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Open AccessArticle

Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor

1
Research Center for Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
2
Innovative Flex Course for Frontier Organic Material Systems (iFront), Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
3
Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
*
Author to whom correspondence should be addressed.
Technologies 2018, 6(3), 77; https://doi.org/10.3390/technologies6030077
Received: 19 July 2018 / Revised: 11 August 2018 / Accepted: 13 August 2018 / Published: 15 August 2018
(This article belongs to the Special Issue Smart Systems)
Sensor devices that can be fabricated on a flexible plastic film produced at a low cost using inkjet-printing technology are suitable for point-of-care applications. An organic field-effect transistor (OFET)-based biosensor can function as a potentiometric electrochemical sensor. To investigate the usefulness of an OFET-based biosensor, we demonstrated the detection of 1,5-anhydroglucitol (1,5-AG) and glucose, which are monosaccharides used as biomarkers of diabetes. An OFET-based biosensor combined with a Prussian blue (PB) electrode, modified with glucose oxidase (GOx) or pyranose oxidase (POx), was utilized for the detection of the monosaccharides. When the GOx- or POx-PB electrode was immersed in glucose solution at the determined concentration, shifts in the low-voltage direction of transfer characteristic curves of the OFET were observed to be dependent on the glucose concentrations in the range of 0–10 mM. For 1,5-AG, the curve shifts were observed only with the POx-PB electrode. Detection of glucose and 1,5-AG was achieved in a substrate-specific manner of the enzymes on the printed OFET-biosensor. Although further improvements are required in the detection concentration range, the plastic-filmOFET-biosensors will enable the measurement of not only diabetes biomarkers but also various other biomarkers. View Full-Text
Keywords: organic field-effect transistor (OFET); diabetes biomarker; 1,5-anhydroglucitol; glucose; pyranose oxidase; glucose oxidase organic field-effect transistor (OFET); diabetes biomarker; 1,5-anhydroglucitol; glucose; pyranose oxidase; glucose oxidase
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MDPI and ACS Style

Furusawa, H.; Ichimura, Y.; Nagamine, K.; Shiwaku, R.; Matsui, H.; Tokito, S. Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor. Technologies 2018, 6, 77.

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