Cross-Cultural Adaptation and Psychometric Testing of the Italian Barriers to Nursing Research Participation (I-BNPRQ)
Highlights
- The Italian Barriers to Nurses’ Participation in Research Questionnaire (I-BNPRQ) was cross-culturally adapted for the Italian cultural and organisational healthcare context and showed preliminary evidence of structural validity, internal consistency, and temporal stability.
- The final Italian version retained a two-factor structure but required culturally and psychometrically justified item-level refinements, including the exclusion of items with weak contribution to the latent structure and the merging of two conceptually overlapping items.
- The questionnaire may support the identification of organisational and individual barriers to nurses’ research participation in the Italian context.
- Targeted institutional strategies, protected research time, and research education may help strengthen nurses’ engagement in research and, consequently, evidence-based care.
Abstract
1. Introduction
2. Materials and Methods
2.1. Design
2.2. Measures
2.2.1. Barriers to Nurses’ Participation in the Research Questionnaire
2.2.2. Translation and Cross-Cultural Adaptation
2.2.3. Content Validity
2.2.4. Data Collection
2.3. Statistical Analyses
Sample Size Calculation
2.4. Ethical Consideration
3. Results
3.1. Content Validity
3.2. Structural Validity
3.3. Reliability
3.4. Item Descriptive Statistics
3.5. Associations Between Sample Characteristics and Perceived Barriers
3.5.1. Associations with Socio-Demographic and Professional Characteristics
3.5.2. Associations with Research Training
4. Discussion
4.1. Implications for Clinical Practice
4.2. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| BNPRQ | Barriers to Nurses’ Participation in Research Questionnaire |
| CFA | Confirmatory Factor Analysis |
| CFI | Comparative Fit Index |
| CI | Confidence Interval |
| CVR | Content Validity Ratio |
| EFA | Exploratory Factor Analysis |
| ESEM | Exploratory Structural Equation Modelling |
| GLM | Generalised Linear Model |
| I-BNPRQ | Italian Barriers to Nurses’ Participation in Research Questionnaire |
| ICC | Intraclass Correlation Coefficient |
| IQR | Interquartile Range |
| IRCCS | Scientific Institute for Research, Hospitalisation and Healthcare |
| KMO | Kaiser–Meyer–Olkin |
| MLR | Maximum Likelihood Robust |
| PI | Principal Investigator |
| RMSEA | Root Mean Square Error of Approximation |
| SD | Standard Deviation |
| SRMR | Standardised Root Mean Square Residual |
| TLI | Tucker–Lewis Index |
References
- Bozzetti, M.; Guberti, M.; Cascio, A.L.; Privitera, D.; Genna, C.; Rodelli, S.; Turchini, L.; Amatucci, V.; Giordano, L.N.; Mora, V.; et al. Uncovering the Professional Landscape of Clinical Research Nursing: A Scoping Review with Data Mining Approach. Nurs. Rep. 2025, 15, 266. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Ramón, C.; Nievas-Soriano, B.J.; García-González, J.; Alarcón-Rodríguez, R.; Requena-Mullor, M.; Lozano-Paniagua, D. Motivation and Barriers to Research among Nursing Professionals in Southeast Spain. Healthcare 2022, 10, 675. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- American Nurses Association. Nursing: Scope and Standards of Practice, 4th ed.; American Nurses Association: Silver Spring, MD, USA, 2021. [Google Scholar]
- Chen, Q.; Sun, M.; Tang, S.; Castro, A.R. Research capacity in nursing: A concept analysis based on a scoping review. BMJ Open 2019, 9, e032356. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Parse, R.R. The 25-Year Evolution of Nursing Science Quarterly: Keeping the Dream Alive (Reprinted with permission). Nurs. Sci. Q. 2022, 35, 7–8. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Stolley, J.M.; Buckwalter, K.C.; Garand, L. The Evolution of Nursing Research. J. Neuromusculoskel. Syst. 2000, 8, 10–15. [Google Scholar]
- Brunt, B.A.; Morris, M.M. Nursing Professional Development Evidence-Based Practice. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2024. Available online: http://www.ncbi.nlm.nih.gov/books/NBK589676/ (accessed on 23 October 2024).
