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Pharmacy 2018, 6(2), 30;

Benzodiazepines Withdrawal: Initial Outcomes and Long-Term Impact on Falls in a French Nursing Home

Maison Hospitalière de Baccarat, 54120 Baccarat, France
Service de Pharmacie Clinique, Etablissement Public de Santé Alsace Nord, 67173 Brumath, France
Clinique Psychiatrique, Service de Psychiatrie II, Hôpital Civil, CHU de Strasbourg, 67091 Strasbourg, France
Equipe de Liaison et de Soins en Addictologie, C.H. Saint Jean de Dieu, 69008 Lyon, France
Service Pharmacie, CHU de Strasbourg, Faculté de Pharmacie, EA7396, 67091 Strasbourg, France
Author to whom correspondence should be addressed.
Received: 24 February 2018 / Revised: 4 April 2018 / Accepted: 4 April 2018 / Published: 6 April 2018
(This article belongs to the Special Issue Deprescribing)
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Long-term use of benzodiazepines (BZDs) is known to induce tolerance and dependence, and increase the risk of falls-related injuries in older adults. We present a study carried out in a French nursing home that concerns the implementation of a BZD withdrawal program reassessed at one year. BZD deprescription was achieved by gradual cessation of doses. A secondary benefit of this program was assessed by comparing the number of falls among residents before and after withdrawal. The number of falls was recorded over a six-month period prior to the onset of withdrawal (T1) and then over a six-month period after reassessment at one year (T2). At the beginning, 31 (28.7%) of the patients were under BZD. Total deprescription was obtained for 11 patients. The number of falls per patient over the T1 period was not different between the two groups (future non-withdrawn and withdrawn patients in BZD): 2.1 ± 1.3 and 2.3 ± 0.6 falls per resident, respectively. Conversely, the number of falls per patient was significantly decreased in the population completely withdrawn in BZD between the T1 and T2 periods (2.3 ± 0.6 vs. 0.5 ± 0.2 falls, p = 0.01). The results show that BZD deprescription, through a gradual reduction of doses, is possible to achieve. View Full-Text
Keywords: older patients; benzodiazepine; withdrawal; fall; deprescription older patients; benzodiazepine; withdrawal; fall; deprescription

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Javelot, H.; Marquis, A.; Antoine-Bernard, E.; Grandidier, J.; Weiner, L.; Javelot, T.; Michel, B. Benzodiazepines Withdrawal: Initial Outcomes and Long-Term Impact on Falls in a French Nursing Home. Pharmacy 2018, 6, 30.

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