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Open AccessReview

Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population

Discipline of Clinical Pharmacology, School of Medicine, University of Newcastle, Hunter Medical Research Institute Newcastle, Newcastle 2308, Australia
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Pharmacy 2020, 8(1), 16; https://doi.org/10.3390/pharmacy8010016
Received: 18 December 2019 / Revised: 31 January 2020 / Accepted: 2 February 2020 / Published: 5 February 2020
A number of barriers and challenges must be overcome in order to conduct the pharmacokinetic studies that are urgently needed to inform the selection and dosing of medication in neonates. However, overcoming these barriers can be difficult. This review outlines the common barriers researchers are confronted with, including issues with ethics approval and consent, study design for pharmacokinetic studies and the ability to measure the drug concentrations in the blood samples obtained. Strategies to overcome these challenges are also proposed. View Full-Text
Keywords: neonate; pharmacokinetics; translational research; ethics; biomedical; modeling; drug neonate; pharmacokinetics; translational research; ethics; biomedical; modeling; drug
MDPI and ACS Style

O’Hara, K.; Martin, J.H.; Schneider, J.J. Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population. Pharmacy 2020, 8, 16.

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