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Article

Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo

1
Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, Korea
2
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea
3
Nine B Company, Daejeon 34121, Korea
4
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan 31499, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Plants 2020, 9(9), 1114; https://doi.org/10.3390/plants9091114
Received: 3 August 2020 / Revised: 21 August 2020 / Accepted: 26 August 2020 / Published: 28 August 2020
(This article belongs to the Special Issue Plant Nutrition)
Osteoporosis is a porous bone disease caused by bone density loss, which increases the risk of fractures. Cornus officinalis (CO) and Achyranthes japonica (AJ) have been used as traditional herbal medicine for various disorders in East Asia. Although the anti-osteoporotic effects of single extract of CO and AJ have already been reported, the synergistic effect of a combined mixture has not been studied. In this study, we investigated the effects of a CO and AJ herbal mixture on osteoporosis in in vitro and in vivo models. The results demonstrate that treatment with the CO and AJ mixture significantly promoted osteoblast differentiation of MC3T3-E1 mouse preosteoblasts through the upregulation of osteoblastic differentiation-associated genes such as alkaline phosphatase (Alpl), runt-related transcription factor 2 (Runx2), and bone gamma-carboxyglutamic acid-containing protein (Bglap), while the mixture significantly inhibited differentiation of osteoclasts isolated from primary-cultured mouse monocytes. In addition, oral administration of CO and AJ mixture significantly prevented bone mineral density loss and trabecular bone structures in an ovariectomy-induced osteoporotic mouse model. These results suggest that the combination treatment of CO and AJ mixture might be a beneficial therapy for osteoporosis. View Full-Text
Keywords: osteoporosis; Cornus officinalis; Achyranthes japonica; ovariectomized (OVX) mice; herbal medicine osteoporosis; Cornus officinalis; Achyranthes japonica; ovariectomized (OVX) mice; herbal medicine
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MDPI and ACS Style

Park, E.; Lee, C.G.; Kim, J.; Lim, E.; Hwang, S.; Yun, S.H.; Yong, Y.; Jeong, H.; Kim, J.A.; Jin, H.-S.; Jeong, S.-Y. Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo. Plants 2020, 9, 1114. https://doi.org/10.3390/plants9091114

AMA Style

Park E, Lee CG, Kim J, Lim E, Hwang S, Yun SH, Yong Y, Jeong H, Kim JA, Jin H-S, Jeong S-Y. Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo. Plants. 2020; 9(9):1114. https://doi.org/10.3390/plants9091114

Chicago/Turabian Style

Park, Eunkuk, Chang G. Lee, Jeonghyun Kim, Eunguk Lim, Seokjin Hwang, Seung H. Yun, Yoonjoong Yong, Hyesoo Jeong, Ji A. Kim, Hyun-Seok Jin, and Seon-Yong Jeong. 2020. "Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo" Plants 9, no. 9: 1114. https://doi.org/10.3390/plants9091114

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