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Article

A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples

1
Department of Medicine, San Juan Bautista School of Medicine, Caguas 00727, Puerto Rico
2
Quantitative Proteomics Laboratory, Comprehensive Cancer Center of Puerto Rico, San Juan 00936, Puerto Rico
3
Department of Internal Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan 00936, Puerto Rico
*
Authors to whom correspondence should be addressed.
Proteomes 2016, 4(4), 31; https://doi.org/10.3390/proteomes4040031
Submission received: 28 June 2016 / Revised: 19 September 2016 / Accepted: 21 September 2016 / Published: 17 October 2016
(This article belongs to the Special Issue Clinical Proteomics)

Abstract

The proper handling of samples to be analyzed by mass spectrometry (MS) can guarantee excellent results and a greater depth of analysis when working in quantitative proteomics. This is critical when trying to assess non-traditional sources such as ear wax, saliva, vitreous humor, aqueous humor, tears, nipple aspirate fluid, breast milk/colostrum, cervical-vaginal fluid, nasal secretions, bronco-alveolar lavage fluid, and stools. We intend to provide the investigator with relevant aspects of quantitative proteomics and to recognize the most recent clinical research work conducted with atypical samples and analyzed by quantitative proteomics. Having as reference the most recent and different approaches used with non-traditional sources allows us to compare new strategies in the development of novel experimental models. On the other hand, these references help us to contribute significantly to the understanding of the proportions of proteins in different proteomes of clinical interest and may lead to potential advances in the emerging field of precision medicine.
Keywords: quantitative proteomics; MS/MS; clinical samples; precision medicine; screening quantitative proteomics; MS/MS; clinical samples; precision medicine; screening

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MDPI and ACS Style

Licier, R.; Miranda, E.; Serrano, H. A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples. Proteomes 2016, 4, 31. https://doi.org/10.3390/proteomes4040031

AMA Style

Licier R, Miranda E, Serrano H. A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples. Proteomes. 2016; 4(4):31. https://doi.org/10.3390/proteomes4040031

Chicago/Turabian Style

Licier, Rígel, Eric Miranda, and Horacio Serrano. 2016. "A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples" Proteomes 4, no. 4: 31. https://doi.org/10.3390/proteomes4040031

APA Style

Licier, R., Miranda, E., & Serrano, H. (2016). A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples. Proteomes, 4(4), 31. https://doi.org/10.3390/proteomes4040031

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