Next Article in Journal
Healing Bodies, Healing Communities: A Community-Based Qualitative Study of Adult Survivors of Childhood Sexual Trauma in South Africa
Previous Article in Journal
Assessment of Dental Fear and Anxiety Tools for Children: A Review
Previous Article in Special Issue
Fixation Methods in Primary Hip Arthroplasty: A Nationwide, Registry-Based Observational Study in Romania (2001–2024)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Healthcare
Volume 13
Issue 20
10.3390/healthcare13202599
healthcare-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Healthcare Management in Cardio-Oncology, Clinical Strategies and Future Perspectives: A Narrative Review

by
Vincenzo Quagliariello
1,*,
Massimiliano Berretta
2,
Fabrizio Maurea
3,
Matteo Barbato
1,
Andrea Paccone
1,
Martina Iovine
1,
Alfredo Mauriello
1,
Celeste Fonderico
1,
Domenico Gabrielli
4,
Andrea Camerini
5,
Carmine Riccio
6,
Marino Scherillo
7,
Stefano Oliva
8,
Maria Laura Canale
9 and
Nicola Maurea
1
1
Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale of Naples, 80131 Naples, Italy
2
Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
3
Department of Medical Oncology, University Federico II of Naples, 80138 Naples, Italy
4
UOC Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliera San Camillo Forlanini, Roma—Fondazione per il Tuo Cuore—Heart Care Foundation, 50121 Firenze, Italy
5
Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord-Ovest, 55041 Lido di Camaiore, Italy
6
UOSD Follow-up del Paziente Post-Acuto, Dipartimento Cardio-Vascolare, AORN Sant’Anna e San Sebastiano, 81100 Caserta, Italy
7
Cardiologia Interventistica e UTIC, A.O. San Pio, Presidio Ospedaliero Gaetano Rummo, 82100 Benevento, Italy
8
UOSD Cardiologia di Interesse Oncologico-IRCCS-Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
9
Cardiology Department, Versilia Hospital, Azienda USL Toscana Nord-Ovest, 55041 Lido di Camaiore, Italy
*
Author to whom correspondence should be addressed.
Healthcare 2025, 13(20), 2599; https://doi.org/10.3390/healthcare13202599
Submission received: 15 September 2025 / Revised: 13 October 2025 / Accepted: 15 October 2025 / Published: 15 October 2025
(This article belongs to the Special Issue Advances in Public Health and Healthcare Management for Chronic Care)
Versions Notes

Abstract

The growing overlap between cardiovascular disease and cancer has made cardio-oncology a key subspecialty in modern oncology care. Improved cancer survival has increased the burden of therapy-related cardiovascular complications, including heart failure, arrhythmias, ischemic events, and vascular toxicity, driven by oxidative stress, endothelial dysfunction, immune-mediated injury, and metabolic vulnerability. Effective management requires a continuum-of-care approach, integrating baseline risk assessment, biomarker- and imaging-guided surveillance, and timely cardioprotective therapy without compromising cancer treatment. Key strategies include validated risk scores (HFA/ICOS, Mayo), early detection of subclinical dysfunction via troponin, natriuretic peptides, and strain imaging, and proactive cardioprotective agents such as ACE inhibitors, beta-blockers, SGLT2 inhibitors, and statins in high-risk patients. This narrative review summarizes risk-stratification models, structured care pathways, and multidisciplinary hub-and-spoke networks linking specialized centers with community oncology services. It emphasizes modifiable cardiometabolic factors, obesity, insulin resistance, NAFLD, sarcopenia, and chronic inflammation, which heighten cardiotoxicity risk and should guide precision prevention and survivorship care. We also address emerging challenges, including the integration of digital health, tele-monitoring, and AI-based decision support, and the shift toward value-based reimbursement models, highlighting persistent barriers such as data privacy, infrastructure gaps, and inequitable access to specialized care.
Keywords: cancer; cardio-oncology; management; healthcare; primary prevention; secondary prevention; diagnosis cancer; cardio-oncology; management; healthcare; primary prevention; secondary prevention; diagnosis

Share and Cite

MDPI and ACS Style

Quagliariello, V.; Berretta, M.; Maurea, F.; Barbato, M.; Paccone, A.; Iovine, M.; Mauriello, A.; Fonderico, C.; Gabrielli, D.; Camerini, A.; et al. Healthcare Management in Cardio-Oncology, Clinical Strategies and Future Perspectives: A Narrative Review. Healthcare 2025, 13, 2599. https://doi.org/10.3390/healthcare13202599

AMA Style

Quagliariello V, Berretta M, Maurea F, Barbato M, Paccone A, Iovine M, Mauriello A, Fonderico C, Gabrielli D, Camerini A, et al. Healthcare Management in Cardio-Oncology, Clinical Strategies and Future Perspectives: A Narrative Review. Healthcare. 2025; 13(20):2599. https://doi.org/10.3390/healthcare13202599

Chicago/Turabian Style

Quagliariello, Vincenzo, Massimiliano Berretta, Fabrizio Maurea, Matteo Barbato, Andrea Paccone, Martina Iovine, Alfredo Mauriello, Celeste Fonderico, Domenico Gabrielli, Andrea Camerini, and et al. 2025. "Healthcare Management in Cardio-Oncology, Clinical Strategies and Future Perspectives: A Narrative Review" Healthcare 13, no. 20: 2599. https://doi.org/10.3390/healthcare13202599

APA Style

Quagliariello, V., Berretta, M., Maurea, F., Barbato, M., Paccone, A., Iovine, M., Mauriello, A., Fonderico, C., Gabrielli, D., Camerini, A., Riccio, C., Scherillo, M., Oliva, S., Canale, M. L., & Maurea, N. (2025). Healthcare Management in Cardio-Oncology, Clinical Strategies and Future Perspectives: A Narrative Review. Healthcare, 13(20), 2599. https://doi.org/10.3390/healthcare13202599

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop