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Phosphoproteome Discovery in Human Biological Fluids

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Author to whom correspondence should be addressed.
Academic Editors: Edwin Lasonder and Jacek R. Wisniewski
Proteomes 2016, 4(4), 37;
Received: 9 June 2016 / Revised: 11 November 2016 / Accepted: 23 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Clinical Proteomics)
Phosphorylation plays a critical role in regulating protein function and thus influences a vast spectrum of cellular processes. With the advent of modern bioanalytical technologies, examination of protein phosphorylation on a global scale has become one of the major research areas. Phosphoproteins are found in biological fluids and interrogation of the phosphoproteome in biological fluids presents an exciting opportunity for discoveries that hold great potential for novel mechanistic insights into protein function in health and disease, and for translation to improved diagnostic and therapeutic approaches for the clinical setting. This review focuses on phosphoproteome discovery in selected human biological fluids: serum/plasma, urine, cerebrospinal fluid, saliva, and bronchoalveolar lavage fluid. Bioanalytical workflows pertinent to phosphoproteomics of biological fluids are discussed with emphasis on mass spectrometry-based approaches, and summaries of studies on phosphoproteome discovery in major fluids are presented. View Full-Text
Keywords: phosphoproteome; mass spectrometry; biological fluid; biomarker phosphoproteome; mass spectrometry; biological fluid; biomarker
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Giorgianni, F.; Beranova-Giorgianni, S. Phosphoproteome Discovery in Human Biological Fluids. Proteomes 2016, 4, 37.

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