- Gros Navés, S.; Canet-Vélez, O.; Contreras-Higuera, W.; Garcia-Expósito, J.; Torralbas-Ortega, J.; Roca, J. Translation, Adaptation, and Psychometric Validation of the Spanish Version of the Attitudes towards Research and Development within Nursing Questionnaire. Int. J. Environ. Res. Public Health 2022, 19, 4623. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Rojaye, J.O.; Netangaheni, R.T. Participation of nurses in research development. Health SA Gesondheid 2023, 28, 2360. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Napolitano, D.; Amato, S.; Creta, E.; Profeta, F.; Foscarini, E.; Ribaudi, E.; Leonetti, A.; Fanali, C.; Ianiro, G.; Gasbarrini, A.; et al. The roles and professional competencies of clinical study coordinators and data managers in clinical trials: A systematic review. Clin. Trials 2026, 23, 189–197. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Hagen, N.A.; Howlett, J.; Sharma, N.C.; Biondo, P.; Holroyd-Leduc, J.; Fassbender, K.; Simon, J. Advance care planning: Identifying system-specific barriers and facilitators. Curr. Oncol. 2015, 22, 237–245. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Napolitano, D.; Settanni, C.R.; Parisio, L.; Orgiana, N.; Poscia, A.; Schiavoni, E.; Turchini, L.; Cascio, A.L.; Germini, F.; Sblendorio, E.; et al. Transition from intravenous to subcutaneous biological therapies in inflammatory bowel disease: An online survey of patients. Indian J. Gastroenterol. 2024, 43, 215–225. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Scala, E.; Price, C.; Day, J. An Integrative Review of Engaging Clinical Nurses in Nursing Research. J. Nurs. Scholarsh. 2016, 48, 423–430. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Smith, S.; Johnson, G. A systematic review of the barriers, enablers and strategies to embedding translational research within the public hospital system focusing on nursing and allied health professions. PLoS ONE 2023, 18, e0281819. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Bozzetti, M.; Cascio, A.L.; Napolitano, D.; Orgiana, N.; Mora, V.; Fiorini, S.; Petrucci, G.; Resente, F.; Baroni, I.; Caruso, R.; et al. Measuring What Matters in Trial Operations: Development and Validation of the Clinical Trial Site Performance Measure. J. Clin. Med. 2025, 14, 6839. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Bressan, V.; Bagnasco, A.; Bianchi, M.; Rossi, S.; Moschetti, F.; Barisone, M.; Pellegrini, R.; Aleo, G.; Timmins, F.; Sasso, L. Barriers to research awareness among nurses in Italy. J. Nurs. Manag. 2017, 25, 243–245. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Scarsini, S.; Narduzzi, B.; Cadorin, L.; Palese, A. Perceived Barriers and Enablers of Nursing Research in the Italian Context: Findings from a Systematic Review. Slov. J. Public Health 2022, 61, 181–190. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Napolitano, D.; Lo Cascio, A.; Bozzetti, M.; Guberti, M. Implementing research, improving practice: Synergizing the clinical research nurse and the nurse researcher. Minerva Gastroenterol. 2025, 71, 295–296. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Bozzetti, M.; Cascio, A.L.; Napolitano, D.; Curcio, F.; Amato, S.; Guardione, R.; Caruso, R.; Notarnicola, I.; Gonzalez, C.I.A.; Reato, F.; et al. Italian EBP Implementation Scales: A Psychometric Validation Study. Worldviews Evid.-Based Nurs. 2026, 23, e70114. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Bozzetti, M.; Soncini, S.; Bassi, M.C.; Guberti, M. Assessment of Nursing Workload and Complexity Associated with Oncology Clinical Trials: A Scoping Review. Semin. Oncol. Nurs. 2024, 40, 151711. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Kerr, D.; Alice, A.; Giddings, W.; Wynne, R. Nurses’ Opinions About Clinical Nursing Research: A Cross-Sectional Study. J. Adv. Nurs. 2025, 82, 6005–6017. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Sannino, P.; Maiandi, S.; Moretti, S.; Rampini, S.; Bonino, M.; Marchisio, P. Bridging the gap: Barriers and opportunities in pediatric nursing research in Italy. J. Pediatr. Nurs. 2025, 85, 207–212. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- von Elm, E.; Altman, D.G.; Egger, M.; Pocock, S.J.; Gotzsche, P.C.; Vandenbroucke, J.P. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. BMJ 2007, 335, 806–808. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Hagan, J.; Walden, M. Development and Evaluation of the Barriers to Nurses’ Participation in Research Questionnaire at a Large Academic Pediatric Hospital. Clin. Nurs. Res. 2017, 26, 157–175. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Beaton, D.E.; Bombardier, C.; Guillemin, F.; Ferraz, M.B. Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 2000, 25, 3186–3191. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Ayre, C.; Scally, A.J. Critical values for Lawshe’s content validity ratio: Revisiting the original methods of calculation. Meas. Eval. Couns. Dev. 2014, 47, 79–86. [Google Scholar] [CrossRef] [Scilit]
- Brown, C.E.; Ecoff, L.; Kim, S.C.; Wickline, M.A.; Rose, B.; Klimpel, K.; Glaser, D. Multi-institutional study of barriers to research utilisation and evidence-based practice among hospital nurses. J. Clin. Nurs. 2010, 19, 1944–1951. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Watkins, M.W. Exploratory factor analysis: A guide to best practice. J. Black Psychol. 2018, 44, 219–246. [Google Scholar] [CrossRef] [Scilit]
- Prokofieva, M.; Zarate, D.; Parker, A.; Palikara, O.; Stavropoulos, V. Exploratory structural equation modeling: A streamlined step by step approach using the R Project software. BMC Psychiatry 2023, 23, 546. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- van Zyl, L.E.; Klooster, P.M.T. Exploratory Structural Equation Modeling: Practical Guidelines and Tutorial With a Convenient Online Tool for Mplus. Front. Psychiatry 2022, 12, 795672. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Marsh, H.W.; Morin, A.J.S.; Parker, P.D.; Kaur, G. Exploratory structural equation modeling: An integration of the best features of exploratory and confirmatory factor analysis. Annu. Rev. Clin. Psychol. 2014, 10, 85–110. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Arnold, K.F.; Davies, V.; de Kamps, M.; Tennant, P.W.G.; Mbotwa, J.; Gilthorpe, M.S. Reflection on modern methods: Generalized linear models for prognosis and intervention—Theory, practice and implications for machine learning. Int. J. Epidemiol. 2020, 49, 2074–2082. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Barends, E.; Villanueva, J.; Rousseau, D.M.; Briner, R.B.; Jepsen, D.M.; Houghton, E.; Have, S.T. Managerial attitudes and perceived barriers regarding evidence-based practice: An international survey. PLoS ONE 2017, 12, e0184594. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Catania, G.; Poirè, I.; Bernardi, M.; Bono, L.; Cardinale, F.; Dozin, B. The role of the clinical trial nurse in Italy. Eur. J. Oncol. Nurs. 2012, 16, 87–93. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Kajermo, K.N.; Boström, A.M.; Thompson, D.S.; Hutchinson, A.M.; Estabrooks, C.A.; Wallin, L. The BARRIERS scale—the barriers to research utilization scale: A systematic review. Implement. Sci. 2010, 5, 32. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- van Oostveen, C.J.; Goedhart, N.S.; Francke, A.L.; Vermeulen, H. Combining clinical practice and academic work in nursing: A qualitative study about perceived importance, facilitators and barriers regarding clinical academic careers for nurses in university hospitals. J. Clin. Nurs. 2017, 26, 4973–4984. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Loke, J.C.F.; Laurenson, M.C.; Lee, K.W. Embracing a culture in conducting research requires more than nurses’ enthusiasm. Nurse Educ. Today 2014, 34, 132–137. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Berthelsen, C.B.; Hølge-Hazelton, B. Orthopaedic nurses’ attitudes towards clinical nursing research—A cross-sectional survey. Int. J. Orthop. Trauma Nurs. 2015, 19, 74–84. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Bozzetti, M.; Apadula, L.; Magon, A.; Conte, G.; Napolitano, D.; Villa, G.; Guberti, M.; Caruso, R. Development and Exploratory Validation of the Clinical Research Nursing Competencies-Self-Efficacy Scale. Healthcare 2026, 14, 551. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Munyisia, E.; Yu, P.; Hailey, D. Does the introduction of an electronic nursing documentation system in a nursing home reduce time on documentation for the nursing staff? Int. J. Med. Inform. 2011, 80, 782–792. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Cortese, C.G. Job satisfaction of Italian nurses: An exploratory study. J. Nurs. Manag. 2007, 15, 303–312. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Morrison, L.; Johnston, B.; Cooper, M. Mixed methods systematic review: Factors influencing research activity among nurses in clinical practice. J. Clin. Nurs. 2022, 31, 2450–2464. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Carter, E.J.; Rivera, R.R.; Gallagher, K.A.; Cato, K.D. Targeted Interventions to Advance a Culture of Inquiry at a Large, Multicampus Hospital Among Nurses. J. Nurs. Adm. 2018, 48, 18–24. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Association of Women’s Health, Obstetric and Neonatal Nurses. Standards for Professional Nursing Practice in the Care of Women, Newborns, and People Across the Life Span, Ninth Edition. J. Obstet. Gynecol. Neonatal Nurs. 2024, 53, e4–e40. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Farquharson, B. What helps or hinders nurses to lead funded research projects? A survey of UK nurse lead-investigators. J. Adv. Nurs. 2024, 80, 1464–1472. [Google Scholar] [CrossRef] [Scilit] [PubMed]
| Variables | n (%) |
|---|---|
| Gender | |
| Female | 163 (82.74%) |
| Male | 33 (16.75%) |
| Do you have direct experience in research? | |
| No | 128 (65.33%) |
| Yes | 68 (34.67%) |
| Have you ever conducted a nursing study? | |
| No | 94 (47.96%) |
| Yes | 102 (52.04%) |
| Did the course of study you completed include a session dedicated to clinical research? | |
| No | 76 (38.78%) |
| Yes | 120 (61.22%) |
| Do you think that your university education provided you with the appropriate tools to conduct research? | |
| No | 115 (58.67%) |
| Yes | 81 (41.33%) |
| Education | |
| Bachelors degree | 66 (34.51%) |
| First-level master’s degree | 82 (41.62%) |
| Second-level master’s degree | 41 (20.81%) |
| Advanced course | 1 (0.51%) |
| PhD | 4 (2.03%) |
| Setting | |
| Hospital | 64 (32.49%) |
| Scientific Institute for Research, Hospitalisation and Healthcare | 61 (30.96%) |
| University Hospital | 47 (23.86%) |
| Primary Care | 16 (8.12%) |
| Items | Research Resources (F1) λ (SE) | Personal Relevance of Research (F2) λ (SE) |
|---|---|---|
| Lack of availability of experienced nursing research mentors (Item 3) | 0.616 (0.088) | 0.120 (0.045) |
| Lack of institutional nursing research infrastructure (Item 4) | 0.814 (0.069) | 0.093 (0.040) |
| Lack of incentive/reward for nurses to do research (Item 5) | 0.544 (0.064) | 0.111 (0.042) |
| Lack of financial or other resources to facilitate nursing research (Item 11) | 0.512 (0.075) | 0.129 (0.048) |
| Lack of accessibility to a Nursing Research Council (Item 12) | 0.759 (0.105) | 0.144 (0.050) |
| Lack of leadership support (Item 13) | 0.564 (0.100) | 0.125 (0.047) |
| Lack of research training opportunities (Item 15) | 0.712 (0.094) | 0.135 (0.049) |
| Lack of research knowledge or skills (Item 2 merged 6) | 0.312 (0.043) | 0.951 (0.083) |
| My training and educational background do not qualify me to conduct research (Item 8) | 0.120 (0.045) | 0.888 (0.074) |
| I do not have ideas for research project topics (Item 10) | 0.115 (0.044) | 0.628 (0.083) |
| Research is not very interesting or valuable to me (Item 14) | 0.095 (0.041) | 0.563 (0.094) |
| Items | Mean | SD |
|---|---|---|
| Research resources (F1) | 3.89 | 0.62 |
| Lack of availability of experienced nursing research mentors (Item 3) | 3.81 | 1.00 |
| Lack of institutional nursing research infrastructure (Item 4) | 3.85 | 1.02 |
| Lack of incentive/reward for nurses to do research (Item 5) | 4.36 | 0.78 |
| Lack of financial or other resources to facilitate nursing research (Item 11) | 4.06 | 0.81 |
| Lack of accessibility to a Nursing Research Council (Item 12) | 3.88 | 0.93 |
| Lack of leadership support (Item 13) | 3.94 | 0.95 |
| Lack of research training opportunities (Item 15) | 3.35 | 1.06 |
| Personal relevance of research (F2) | 2.24 | 0.72 |
| Lack of research knowledge or skills (Item 2 merged 6) | 2.90 | 0.95 |
| My training and educational background do not qualify me to conduct research (Item 8) | 2.27 | 1.09 |
| I do not have ideas for research project topics (Item 10) | 2.21 | 1.02 |
| Research is not very interesting or valuable to me (Item 14) | 1.58 | 0.85 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Bozzetti, M.; Lo Cascio, A.; Colalelli, M.; Martella, P.; Pendoni, R.; Piredda, M.; Hagan, J.; Guberti, M.; Napolitano, D. Cross-Cultural Adaptation and Psychometric Testing of the Italian Barriers to Nursing Research Participation (I-BNPRQ). Healthcare 2026, 14, 1793. https://doi.org/10.3390/healthcare14121793
Bozzetti M, Lo Cascio A, Colalelli M, Martella P, Pendoni R, Piredda M, Hagan J, Guberti M, Napolitano D. Cross-Cultural Adaptation and Psychometric Testing of the Italian Barriers to Nursing Research Participation (I-BNPRQ). Healthcare. 2026; 14(12):1793. https://doi.org/10.3390/healthcare14121793
Chicago/Turabian StyleBozzetti, Mattia, Alessio Lo Cascio, Michela Colalelli, Piergiorgio Martella, Roberta Pendoni, Michela Piredda, Joseph Hagan, Monica Guberti, and Daniele Napolitano. 2026. "Cross-Cultural Adaptation and Psychometric Testing of the Italian Barriers to Nursing Research Participation (I-BNPRQ)" Healthcare 14, no. 12: 1793. https://doi.org/10.3390/healthcare14121793
APA StyleBozzetti, M., Lo Cascio, A., Colalelli, M., Martella, P., Pendoni, R., Piredda, M., Hagan, J., Guberti, M., & Napolitano, D. (2026). Cross-Cultural Adaptation and Psychometric Testing of the Italian Barriers to Nursing Research Participation (I-BNPRQ). Healthcare, 14(12), 1793. https://doi.org/10.3390/healthcare14121793

