Next Article in Journal
Rapid Liquid AP-MALDI MS Profiling of Lipids and Proteins from Goat and Sheep Milk for Speciation and Colostrum Analysis
Next Article in Special Issue
Short-Chain Fatty Acids Modulate Metabolic Pathways and Membrane Lipids in Prevotella bryantii B14
Previous Article in Journal
New Insights into Inflammatory Bowel Diseases from Proteomic and Lipidomic Studies
Previous Article in Special Issue
Proteomics of Brucella
Open AccessFeature PaperArticle

Cellular and Extracellular Proteome of the Animal Pathogen Corynebacterium silvaticum, a Close Relative of Zoonotic Corynebacterium ulcerans and Corynebacterium pseudotuberculosis

1
Microbiology Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany
2
Biochemistry Division, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Proteomes 2020, 8(3), 19; https://doi.org/10.3390/proteomes8030019
Received: 20 July 2020 / Revised: 3 August 2020 / Accepted: 10 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Microbial Proteomics II)
Corynebacterium silvaticum is a newly described animal pathogen, closely related to the emerging human pathogen Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, a major pathogen of small ruminants. In this study, proteins of a whole cell and a shaving fraction and the exoproteome of C. silvaticum strain W25 were analyzed as a first proteome study of this species. In total, 1305 proteins were identified out of 2013 proteins encoded by the W25 genome sequence and number of putative virulence factors were detected already under standard growth conditions including phospholipase D and sialidase. An up to now uncharacterized trypsin-like protease is by far the most secreted protein in this species, indicating a putative role in pathogenicity. Furthermore, the proteome analyses carried out in this study support the recently published taxonomical delineation of C. silvaticum from the closely related zoonotic Corynebacterium species. View Full-Text
Keywords: exoproteome; LC-MS/MS; mass spectrometry; necrotizing lymphadenitis; secretome; trypsin-like serine protease; zoonosis exoproteome; LC-MS/MS; mass spectrometry; necrotizing lymphadenitis; secretome; trypsin-like serine protease; zoonosis
Show Figures

Graphical abstract

MDPI and ACS Style

Möller, J.; Schorlemmer, S.; Hofmann, J.; Burkovski, A. Cellular and Extracellular Proteome of the Animal Pathogen Corynebacterium silvaticum, a Close Relative of Zoonotic Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Proteomes 2020, 8, 19.

AMA Style

Möller J, Schorlemmer S, Hofmann J, Burkovski A. Cellular and Extracellular Proteome of the Animal Pathogen Corynebacterium silvaticum, a Close Relative of Zoonotic Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Proteomes. 2020; 8(3):19.

Chicago/Turabian Style

Möller, Jens; Schorlemmer, Svenja; Hofmann, Jörg; Burkovski, Andreas. 2020. "Cellular and Extracellular Proteome of the Animal Pathogen Corynebacterium silvaticum, a Close Relative of Zoonotic Corynebacterium ulcerans and Corynebacterium pseudotuberculosis" Proteomes 8, no. 3: 19.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop