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Article

The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease

by
Iulia-Diana Stanca
1,†,
Oana Criciotoiu
1,*,
Simona-Daniela Neamtu
2,
Ramona-Constantina Vasile
3,
Nicoleta-Madalina Berceanu-Bora
4,
Teodora-Nicoleta Minca
4,
Ionica Pirici
5,*,
Gabriela-Camelia Rosu
6,† and
Simona Bondari
7
1
Department of Neurology, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
2
Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
3
Department of Epidemiology, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
4
Department of Neurology, Clinical Hospital of Neuropsychiatry Craiova, Calea Bucuresti 99, 200473 Craiova, Romania
5
Department of Anatomy, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
6
Department of Research Methodology, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
7
Department of Radiology, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Healthcare 2022, 10(12), 2578; https://doi.org/10.3390/healthcare10122578
Submission received: 17 November 2022 / Revised: 14 December 2022 / Accepted: 16 December 2022 / Published: 19 December 2022
Review Reports Versions Notes

Abstract

Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflammation could also contribute to the degeneration of the nigrostriatal pathway. Here, we aimed to establish the feasibility of basic inflammatory biomarkers as prognostic factors in PD. The study was based on retrospective analyses of blood samples taken from patients diagnosed with PD, as well as from healthy subjects. Complete medical records, total leukocyte count with subpopulations, and erythrocyte sedimentation rate (ESR) were analyzed. We calculated the serum neutrophils-to-lymphocytes ratio (NLR) and platelet-to lymphocytes ratio (PLR), and also compared the laboratory data between the PD group and the control group. Only PLR and NLR showed statistically significant differences (p < 0.001 and 0.04, respectively). In our study, ESR did not show statistically significant correlations with motor score or with disability. In our research, ESR was correlated with the disease duration (p = 0.04), and PLR showed a significant correlation with disease stage (p = 0.027) and disease duration (p = 0.001), but not with motor state. These biomarkers could prove to be effective tools for a primary evaluation of inflammation in PD, but further tests are required to properly investigate the neuroinflammatory status of these patients.
Keywords: Parkinson’s disease; neuroinflammation; peripheral immune system; neutrophile-to-lymphocyte ratio Parkinson’s disease; neuroinflammation; peripheral immune system; neutrophile-to-lymphocyte ratio

Share and Cite

MDPI and ACS Style

Stanca, I.-D.; Criciotoiu, O.; Neamtu, S.-D.; Vasile, R.-C.; Berceanu-Bora, N.-M.; Minca, T.-N.; Pirici, I.; Rosu, G.-C.; Bondari, S. The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease. Healthcare 2022, 10, 2578. https://doi.org/10.3390/healthcare10122578

AMA Style

Stanca I-D, Criciotoiu O, Neamtu S-D, Vasile R-C, Berceanu-Bora N-M, Minca T-N, Pirici I, Rosu G-C, Bondari S. The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease. Healthcare. 2022; 10(12):2578. https://doi.org/10.3390/healthcare10122578

Chicago/Turabian Style

Stanca, Iulia-Diana, Oana Criciotoiu, Simona-Daniela Neamtu, Ramona-Constantina Vasile, Nicoleta-Madalina Berceanu-Bora, Teodora-Nicoleta Minca, Ionica Pirici, Gabriela-Camelia Rosu, and Simona Bondari. 2022. "The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease" Healthcare 10, no. 12: 2578. https://doi.org/10.3390/healthcare10122578

APA Style

Stanca, I.-D., Criciotoiu, O., Neamtu, S.-D., Vasile, R.-C., Berceanu-Bora, N.-M., Minca, T.-N., Pirici, I., Rosu, G.-C., & Bondari, S. (2022). The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease. Healthcare, 10(12), 2578. https://doi.org/10.3390/healthcare10122578

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