Next Article in Journal
Detection of Functional Overreaching in Endurance Athletes Using Proteomics
Next Article in Special Issue
Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area
Previous Article in Journal / Special Issue
Regional Diversity in the Postsynaptic Proteome of the Mouse Brain
Open AccessFeature PaperReview

Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias

Massachusetts General Hospital Department of Neurology, Charlestown, MA 02129, USA
*
Author to whom correspondence should be addressed.
Proteomes 2018, 6(3), 32; https://doi.org/10.3390/proteomes6030032
Received: 20 July 2018 / Revised: 22 August 2018 / Accepted: 29 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Neuroproteomics)
Neurodegenerative dementias are highly complex disorders driven by vicious cycles of intersecting pathophysiologies. While most can be definitively diagnosed by the presence of disease-specific pathology in the brain at postmortem examination, clinical disease presentations often involve substantially overlapping cognitive, behavioral, and functional impairment profiles that hamper accurate diagnosis of the specific disease. As global demographics shift towards an aging population in developed countries, clinicians need more sensitive and specific diagnostic tools to appropriately diagnose, monitor, and treat neurodegenerative conditions. This review is intended as an overview of how modern proteomic techniques (liquid chromatography mass spectrometry (LC-MS/MS) and advanced capture-based technologies) may contribute to the discovery and establishment of better biofluid biomarkers for neurodegenerative disease, and the limitations of these techniques. The review highlights some of the more interesting technical innovations and common themes in the field but is not intended to be an exhaustive systematic review of studies to date. Finally, we discuss clear reporting principles that should be integrated into all studies going forward to ensure data is presented in sufficient detail to allow meaningful comparisons across studies. View Full-Text
Keywords: neurodegeneration; Alzheimer’s disease; cerebrospinal fluid; plasma; serum; proteomics; biomarkers; LC-MS/MS neurodegeneration; Alzheimer’s disease; cerebrospinal fluid; plasma; serum; proteomics; biomarkers; LC-MS/MS
Show Figures

Figure 1

MDPI and ACS Style

Carlyle, B.C.; Trombetta, B.A.; Arnold, S.E. Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias. Proteomes 2018, 6, 32.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop