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Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity

by Joongkyu Park 1,2
1
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
2
Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proteomes 2018, 6(4), 40; https://doi.org/10.3390/proteomes6040040
Received: 11 September 2018 / Revised: 4 October 2018 / Accepted: 6 October 2018 / Published: 8 October 2018
(This article belongs to the Special Issue Neuroproteomics)
Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity. View Full-Text
Keywords: phosphorylation; AMPA receptor complex; transmembrane AMPA receptor regulatory protein; synaptic plasticity phosphorylation; AMPA receptor complex; transmembrane AMPA receptor regulatory protein; synaptic plasticity
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Park, J. Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity. Proteomes 2018, 6, 40.

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