Next Article in Journal
Let There Be Light!
Next Article in Special Issue
Phosphoproteome Discovery in Human Biological Fluids
Previous Article in Journal
Arabidopsis Regenerating Protoplast: A Powerful Model System for Combining the Proteomics of Cell Wall Proteins and the Visualization of Cell Wall Dynamics
Previous Article in Special Issue
A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples
Article Menu

Export Article

Open AccessReview

The Proteome of the Red Blood Cell: An Auspicious Source of New Insights into Membrane-Centered Regulation of Homeostasis

Department of Biochemistry (286), Radboud University Medical Center and Radboud Institute for Molecular Sciences, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands
Academic Editors: Edwin Lasonder and Jacek R. Wisniewski
Proteomes 2016, 4(4), 35;
Received: 16 September 2016 / Revised: 3 November 2016 / Accepted: 17 November 2016 / Published: 25 November 2016
(This article belongs to the Special Issue Clinical Proteomics)
PDF [191 KB, uploaded 25 November 2016]


During the past decade, the hand-in-hand development of biotechnology and bioinformatics has enabled a view of the function of the red blood cell that surpasses the supply of oxygen and removal of carbon dioxide. Comparative proteomic inventories have yielded new clues to the processes that regulate membrane–cytoskeleton interactions in health and disease, and to the ways by which red blood cells communicate with their environment. In addition, proteomic data have revealed the possibility that many, hitherto unsuspected, metabolic processes are active in the red blood cell cytoplasm. Recent metabolomic studies have confirmed and expanded this notion. Taken together, the presently available data point towards the red blood cell membrane as the hub at which all regulatory processes come together. Thus, alterations in the association of regulatory proteins with the cell membrane may be a sine qua non for the functional relevance of any postulated molecular mechanism. From this perspective, comparative proteomics centered on the red blood cell membrane constitute a powerful tool for the identification and elucidation of the physiologically and pathologically relevant pathways that regulate red blood cell homeostasis. Additionally, this perspective provides a focus for the interpretation of metabolomic studies, especially in the development of biomarkers in the blood. View Full-Text
Keywords: aging; biomarkers; metabolomics; membrane; proteomics; red blood cells aging; biomarkers; metabolomics; membrane; proteomics; red blood cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Bosman, G.J.C.G.M. The Proteome of the Red Blood Cell: An Auspicious Source of New Insights into Membrane-Centered Regulation of Homeostasis. Proteomes 2016, 4, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Proteomes EISSN 2227-7382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top