implications of health information technology: A regional exploratory study in China. Health Inform. J. 2020, 26, 1700–1713. [Google Scholar] [CrossRef] [PubMed]
- Jeilani, A.; Hussein, A. Impact of Digital Health Technologies Adoption on Healthcare Workers’ Performance and Workload: Perspective with DOI and TOE Models. BMC Health Serv. Res. 2025, 25, 271. [Google Scholar] [CrossRef] [PubMed]
- Lambert, S.I.; Madi, M.; Sopka, S.; Lenes, A.; Stange, H.; Buszello, C.-P.; Stephan, A. An integrative review on the acceptance of artificial intelligence among healthcare professionals in hospitals. npj Digit. Med. 2023, 6, 111. [Google Scholar] [CrossRef]
- Yang, Y.; Ngai, E.W.; Wang, L. Resistance to artificial intelligence in health care: Literature review, conceptual framework, and research agenda. Inf. Manag. 2024, 61, 103961. [Google Scholar] [CrossRef]
- Hameed, B.-M.Z.; Naik, N.; Ibrahim, S.; Tatkar, N.S.; Shah, M.J.; Prasad, D.; Hegde, P.; Chlosta, P.; Rai, B.P.; Somani, B.K. Breaking Barriers: Unveiling Factors Influencing the Adoption of Artificial Intelligence by Healthcare Providers. Big Data Cogn. Comput. 2023, 7, 105. [Google Scholar] [CrossRef]
- Shinners, L.; Aggar, C.; Grace, S.; Smith, S. Exploring healthcare professionals’ understanding and experiences of artificial intelligence technology use in the delivery of healthcare: An integrative review. Health Inform. J. 2020, 26, 1225–1236. [Google Scholar] [CrossRef]
- Yang, X.; Man, D.; Yun, K.; Zhang, S.; Han, X. Factors influencing doctors’ acceptance of artificial intelligence-enabled clinical decision support systems in tertiary hospitals in China. Res. Sq. 2023. [Google Scholar] [CrossRef]
- Venkatesh, V.; Morris, M.G.; Davis, G.B.; Davis, F.D. User acceptance of information technology: Toward a unified view. MIS Q. 2003, 27, 425–478. [Google Scholar] [CrossRef]
- Venkatesh, V.; Davis, F.D.; Morris, M.G. Dead or alive? The development, trajectory and future of technology adoption research. J. Assoc. Inf. Syst. 2007, 8, 267–286. [Google Scholar] [CrossRef]
- Venkatesh, V.; Thong, J.L.; Xu, X. Consumer Acceptance and Use of Information Technology: Extending the Unified Theory of Acceptance and Use of Technology. MIS Q. 2012, 36, 157–178. [Google Scholar] [CrossRef]
- Joachim, V.; Spieth, P.; Heidenreich, S. Active innovation resistance: An empirical study on functional and psychological barriers to innovation adoption in different contexts. Ind. Mark. Manag. 2018, 71, 95–107. [Google Scholar] [CrossRef]
- Kim, H.-W.; Chan, H.C.; Gupta, S. Value-based adoption of mobile internet: An empirical investigation. Decis. Support Syst. 2007, 43, 111–126. [Google Scholar] [CrossRef]
- Featherman, M. Is Perceived Risk Germane to Technology Acceptance Research? In Awe; AIS Elibrary: Boston, MA, USA, 2001. [Google Scholar]
- Schwesig, R.; Brich, I.; Buder, J.; Huff, M.; Said, N. Using artificial intelligence (AI)? Risk and opportunity perception of AI predict people’s willingness to use AI. J. Risk Res. 2023, 26, 1053–1084. [Google Scholar] [CrossRef]
- Agarwal, R.; Prasad, J. A Conceptual and Operational Definition of Personal Innovativeness in the Domain of Information Technology. Inf. Syst. Res. 1998, 9, 204–224. [Google Scholar] [CrossRef]
- Weik, L.; Fehring, L.; Mortsiefer, A.; Meister, S. Understanding Inherent Influencing Factors to Digital Health Adoption in General Practices Through a Mixed-Methods Analysis. npj Digit. Med. 2024, 7, 47. [Google Scholar] [CrossRef]
- Choi, J.K.; Ji, Y.G. Investigating the importance of trust on adopting an autonomous vehicle. Int. J. Hum. Comput. Interact. 2015, 31, 692–702. [Google Scholar] [CrossRef]
- Panicker, R.O.; Soman, B.; Gangadharan, K.V.; Sobhana, N.V. An adoption model describing clinician’s acceptance of automated diagnostic system for tuberculosis. Health Technol. 2016, 6, 247–257. [Google Scholar] [CrossRef]
- Bhattacherjee, A.; Hikmet, N. Physicians’ resistance toward healthcare information technology: A theoretical model and empirical test. Eur. J. Inf. Syst. 2007, 16, 725–737. [Google Scholar] [CrossRef]
- Polites, G.L.; Karahanna, E. Shackled to the status quo: The inhibiting effects of incumbent system habit, switching costs, and inertia on new system acceptance. MIS Q. 2012, 36, 21–42. [Google Scholar] [CrossRef]
- Herzberg, F. Work and the Nature of Man; World Publishing Company: Cleveland, OH, USA, 1966. [Google Scholar]
- Hsieh, P.-J.; Lin, W.-S. Explaining resistance to system usage in the PharmaCloud: A view of the dual-factor model. Inf. Manag. 2018, 55, 51–63. [Google Scholar] [CrossRef]
- Cenfetelli, R.T. Inhibitors and enablers as dual factor concepts in technology usage. J. Assoc. Inf. Syst. 2004, 5, 472–492. [Google Scholar] [CrossRef]
- Buck, C.; Doctor, E.; Hennrich, J.; Jöhnk, J.; Eymann, T. General practitioners’ attitudes toward artificial intelligence–enabled systems: Interview study. J. Med Internet Res. 2022, 24, e28916. [Google Scholar] [CrossRef] [PubMed]
- Helenason, J.; Ekström, C.; Falk, M.; Papachristou, P. Exploring the feasibility of an artificial intelligence based clinical decision support system for cutaneous melanoma detection in primary care—A mixed method study. Scand. J. Prim. Health Care 2023, 42, 51–60. [Google Scholar] [CrossRef] [PubMed]
- Choudhury, A. Factors influencing clinicians’ willingness to use an AI-based clinical decision support system. Front. Digit. Health 2022, 4, 920662. [Google Scholar] [CrossRef]
- Lu, Z.; Cui, T.; Tong, Y.; Wang, W. Examining the effects of social influence in pre-adoption phase and initial post-adoption phase in the healthcare context. Inf. Manag. 2020, 57, 103195. [Google Scholar] [CrossRef]
- Floruss, J.; Vahlpahl, N. Artificial Intelligence in Healthcare: Acceptance of AI-Based Support Systems by Healthcare Professionals. Master’s Thesis, Jönköping University, Jönköping, Sweden, 2020. [Google Scholar]
- McKnight, D.H.; Choudhury, V.; Kacmar, C. Developing and validating trust measures for e-commerce: An integrative typology. Inf. Syst. Res. 2002, 13, 334–359. [Google Scholar] [CrossRef]
- Li, X.; Hess, T.J.; Valacich, J.S. Why do we trust new technology? A study of initial trust formation with organizational information systems. J. Strateg. Inf. Syst. 2008, 17, 39–71. [Google Scholar] [CrossRef]
- Adebesin, F.; Mwalugha, R. The mediating role of organizational reputation and trust in the intention to use wearable health devices: Cross-country study. JMIR mHealth uHealth 2020, 8, e16721. [Google Scholar] [CrossRef] [PubMed]
- Li, R.; Shi, B. Application and transformation of medical injury liability rules from the perspective of artificial intelligence. J. Shenzhen Univ. (Humanit. Soc. Sci.) 2019, 36, 91–99. (In Chinese) [Google Scholar]
- Shibl, R.; Lawley, M.; Debuse, J. Factors influencing decision support system acceptance. Decis. Support Syst. 2013, 54, 953–961. [Google Scholar] [CrossRef]
- Sambasivan, M.; Esmaeilzadeh, P.; Kumar, N.; Nezakati, H. Intention to adopt clinical decision support systems in a developing country: Effect of Physician’s perceived professional autonomy, involvement and belief: A cross-sectional study. BMC Med. Inform. Decis. Mak. 2012, 12, 142. [Google Scholar] [CrossRef] [PubMed]
- Vu, H.T.; Lim, J. Effects of country and individual factors on public acceptance of artificial intelligence and robotics technologies: A multilevel SEM analysis of 28-country survey data. Behav. Inf. Technol. 2021, 41, 1515–1528. [Google Scholar] [CrossRef]
- Pedro, A.R.; Dias, M.B.; Laranjo, L.; Cunha, A.S.; Cordeiro, J.V. Artificial intelligence in medicine: A comprehensive survey of medical doctor’s perspectives in Portugal. PLoS ONE 2023, 18, e0290613. [Google Scholar] [CrossRef]
- Shinners, L.; Aggar, C.; Stephens, A.; Grace, S. Healthcare professionals’ experiences and perceptions of artificial intelligence in regional and rural health districts in Australia. Aust. J. Rural Health 2023, 31, 1203–1213. [Google Scholar] [CrossRef] [PubMed]
- Tran, A.Q.; Nguyen, L.H.; Nguyen, H.S.A.; Nguyen, C.T.; Vu, L.G.; Zhang, M.; Vu, T.M.T.; Nguyen, S.H.; Tran, B.X.; Latkin, C.A.; et al. Determinants of intention to use artificial intelligence-based diagnosis support system among prospective physicians. Front. Public Health 2021, 9, 755644. [Google Scholar] [CrossRef]
- Wu, I.-L.; Li, J.-Y.; Fu, C.-Y. The adoption of mobile heathcare by hospital’s professionals: An integrative perspective. Decis. Support Syst. 2011, 51, 587–596. [Google Scholar] [CrossRef]
- Lankton, N.K.; McKnight, D.H.; Tripp, J. Technology, humanness, and trust: Rethinking trust in technology. J. Assoc. Inf. Syst. 2015, 16, 880–918. [Google Scholar] [CrossRef]
- Chung, J.; Zink, A. Hey Watson—Can I sue you for malpractice? Examining the liability of artificial intelligence in medicine. Asia Pac. J. Health Law Ethics 2018, 11, 51–80. [Google Scholar]
- Zhang, S. Application of logit regression model in medicine. Sci. Technol. Vis. 2013, 5, 105. (In Chinese) [Google Scholar] [CrossRef]
- Dong, Y.; Xu, F. An application of logistic regression model in medicine. Pract. Underst. Math. 2012, 42, 73–77. [Google Scholar]
- Castillo-Montoya, M. Preparing for Interview Research: The Interview Protocol Refinement Framework. Qual. Rep. 2016, 21, 811–831. [Google Scholar] [CrossRef]
- Brommeyer, M.; Whittaker, M.; Liang, Z. Organizational Factors Driving the Realization of Digital Health Transformation Benefits from Health Service Managers: A Qualitative Study. J. Healthc. Leadersh. 2024, 16, 455–472. [Google Scholar] [CrossRef]
- Pattanaik, P.K.; Gupta, S.; Pani, A.K.; Himanshu, U.; Pappas, I.O. Impact of Inter and Intra Organizational Factors in Healthcare Digitalization: A Conditional Mediation Analysis. Inf. Syst. Front. 2025, 27, 1275–1302. [Google Scholar] [CrossRef]
- Sallam, M.; Al-Adwan, A.S.; Mijwil, M.M.; Abdelaziz, D.H.; Al-Qaisi, A.; Ibrahim, O.M.; Sallam, M. Technology Readiness, Social Influence, and Anxiety as Predictors of University Educators’ Perceptions of Generative AI Usefulness and Effectiveness. J. Educ. Dev. 2025, 9, 1–29. [Google Scholar] [CrossRef]
- Faiz, F.; Le, V.; Masli, E.K. Determinants of Digital Technology Adoption in Innovative SMEs. J. Innov. Knowl. 2024, 9, 100610. [Google Scholar] [CrossRef]
- Sarwar, S.; Dent, A.; Faust, K.; Richer, M.; Djuric, U.; Van Ommeren, R.; Diamandis, P. Physician perspectives on integration of artificial intelligence into diagnostic pathology. npj Digit. Med. 2019, 2, 28. [Google Scholar] [CrossRef]
- Hsieh, P.-J. An empirical investigation of patients’ acceptance and resistance toward the health cloud: The dual factor perspective. Comput. Hum. Behav. 2016, 63, 959–969. [Google Scholar] [CrossRef]
- Ye, T.; Xue, J.; He, M.; Gu, J.; Lin, H.; Xu, B.; Cheng, Y. Psychosocial Factors Affecting Artificial Intelligence Adoption in Health Care in China: Cross-Sectional Study. J. Med. Internet Res. 2019, 21, e14316. [Google Scholar] [CrossRef] [PubMed]
- Castagno, S.; Khalifa, M. Perceptions of artificial intelligence among healthcare staff: A qualitative survey study. Front. Artif. Intell. 2020, 3, 578983. [Google Scholar] [CrossRef] [PubMed]
- Romero-Brufau, S.; Wyatt, K.D.; Boyum, P.; Mickelson, M.; Moore, M.; Cognetta-Rieke, C. A lesson in implementation: A pre-post study of providers’ experience with artificial intelligence-based clinical decision support. Int. J. Med. Inform. 2020, 137, 104072. [Google Scholar] [CrossRef] [PubMed]
- Wang, D.; Wang, L.; Zhang, Z.; Wang, D.; Zhu, H.; Gao, Y.; Fan, X.; Tian, F. “Brilliant AI doctor” in rural clinics: Challenges in AI-powered clinical decision support system deployment. In Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems, Yokohama, Japan, 8–13 May 2021; p. 697. [Google Scholar] [CrossRef]
- Longoni, C.; Bonezzi, A.; Morewedge, C.K. Resistance to Medical Artificial Intelligence. J. Consum. Res. 2019, 46, 629–650. [Google Scholar] [CrossRef]
- Huo, W.; Zhang, Z.; Qu, J.; Yan, J.; Yan, S.; Yan, J.; Shi, B. Speciesism and Preference of Human–Artificial Intelligence Interaction: A Study on Medical Artificial Intelligence. Int. J. Hum. Comput. Interact. 2023, 40, 2925–2937. [Google Scholar] [CrossRef]
- Antes, A.L.; Burrous, S.; Sisk, B.A.; Schuelke, M.J.; Keune, J.D.; DuBois, J.M. Exploring perceptions of healthcare technologies enabled by artificial intelligence: An online, scenario-based survey. BMC Med. Inform. Decis. Mak. 2021, 21, 221. [Google Scholar] [CrossRef]
- Chen, M.; Zhang, B.; Cai, Z.; Seery, S.; Gonzalez, M.J.; Ali, N.M.; Ren, R.; Qiao, Y.; Xue, P.; Jiang, Y. Acceptance of clinical artificial intelligence among physicians and medical students: A systematic review with cross-sectional survey. Front. Med. 2022, 9, 990604. [Google Scholar] [CrossRef]
- Catalina, Q.M.; Fuster-Casanovas, A.; Vidal-Alaball, J.; Escalé-Besa, A.; Marin-Gomez, F.X.; Femenia, J.; Solé-Casals, J. Knowledge and perception of primary care healthcare professionals on the use of artificial intelligence as a healthcare tool. Digit. Health 2023, 9, 20552076231180511. [Google Scholar] [CrossRef] [PubMed]
