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Review

Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Academic Editor: Jens R. Coorssen
Proteomes 2021, 9(1), 15; https://doi.org/10.3390/proteomes9010015
Received: 25 January 2021 / Revised: 18 March 2021 / Accepted: 20 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Feature Review Papers in Proteomes)
Proteomics researchers today face an interesting challenge: how to choose among the dozens of data processing and analysis pipelines available for converting tandem mass spectrometry files to protein identifications. Due to the dominance of Orbitrap technology in proteomics in recent history, many researchers have defaulted to the vendor software Proteome Discoverer. Over the fourteen years since the initial release of the software, it has evolved in parallel with the increasingly complex demands faced by proteomics researchers. Today, Proteome Discoverer exists in two distinct forms with both powerful commercial versions and fully functional free versions in use in many labs today. Throughout the 11 main versions released to date, a central theme of the software has always been the ability to easily view and verify the spectra from which identifications are made. This ability is, even today, a key differentiator from other data analysis solutions. In this review I will attempt to summarize the history and evolution of Proteome Discoverer from its first launch to the versions in use today. View Full-Text
Keywords: proteomics; protein informatics; glycoproteomics; mass spectrometry proteomics; protein informatics; glycoproteomics; mass spectrometry
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MDPI and ACS Style

Orsburn, B.C. Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics. Proteomes 2021, 9, 15. https://doi.org/10.3390/proteomes9010015

AMA Style

Orsburn BC. Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics. Proteomes. 2021; 9(1):15. https://doi.org/10.3390/proteomes9010015

Chicago/Turabian Style

Orsburn, Benjamin C. 2021. "Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics" Proteomes 9, no. 1: 15. https://doi.org/10.3390/proteomes9010015

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