| Variable | Category | Frequency | Percentage |
|---|---|---|---|
| Gender | Male | 44 | 26.50 |
| Female | 122 | 73.50 | |
| Age group | 18–25 | 38 | 22.90 |
| 26–30 | 28 | 16.90 | |
| 31–40 | 39 | 23.50 | |
| 41–50 | 52 | 31.30 | |
| >50 | 9 | 5.40 | |
| Years of employment as a doctor | Medical students | 33 | 19.88 |
| <5 | 30 | 18.07 | |
| 5–15 | 37 | 22.29 | |
| 15–20 | 12 | 7.23 | |
| 20–25 | 22 | 13.25 | |
| >25 | 32 | 19.28 | |
| Hospital role | Clinical (directly diagnose and treat patients) | 128 | 77.1 |
| Non-clinical (provide treatment and administrative support) | 38 | 22.9 | |
| Total | 166 | 100 |
| Variable | Mean (Intenders, n = 133) | Mean (Non-Intenders, n = 33) | t-Value | p-Value |
|---|---|---|---|---|
| Performance Expectancy | 4.25 | 4.16 | 0.62 | 0.537 |
| Effort Expectancy | 3.91 | 3.75 | 0.94 | 0.349 |
| Social Impact | 4.07 | 3.78 | 1.92 | 0.056 |
| Initial Trust | 4.11 | 4.06 | 0.32 | 0.747 |
| Elemental Trust | 4.04 | 3.87 | 1.15 | 0.253 |
| Perceived Risk | 1.86 | 1.9 | −0.3 | 0.762 |
| Perceived Threat | 2.17 | 2.28 | −0.66 | 0.509 |
| Category | Cronbach’s Alpha | Cronbach’s Alpha Based on Standardized Items | N of Items |
|---|---|---|---|
| Total Sample | 0.951 | 0.957 | 34 |
| Key Variables (Influencing Factors) | 0.966 | 0.968 | 30 |
| B | S.E. | Wald | df | Sig. | Exp (B) | 95% C.I. of EXP (B) | |||
|---|---|---|---|---|---|---|---|---|---|
| Lower Limit | Upper Limit | ||||||||
| Step 1a | Performance expectations | −0.097 | 0.489 | 0.039 | 1 | 0.843 | 0.908 | 0.348 | 2.365 |
| Expectation of effort | −0.031 | 0.327 | 0.009 | 1 | 0.923 | 0.969 | 0.510 | 1.840 | |
| Social influence | 1.154 | 0.522 | 4.894 | 1 | 0.027 | 3.172 | 1.141 | 8.818 | |
| General trust tendencies | 0.329 | 0.460 | 0.510 | 1 | 0.475 | 1.389 | 0.564 | 3.426 | |
| Initial trust perception | −1.265 | 0.709 | 3.179 | 1 | 0.075 | 0.282 | 0.070 | 1.134 | |
| Perceived risk | 0.089 | 0.397 | 0.051 | 1 | 0.822 | 1.093 | 0.503 | 2.378 | |
| Perceived threats | −0.012 | 0.277 | 0.002 | 1 | 0.965 | 0.988 | 0.574 | 1.701 | |
| M act intent | 0.231 | 0.375 | 0.378 | 1 | 0.539 | 1.260 | 0.603 | 2.629 | |
| constant | 0.182 | 2.239 | 0.007 | 1 | 0.935 | 1.200 | |||
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Zhu, R.; Huo, Z.; Li, Y.; Gao, B.; Krever, R. Medical Practitioners’ Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study. Healthcare 2026, 14, 1096. https://doi.org/10.3390/healthcare14081096
Zhu R, Huo Z, Li Y, Gao B, Krever R. Medical Practitioners’ Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study. Healthcare. 2026; 14(8):1096. https://doi.org/10.3390/healthcare14081096
Chicago/Turabian StyleZhu, Runping, Zunbin Huo, Yue Li, Banlinxin Gao, and Richard Krever. 2026. "Medical Practitioners’ Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study" Healthcare 14, no. 8: 1096. https://doi.org/10.3390/healthcare14081096
APA StyleZhu, R., Huo, Z., Li, Y., Gao, B., & Krever, R. (2026). Medical Practitioners’ Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study. Healthcare, 14(8), 1096. https://doi.org/10.3390/healthcare14081096

